Results 21 to 30 of about 94,252 (292)

GPER-induced signaling is essential for the survival of breast cancer stem cells. [PDF]

, 2020
G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells.
Chan, Yu-Tzu, Chang, Wen-Wei, Chang, Wen-Ying, Chen, Yu-Ju, Lai, Alan C-Y, Lin, Ruey-Jen, Lin, Yu-Ju, Wang, Ya-Hui, Wang, Yi-Ting, Wu, Hsin-Yi, Wu, Jen-Chine, Yu, Alice L, Yu, Jyh-Cherng   +12 more
core   +2 more sources

Decreased Levels of G Protein-Coupled Estrogen Receptor in Bipolar Patients

Genel Tıp Dergisi, 2023
Objectives: There is increasing evidence in the literature that estrogen and its receptors play an important role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity and peak periods of the disease.
Nurinnisa Öztürk, Onur Hurşitoğlu, Ömer Faruk Uygur, Ergul Belge Kurutas   +3 more
doaj   +1 more source

G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish. [PDF]

PLoS Genetics, 2017
Estrogens act by binding to estrogen receptors alpha and beta (ERα, ERβ), ligand-dependent transcription factors that play crucial roles in sex differentiation, tumor growth and cardiovascular physiology.
Shannon N Romano, Hailey E Edwards, Jaclyn Paige Souder, Kevin J Ryan, Xiangqin Cui, Daniel A Gorelick   +5 more
doaj   +1 more source

Immunolocalization of G protein-coupled estrogen receptor in the rat epididymis [PDF]

Reproductive Biology and Endocrinology, 2015
Estrogen plays an important role in male reproduction, and males lacking estrogen signaling in the reproductive tissues are infertile. Estrogen signaling is mediated via two nuclear receptors, ERα and ERβ, but it was recently found that a G protein-coupled estrogen receptor (GPER) is present in the testis. It is believed that GPER is a membrane form of
Martinez-Traverso, Griselle B, Pearl, Christopher   +1 more
openaire   +2 more sources

The G-protein-coupled estrogen receptor GPER in health and disease [PDF]

Nature Reviews Endocrinology, 2011
Estrogens mediate profound effects throughout the body and regulate physiological and pathological processes in both women and men. The low prevalence of many diseases in premenopausal women is attributed to the presence of 17β-estradiol, the predominant and most potent endogenous estrogen.
Prossnitz, Eric R., Barton, Matthias
openaire   +3 more sources

Sex and the G Protein–Coupled Estrogen Receptor Impact Vascular Stiffness [PDF]

Hypertension, 2021
Because arterial stiffness increases following menopause, estrogen may be a protective factor. Our previous work indicates that the GPER (G protein–coupled estrogen receptor) mediates estrogen’s vascular actions. In the current study, we assessed arterial stiffening using pulse wave velocity (PWV), a clinically relevant measurement that independently ...
Benard O. Ogola, Gabrielle L. Clark, Caleb M. Abshire, Nicholas R. Harris, Kaylee L. Gentry, Shreya S. Gunda, Isabella Kilanowski-Doroh, Tristen J. Wong, Bruna Visniauskas, Dylan J. Lawrence, Margaret A. Zimmerman, Carolyn L. Bayer, Leanne Groban, Kristin S. Miller, Sarah H. Lindsey   +14 more
openaire   +2 more sources

Estrogen, angiogenesis, immunity and cell metabolism: Solving the puzzle [PDF]

, 2018
Estrogen plays an important role in the regulation of cardiovascular physiology and the immune system by inducing direct effects on multiple cell types including immune and vascular cells. Sex steroid hormones are implicated in cardiovascular protection,
Bolego, Chiara, BOSCARO, CARLOTTA, Cignarella, Andrea, Tedesco, Serena, Trenti, Annalisa, Trevisi, Lucia   +5 more
core   +2 more sources

Chlorobisphenol A activated kisspeptin/GPR54-GnRH neuroendocrine signals through ERα and GPER pathway in neuronal GT1-7 cells

Ecotoxicology and Environmental Safety, 2022
Chlorobisphenol A (ClxBPA) is a kind of novel estrogenic compounds. The present study aims to investigate the effects of three ClxBPA compounds on the kisspeptin/G protein-coupled receptor 54 (GPR54, also named KissR1)-gonadotropin-releasing hormone ...
Bingli Lei, Lanbing Xu, Yaoyao Huang, Yun Liu, Mengjie Yu, Qianqian Tang   +5 more
doaj   +1 more source

GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo [PDF]

, 2015
We have previously demonstrated that estrogen receptor (ER) alpha (ESR1) increases proliferation of adrenocortical carcinoma (ACC) through both an estrogen-dependent and -independent (induced by IGF-II/IGF1R pathways) manner.
Amendola, Donatella, Avena, Paola, Campana, Carmela, Carpinelli, Giulia, Casaburi, Ivan, Cerquetti, Lidia, Chimento, Adele, De Luca, Arianna, Domanico, Francesco, Fallo, Francesco, Malivindi, Rocco, Martire, Emilia, Pezzi, Vincenzo, Rizza, Pietro, Sirianni, Rosa, Stigliano, Antonio, Zolea, Fabiana   +16 more
core   +2 more sources

Role of estrogen receptors in health and disease

Frontiers in Endocrinology, 2022
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans. Abnormal ER signaling may result in various disorders, including reproductive system-related disorders (endometriosis, and breast, ovarian, and prostate cancer), bone ...
Peng Chen, Bo Li, Ling Ou-Yang
doaj   +1 more source