Results 21 to 30 of about 46,511 (206)

Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]

Pharmaceutical Sciences Asia, 2022
Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai, Deepa Sugumar, Dhritiman Roy, Divakar Selvaraj   +3 more
doaj   +1 more source

Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway

Journal of Ginseng Research, 2019
Background: Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase–mediated pathway.
Quan-Gui Gao, Li-Ping Zhou, Vien Hoi-Yi Lee, Hoi-Yi Chan, Cornelia Wing-Yin Man, Man-Sau Wong   +5 more
doaj   +1 more source

Estrogen Actions in Triple-Negative Breast Cancer

Cells, 2020
Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC.
Oliver Treeck, Susanne Schüler-Toprak, Olaf Ortmann   +2 more
doaj   +1 more source

Bisphenol A attenuates the therapeutic effect of the selective G protein-coupled estrogen receptor agonist G-1 on allergic rhinitis inflammation in mice

Ecotoxicology and Environmental Safety, 2022
Background: Bisphenol A (BPA) is found in many plastics widely used in everyday life and affects the immune system. Previous studies found that the selective G protein coupled estrogen receptor (GPER) agonist G-1 can reduce the inflammation associated ...
Yunxiu Wang, Zhiwei Cao, He Zhao, Zhaowei Gu   +3 more
doaj   +1 more source

G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Mantle Cell Lymphoma Growth in Preclinical Models

Frontiers in Oncology, 2021
Mantle cell lymphoma (MCL) is an aggressive form of non-Hodgkin’s B-cell lymphoma with poor prognosis. Despite recent advances, resistance to therapy and relapse remain significant clinical problems.
Lixia Zhou, Lixia Zhou, Tenghua Yu, Fei Yang, Jingjing Han, Bin Zuo, Lulu Huang, Xia Bai, Xia Bai, Xia Bai, Xia Bai, Miao Jiang, Depei Wu, Depei Wu, Suning Chen, Suning Chen, Lijun Xia, Lijun Xia, Jia Ruan, Changgeng Ruan, Changgeng Ruan, Changgeng Ruan, Changgeng Ruan   +22 more
doaj   +1 more source

Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors

Journal of Immunology Research, 2016
The G-protein-coupled estrogen receptor-1 (GPER-1), also known as GPR30, is a novel estrogen receptor mediating estrogen receptor signaling in multiple cell types.
Hongyan Qian, Jingxiu Xuan, Yuan Liu, Guixiu Shi   +3 more
doaj   +1 more source

GPER was associated with hypertension in post-menopausal women

Open Medicine, 2018
To explore the relationship between G protein-coupled estrogen receptor (GPER) and hypertension in post-menopausal women.
Liu Shichao, Ding Tongbin, Liu Hang, Jian Liguo   +3 more
doaj   +1 more source

Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal AdenocarcinomaSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Female sex is associated with lower incidence and improved clinical outcomes for most cancer types including pancreatic ductal adenocarcinoma (PDAC). The mechanistic basis for this sex difference is unknown.
Christopher A. Natale, Jinyang Li, Jason R. Pitarresi, Robert J. Norgard, Tzvete Dentchev, Brian C. Capell, John T. Seykora, Ben Z. Stanger, Todd W. Ridky   +8 more
doaj   +1 more source

G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth

Obstetrics and Gynecology International, 2013
Endometrial carcinoma is the most common cancer of the female reproductive tract. GPER/GPR30 is a 7-transmembrane spanning G protein-coupled receptor that has been identified as the third estrogen receptor, in addition to ERα and ERβ.
Whitney K. Petrie, Megan K. Dennis, Chelin Hu, Donghai Dai, Jeffrey B. Arterburn, Harriet O. Smith, Helen J. Hathaway, Eric R. Prossnitz   +7 more
doaj   +1 more source

Does GPER Really Function as a G Protein-Coupled Estrogen Receptor in vivo?

Frontiers in Endocrinology, 2020
Estrogen can elicit pleiotropic cellular responses via a diversity of estrogen receptors (ERs)—mediated genomic and rapid non-genomic mechanisms. Unlike the genomic responses, where the classical nuclear ERα and ERβ act as transcriptional factors ...
Jing Luo, Jing Luo, Dongmin Liu
doaj   +1 more source