The role of dimerisation in the cellular trafficking of G-protein-coupled receptors [PDF]
, 2010 The concept that G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well established. Despite this, how dynamic such interactions are and if this may be modulated during receptor trafficking remain topics of debate ...
Milligan, Graeme
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Ecotoxicology and Environmental Safety, 2022 Chlorobisphenol A (ClxBPA) is a kind of novel estrogenic compounds. The present study aims to investigate the effects of three ClxBPA compounds on the kisspeptin/G protein-coupled receptor 54 (GPR54, also named KissR1)-gonadotropin-releasing hormone ...
Bingli Lei +5 more
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Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]
Pharmaceutical Sciences Asia, 2022 Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai +3 more
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Prediction of Structure, Function, and Spectroscopic Properties of G-Protein-Coupled Receptors: Methods and Applications [PDF]
, 2004 G-protein-coupled receptors are of great pharmaceutical interest, comprising the majority of targets for currently marketed drugs. The theme of my thesis is the development of the structure prediction method, MembStruk, for the superfamily of G-protein ...
Trabanino, Rene Jouvanni
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Estrogen receptor beta and G protein-coupled estrogen receptor 1 are involved in the acute estrogenic regulation of arginine-vasopressin immunoreactive levels in the supraoptic and paraventricular hypothalamic nuclei of female rats [PDF]
, 2019 The ovarian hormone 17β-estradiol is known to regulate the release, expression and immunoreactivity of arginine-vasopressin (AVP) in the supraoptic and paraventricular hypothalamic nuclei of rodents.
Collado, Paloma +8 more
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Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia
Experimental Hematology & Oncology, 2022 Activating G protein-coupled estrogen receptor 1 (GPER1) is an attractive therapeutic strategy for treating a variety of human diseases including cancer.
Eugenio Morelli +22 more
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Journal of Ginseng Research, 2019 Background: Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase–mediated pathway.
Quan-Gui Gao +5 more
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Regulators of G protein signalling proteins in the human myometrium [PDF]
, 2009 The contractile state of the human myometrium is controlled by extracellular signals that promote relaxation or contraction. Many of these signals function through G proteincoupled receptors at the cell surface, stimulating heterotrimeric G proteins and ...
Ladds, Graham +4 more
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Frontiers in Endocrinology, 2020 Cancer is a major public health issue and represents the second leading cause of death in women worldwide, as female reproductive-related neoplasms are the main cause of incidence and mortality.
Christian David Hernández-Silva +4 more
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On the hierarchical classification of G Protein-Coupled Receptors [PDF]
, 2007 Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
Matthew N. Davies +11 more
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