Results 11 to 20 of about 94,252 (292)
Evidence for G‐Protein–Coupled Estrogen Receptor as a Pronatriuretic Factor
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background The novel estrogen receptor, G‐protein–coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt‐induced complications, yet there is no ...
Eman Y. Gohar +11 more
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Targeting the G protein-coupled estrogen receptor (GPER) in obesity and diabetes
Endocrine and Metabolic Science, 2021 Obesity has become a global epidemic in the modern world with the numbers of obese individuals having risen at alarming rates in the last decades. Obesity represents a serious medical condition that can lead to multiple complications, such as diabetes ...
Geetanjali Sharma, Eric R. Prossnitz
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Recent advances of G protein‐coupled estrogen receptor 1 in the metabolism of bone
Kouqiang hemian waike zazhi, 2023 The G protein‐coupled estrogen receptor 1 (GPER1) is a membrane receptor for estrogen and it plays an important role in estrogen mediated bone metabolism by triggering downstream responses through rapid cellular pleiotropic effects and influencing the ...
FENG Yuan, WANG Zuolin
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GPR30: A G protein-coupled receptor for estrogen [PDF]
Molecular and Cellular Endocrinology, 2007 Estrogen is a critical steroid in human physiology exerting its effect both at the transcriptional level as well as at the level of rapid intracellular signaling through second messengers. Many of estrogen's transcriptional effects have long been known to be mediated through classical nuclear steroid receptors but recent studies also demonstrate the ...
Eric R, Prossnitz +2 more
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Estrogen Receptor Function: Impact on the Human Endometrium
Frontiers in Endocrinology, 2022 The physiological role of estrogen in the female endometrium is well established. On the basis of responses to steroid hormones (progesterone, androgen, and estrogen), the endometrium is considered to have proliferative and secretory phases. Estrogen can
Kun Yu +5 more
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G Protein-coupled Estrogen Receptor Protects from Atherosclerosis [PDF]
Scientific Reports, 2014 Coronary atherosclerosis and myocardial infarction in postmenopausal women have been linked to inflammation and reduced nitric oxide (NO) formation. Natural estrogen exerts protective effects on both processes, yet also displays uterotrophic activity.
Meyer Matthias R. +9 more
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Frontiers in Cell and Developmental Biology, 2020 Mechanical forces regulate cell functions through multiple pathways. G protein-coupled estrogen receptor (GPER) is a seven-transmembrane receptor that is ubiquitously expressed across tissues and mediates the acute cellular response to estrogens.
Dariusz Lachowski +7 more
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Immunolocalization of G Protein‐Coupled Estrogen Receptor in the Pig Epididymis [PDF]
The Anatomical Record, 2018 ABSTRACTThe presence of estrogen in the genital ducts of different mammalian species has been extensively studied and the estrogen influence on the functional activity of the male genital tract has been hypothesized. Conversely, very few data have been reported on pig excurrent ducts: the localization of classical estrogen receptors (ERα and ERβ) is ...
Malivindi R., Aquila S., Rago V.
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Expression and estrogen regulation of G protein-coupled estrogen receptor in human glioblastoma cells. [PDF]
Oncol Lett, 2022 Glioblastoma (GB) is the most frequent primary brain tumor with a very poor prognosis. Sex hormones are crucial players in the development of GBs. 17 β-estradiol (E2) signaling is involved through its corresponding intracellular receptors [estrogen receptor α (ERα) and β (ERβ)] in GB cell proliferation and progression.
Peña-Gutiérrez KM +3 more
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Frontiers in Endocrinology, 2020 In the hippocampus, estrogen regulates gene transcription linked to neuronal growth, neuroprotection, and the maintenance of memory function (1–3). The mechanism is likely to involve genomic regulation through classic estrogen receptor (ER) signaling ...
Ashok Kumar, Thomas C. Foster
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