Results 11 to 20 of about 46,511 (206)
Estrogen Receptor Function: Impact on the Human Endometrium
Frontiers in Endocrinology, 2022 The physiological role of estrogen in the female endometrium is well established. On the basis of responses to steroid hormones (progesterone, androgen, and estrogen), the endometrium is considered to have proliferative and secretory phases. Estrogen can
Kun Yu +5 more
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Frontiers in Endocrinology, 2020 The regulatory role of estrogens and nuclear estrogen receptors, i. e., estrogen receptor α and β has been reported in gastrointestinal diseases. However, the contribution of G protein-coupled estrogen receptor, the membrane-bound estrogen receptor, is ...
Damian Jacenik, Wanda M. Krajewska
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Frontiers in Cell and Developmental Biology, 2020 Mechanical forces regulate cell functions through multiple pathways. G protein-coupled estrogen receptor (GPER) is a seven-transmembrane receptor that is ubiquitously expressed across tissues and mediates the acute cellular response to estrogens.
Dariusz Lachowski +7 more
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Frontiers in Endocrinology, 2020 In the hippocampus, estrogen regulates gene transcription linked to neuronal growth, neuroprotection, and the maintenance of memory function (1–3). The mechanism is likely to involve genomic regulation through classic estrogen receptor (ER) signaling ...
Ashok Kumar, Thomas C. Foster
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Decreased Levels of G Protein-Coupled Estrogen Receptor in Bipolar Patients
Genel Tıp Dergisi, 2023 Objectives: There is increasing evidence in the literature that estrogen and its receptors play an important role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity and peak periods of the disease.
Nurinnisa Öztürk +3 more
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Evidence for G‐Protein–Coupled Estrogen Receptor as a Pronatriuretic Factor
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background The novel estrogen receptor, G‐protein–coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt‐induced complications, yet there is no ...
Eman Y. Gohar +11 more
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G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish. [PDF]
PLoS Genetics, 2017 Estrogens act by binding to estrogen receptors alpha and beta (ERα, ERβ), ligand-dependent transcription factors that play crucial roles in sex differentiation, tumor growth and cardiovascular physiology.
Shannon N Romano +5 more
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Targeting the G protein-coupled estrogen receptor (GPER) in obesity and diabetes
Endocrine and Metabolic Science, 2021 Obesity has become a global epidemic in the modern world with the numbers of obese individuals having risen at alarming rates in the last decades. Obesity represents a serious medical condition that can lead to multiple complications, such as diabetes ...
Geetanjali Sharma, Eric R. Prossnitz
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Role of estrogen receptors in health and disease
Frontiers in Endocrinology, 2022 Estrogen receptors (ERs) regulate multiple complex physiological processes in humans. Abnormal ER signaling may result in various disorders, including reproductive system-related disorders (endometriosis, and breast, ovarian, and prostate cancer), bone ...
Peng Chen, Bo Li, Ling Ou-Yang
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Ecotoxicology and Environmental Safety, 2022 Chlorobisphenol A (ClxBPA) is a kind of novel estrogenic compounds. The present study aims to investigate the effects of three ClxBPA compounds on the kisspeptin/G protein-coupled receptor 54 (GPR54, also named KissR1)-gonadotropin-releasing hormone ...
Bingli Lei +5 more
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