Results 51 to 60 of about 4,592 (135)

Stroke Increases G Protein-Coupled Estrogen Receptor Expression in the Brain of Male but Not Female Mice

Neurosignals, 2012
The novel estrogen receptor, G protein-coupled estrogen receptor (GPER, previously named GPR30), is widely distributed throughout the male and female brain and, thus, could potentially play a role in estrogen-mediated neuroprotective effects in diseases ...
Brad R.S. Broughton, Vanessa H. Brait, Elizabeth Guida, Seyoung Lee, Thiruma V. Arumugam, Chantelle V. Gardiner-Mann, Alyson A. Miller, Sung-Chun Tang, Grant R. Drummond, Christopher G. Sobey   +9 more
doaj   +1 more source

Multi‐Omics Landscape of Paraspinal Muscles in Spinal Muscular Atrophy With Scoliosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Most spinal muscular atrophy (SMA) patients develop severe scoliosis by late adolescence. Given that the paraspinal muscles—particularly the multifidus—are indispensable for maintaining spinal stability, their site‐specific multi‐omics characteristics in SMA remain insufficiently defined. Herein, integrated multi‐omics sequencing was performed
Zhen Wang, Junduo Zhao, Xu'an Huang, Weiyun Chen, Jianxiong Shen   +4 more
wiley   +1 more source

Regulatory mechanisms of the Hippo/YAP axis by G-protein coupled estrogen receptor in gastric signet-ring cell carcinoma

Neoplasia: An International Journal for Oncology Research
Although aberrant activation of the Hippo/YAP axis has been implicated in the development of gastric cancer, functional studies of this cascade in the context of gastric signet-ring cell carcinoma (GSRC) remain absent. Our previous single-cell sequencing
Yufei Wang, Yuanlin Sun, Weizhu Zhao, Jiazi Zhang, Xiaofeng Wang, Fangqi Hu, Zhifei Han, Longgang Wang, Luguang Liu, Bing Liu, Liqing Liu, Bo Bi, Dong Sun, Bingtian Liu, Jie Chai   +14 more
doaj   +1 more source

Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation.

Frontiers in Pharmacology, 2015
Aldosterone promotes non-genomic effects in endothelial and vascular smooth muscle cells via activation of mineralocorticoid receptors (MR) and G protein-coupled estrogen receptors (GPER).
Nathanne Santos Ferreira, Stêfany Bruno Assis Cau, Marcondes Alves Barbosa Silva, Carla Pavan Manzato, Fabíola Leslie Antunes Cardoso Mestriner, Takayuki eMatsumoto, Fernando Silva Carneiro, Rita Cassia Tostes   +7 more
doaj   +1 more source

APOE4 negates the effects of ovarian hormones on cerebrovascular endothelial and mitochondrial function

The Journal of Physiology, Volume 604, Issue 14, Page 5853-5873, 15 July 2026.
Abstract figure legend We examined the interaction effect of ovarian hormones and APOE genotype on cerebrovascular and mitochondrial function. Our data revealed that APOEε3 mice that were ovariectomized exhibited impaired endothelial function and greater oxidative stress and inflammation compared to sham controls.
Mackenzie N. Kehmeier, Alexandra Famiano, Abigail E. Cullen, Thomas Leonhardt, Skylyn J. Ferguson, Madeleine Snyder, Carrie E. McCurdy, Daniel J. Tyrrell, Nabil J. Alkayed, Ashley E. Walker   +9 more
wiley   +1 more source

Role of G Protein-Coupled Estrogen Receptor in The Regulatory Effects of Phytoestrogens on Prostate Cancer Cell Migration and Invasion [PDF]

Cell Journal
Isoflavones are phytoestrogen compounds that can regulate the growth of prostate cancer (PCa) cells. While most studies indicate phytoestrogens mediate their biological effects by activating estrogen receptors (ERs) ERα and ERβ, recent research suggests ...
Cecilia Rico Fuentes, Adrián Ramírez de Arellano, Ana Laura Pereira Suarez, Julio Cesar Villegas Pineda, Juan Manuel Guzman Flores, Edgar Ivan Lopez Pulido   +5 more
doaj   +1 more source

Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid, Irakli Kopaliani, Birgit Zatschler, Ansam Seif, Stephan Speier, Andreas Deussen   +5 more
wiley   +1 more source

Estrogen receptor β regulates sex‐dependent airway mechanics and inflammation in a murine model of allergen exposure

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Sex differences in asthma severity have been reported; however, the specific contribution of estrogen receptor β (ERβ) remains incompletely defined. We tested the hypothesis that ERβ modulates sex‐specific physiological responses to chronic allergen exposure using C57BL/6J wild‐type (WT) and ERβ‐deficient (Esr2−/−) male and female mice ...
Carolyn Damilola Ekpruke, Dustin Rousselle, Maksat Babayev, Omar Borges‐Sosa, Rachel Alford, Lyidia Dinwiddie, David Michael Merritt, Christopher Michael Hemmerich, Douglas B. Rusch, Sarah Bradley, Matthew Louis Retzner, Erik Parker, Patricia Silveyra   +12 more
wiley   +1 more source

Estrogen as a therapeutic agent: Targeting endotheliopathy and coagulopathy in trauma

Transfusion, Volume 66, Issue S1, Page S224-S232, May 2026.
Abstract Background Traumatic injury remains a leading cause of death, often due to uncontrolled hemorrhage and trauma‐induced coagulopathy (TIC). TIC is critically triggered by the endotheliopathy of trauma, involving endothelial cell injury and glycocalyx degradation. Despite conventional advances, the stable casualty rate underscores the urgent need
Niruktha Raghavan, Mira Patel, Bryan A. Cotton, Julia Coleman, Donald Jenkins   +4 more
wiley   +1 more source

GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior

Neural Plasticity, 2020
Ample evidence suggests that estrogens have strong influences on the occurrence of stress-related mood disorders, but the underlying mechanisms remain poorly understood.
Yi Zheng, Meimei Wu, Ting Gao, Li Meng, Xiaowei Ding, Youqiang Meng, Yingfu Jiao, Ping Luo, Zhenquan He, Tao Sun, Guohua Zhang, Xueyin Shi, Weifang Rong   +12 more
doaj   +1 more source