Results 51 to 60 of about 10,884 (213)
GPER: An Estrogen Receptor Key in Metastasis and Tumoral Microenvironments
International Journal of Molecular Sciences, 2023 Estrogens and their role in cancer are well-studied, and some cancer types are classified in terms of their response to them. In recent years, a G protein-coupled estrogen receptor (GPER) has been described with relevance in cancer. GPER is a pleiotropic receptor with tissue-specific activity; in normal tissues, its activation is related to correct ...
Ana Carolina Tirado-Garibay +3 more
openaire +2 more sources
Cell Death Discovery, 2023 The G protein-coupled estrogen receptor (GPER) mediates estrogen action in different pathophysiological conditions, including cancer. GPER expression and signaling have been found to join in the progression of triple-negative breast cancer (TNBC), even ...
Francesca Cirillo +17 more
doaj +1 more source
17,β-estradiol inhibits hepatitis C virus mainly by interference with the release phase of its life cycle [PDF]
, 2016 Rationale & Aim: Estrogen and estrogen-mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of HCV life cycle is/are affected by estrogens.
Barbaglia, Matteo N. +10 more
core +2 more sources
Cellular Physiology and Biochemistry, 2017 Background/Aims: The targeted therapy for triple-negative breast cancer (TNBC) is still challenging due to poor understanding on its molecular etiology.
Yan Shen +5 more
doaj +1 more source
Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]
, 2018 Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille +12 more
core +2 more sources
GPER was associated with hypertension in post-menopausal women
Open Medicine, 2018 Abstract Objective To explore the relationship between G protein-coupled estrogen receptor (GPER) and hypertension in post-menopausal women. Methods Using a matched case-control design, clinical and laboratory data were collected ...
Liu Shichao +3 more
openaire +3 more sources
Scientific ReportsType 2 diabetes mellitus (T2D) causes gastroparesis, delayed intestinal transit, and constipation, for unknown reasons. Complications are predominant in women than men (particularly pregnant and postmenopausal women), suggesting a female hormone-mediated
Aliyu Muhammad +8 more
doaj +1 more source
Biomolecules & Biomedicine, 2018 Estrogen has a crucial role in the regulation of reproductive and neuroendocrine function and exerts its effects through two classes of receptors, nuclear and membrane estrogen receptors (mERs).
Nilfer Sahin +3 more
doaj +1 more source
, 2009 There exist two central measures of turbulent mixing in turbulent stratified fluids, both caused by molecular diffusion: 1) the dissipation rate D(APE) of available potential energy (APE); 2) the turbulent rate of change Wr,turbulent of background ...
Tailleux, Remi
core +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source