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GPER–novel membrane oestrogen receptor [PDF]
Clinical Science, 2016 The recent discovery of the G protein-coupled oestrogen receptor (GPER) presents new challenges and opportunities for understanding the physiology, pathophysiology and pharmacology of many diseases. This review will focus on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure ...
Margaret A, Zimmerman +3 more
openaire +2 more sources
Emerging roles of GPER in diabetes and atherosclerosis [PDF]
Trends in Endocrinology & Metabolism, 2015 The G protein-coupled estrogen receptor (GPER) is a 7-transmembrane receptor implicated in rapid estrogen signaling. Originally cloned from vascular endothelial cells, GPER plays a central role in the regulation of vascular tone and cell growth as well as lipid and glucose homeostasis.
Barton M, Prossnitz ER
openaire +3 more sources
GPER as a Receptor for Endocrine-Disrupting Chemicals (EDCs) [PDF]
Frontiers in Endocrinology, 2020 Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with endogenous hormonal systems at various levels, resulting in adverse health effects. EDCs belong to diverse chemical families and can accumulate in the environment, diet and body fluids, with different levels of persistence.
Périan, Séverine, Vanacker, Jean-Marc
openaire +4 more sources
GPER-Induced ERK Signaling Decreases Cell Viability of Hepatocellular Carcinoma
Frontiers in Oncology, 2021 Hepatocellular carcinoma (HCC) is an aggressive malignancy with a poor prognosis. Effective biomarkers and specific therapeutic targets for HCC are therefore urgently needed.
Yu-an Qiu +14 more
doaj +1 more source
GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo [PDF]
, 2015 We have previously demonstrated that estrogen receptor (ER) alpha (ESR1) increases proliferation of adrenocortical carcinoma (ACC) through both an estrogen-dependent and -independent (induced by IGF-II/IGF1R pathways) manner.
Amendola, Donatella +16 more
core +2 more sources
A convex formulation for voltage unbalance compensation problem on hybrid microgrids
Revista Principia, 2019 Voltage unbalance is a power quality condition that arises due to the presence of unbalanced single-phase loads. The presence of voltage unbalances affects negatively a series of sensible equipment and, therefore, is undesirable.
José Diogo Forte de Oliveira Luna +2 more
doaj +1 more source
Reproductive Medicine and Biology, 2021 Purpose To investigate the role of estrogen receptors (ERs) in high‐grade serous carcinoma (HGSC) and clear cell carcinoma (CCC) of the ovary and evaluate ERs as prognostic biomarkers for ovarian cancer. Methods This study included 79 patients with HGSC (
Daiken Osaku +8 more
doaj +1 more source
Estrogen, angiogenesis, immunity and cell metabolism: Solving the puzzle [PDF]
, 2018 Estrogen plays an important role in the regulation of cardiovascular physiology and the immune system by inducing direct effects on multiple cell types including immune and vascular cells. Sex steroid hormones are implicated in cardiovascular protection,
Bolego, Chiara +5 more
core +4 more sources
Evidence for G‐Protein–Coupled Estrogen Receptor as a Pronatriuretic Factor
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background The novel estrogen receptor, G‐protein–coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt‐induced complications, yet there is no ...
Eman Y. Gohar +11 more
doaj +1 more source
Duplicated membrane estrogen receptors in the European sea bass (Dicentrarchus labrax): Phylogeny, expression and regulation throughout the reproductive cycle [PDF]
, 2018 The numerous estrogen functions reported across vertebrates have been classically explained by their binding to specific transcription factors, the nuclear estrogen receptors (ERs).
Alvarado, M. Victoria +5 more
core +1 more source