Results 21 to 30 of about 4,592 (135)

Prognostic role of GPER/Ezrin in triple-negative breast cancer is associated with menopausal status

Endocrine Connections, 2019
The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC).
Shuang Ye, Yuanyuan Xu, Jiehao Li, Shuhui Zheng, Peng Sun, Tinghuai Wang   +5 more
doaj   +1 more source

GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathway

Cell Death Discovery, 2023
The G protein-coupled estrogen receptor (GPER) mediates estrogen action in different pathophysiological conditions, including cancer. GPER expression and signaling have been found to join in the progression of triple-negative breast cancer (TNBC), even ...
Francesca Cirillo, Marianna Talia, Maria Francesca Santolla, Michele Pellegrino, Domenica Scordamaglia, Asia Spinelli, Salvatore De Rosis, Francesca Giordano, Lucia Muglia, Azzurra Zicarelli, Marika Di Dio, Damiano Cosimo Rigiracciolo, Anna Maria Miglietta, Gianfranco Filippelli, Ernestina Marianna De Francesco, Antonino Belfiore, Rosamaria Lappano, Marcello Maggiolini   +17 more
doaj   +1 more source

Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors

Journal of Immunology Research, 2016
The G-protein-coupled estrogen receptor-1 (GPER-1), also known as GPR30, is a novel estrogen receptor mediating estrogen receptor signaling in multiple cell types.
Hongyan Qian, Jingxiu Xuan, Yuan Liu, Guixiu Shi   +3 more
doaj   +1 more source

Effect of G-protein-coupled Estrogen Receptor on Prognosis and Clinicopathological Characteristics of Patients with Breast Cancer: A Systematic Meta-analysis

Zhongliu Fangzhi Yanjiu, 2023
Objective In this study, a meta-analysis of the expression of G-protein-coupled estrogen receptor (GPER) in breast cancer (BC) and its role in prognosis was conducted to understand the effect of this expression on the survival and clinicopathological ...
LIU Longjiao, YAO Yufeng
doaj   +1 more source

The spatial and temporal pattern of GPER/GPR30 reporter expression in the developing and mature forebrain of mice

Brain Research Bulletin
Evidence suggest that estrogens play crucial roles in the regulation of neural development and function and the G protein-coupled estrogen receptor (GPER/GPR30) appears to be the predominant estrogen receptor in the brain.
Meimei Wu, Wenxin He, Huashan Gong, Li Dong, Na Ding, Guohua Zhang, Jing Wang, Weifang Rong   +7 more
doaj   +1 more source

Sex-specific epigenetics drive low GPER expression in gastrointestinal smooth muscles in type 2 diabetic mice

Scientific Reports
Type 2 diabetes mellitus (T2D) causes gastroparesis, delayed intestinal transit, and constipation, for unknown reasons. Complications are predominant in women than men (particularly pregnant and postmenopausal women), suggesting a female hormone-mediated
Aliyu Muhammad, Juanita C. Hixon, Abdurrahman Pharmacy Yusuf, Jatna I. Rivas Zarete, India Johnson, Jamial Miller, Benjamin Adu-Addai, Clayton Yates, Sunila Mahavadi   +8 more
doaj   +1 more source

Current progress and prospects for G protein-coupled estrogen receptor in triple-negative breast cancer

Frontiers in Cell and Developmental Biology
Triple-negative breast cancer (TNBC) is a biologically and clinically heterogeneous disease. The G protein-coupled estrogen receptor (GPER) plays a crucial role in mediating the effect of estrogen and estrogen-like compounds in TNBC cells.
Duo Zhang, Hong Chen, Jinpeng Wang, Jiale Ji, Murshid Imam, Zhijie Zhang, Shunchao Yan   +6 more
doaj   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

Evaluation of estrogen and G protein-coupled estrogen receptor 1 (GPER) levels in drug-naïve patients with attention deficit hyperactivity disorder (ADHD)

Biomolecules & Biomedicine, 2018
Estrogen has a crucial role in the regulation of reproductive and neuroendocrine function and exerts its effects through two classes of receptors, nuclear and membrane estrogen receptors (mERs).
Nilfer Sahin, Hatice Altun, Ergül Belge Kurutaş, Ebru Fındıklı   +3 more
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source