Results 11 to 20 of about 4,592 (135)

Differential expression of estrogen receptor subtypes in ovarian high‐grade serous carcinoma and clear cell carcinoma

Reproductive Medicine and Biology, 2021
Purpose To investigate the role of estrogen receptors (ERs) in high‐grade serous carcinoma (HGSC) and clear cell carcinoma (CCC) of the ovary and evaluate ERs as prognostic biomarkers for ovarian cancer. Methods This study included 79 patients with HGSC (
Daiken Osaku, Tetsuro Oishi, Naoshi Kawamura, Yuki Iida, Hiroaki Komatsu, Akiko Kudoh, Jun Chikumi, Shinya Sato, Tasuku Harada   +8 more
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GPER-Induced ERK Signaling Decreases Cell Viability of Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is an aggressive malignancy with a poor prognosis. Effective biomarkers and specific therapeutic targets for HCC are therefore urgently needed.
Yu-an Qiu, Yu-an Qiu, Jianping Xiong, Qin Fu, Yun Dong, Manran Liu, Meixi Peng, Wenjian Jin, Lixia Zhou, Xue Xu, Xianming Huang, Airong Fu, Guohui Xu, Gang Tu, Tenghua Yu   +14 more
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Neonicotinoid insecticides promote breast cancer progression via G protein-coupled estrogen receptor: In vivo, in vitro and in silico studies

Environment International, 2022
Neonicotinoid insecticides (NIs) have been widely detected in environmental media and human body with concentrations reaching hundreds of nanomolar to micromolar levels.
Xin Li, Sen He, Han Xiao, Ting-Ting He, Jia-Da Zhang, Zi-Rui Luo, Jie-Zhi Ma, Yu-Long Yin, Lin Luo, Lin-Ying Cao   +9 more
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The G protein-coupled estrogen receptor (GPER) is expressed in two different subcellular localizations reflecting distinct tumor properties in breast cancer. [PDF]

PLoS ONE, 2014
INTRODUCTION:The G protein-coupled estrogen receptor (GPER) is a novel estrogen receptor that mediates proliferative effects induced by estrogen but also by tamoxifen.
Eleftherios P Samartzis, Aurelia Noske, Alexander Meisel, Zsuzsanna Varga, Daniel Fink, Patrick Imesch   +5 more
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Cryptotanshinone inhibits proliferation and induces apoptosis of breast cancer MCF-7 cells via GPER mediated PI3K/AKT signaling pathway.

PLoS ONE, 2022
G protein-coupled estrogen receptor (GPER) was reported to be a potential target in the breast cancer therapy. This study aimed to illuminate the function of GPER and its mediated PI3K/AKT pathway in cryptotanshinone (CPT) inducing cell apoptosis and ...
Danning Shi, Hongbo Li, Zeye Zhang, Yueshuang He, Meng Chen, Liping Sun, Piwen Zhao   +6 more
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The G protein-coupled estrogen receptor 1 (GPER/GPR30) does not predict survival in patients with ovarian cancer

Journal of Ovarian Research, 2012
Background Even though ovarian tumors are not generally considered estrogen-sensitive, estrogens may still have an impact on ovarian tumor progression. The recently identified trans-membrane estrogen receptor GPER is involved in rapid estrogen signaling.
Kolkova Zuzana, Casslén Vera, Henic Emir, Ahmadi Sara, Ehinger Anna, Jirström Karin, Casslén Bertil   +6 more
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Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance

The Journal of Clinical Investigation, 2023
The rostral ventromedial medulla (RVM) exerts bidirectional descending modulation of pain attributable to the activity of electrophysiologically identified pronociceptive ON and antinociceptive OFF neurons.
Yingfu Jiao, Po Gao, Li Dong, Xiaowei Ding, Youqiang Meng, Jiahong Qian, Ting Gao, Ruoxi Wang, Tao Jiang, Yunchun Zhang, Dexu Kong, Yi Wu, Sihan Chen, Saihong Xu, Dan Tang, Ping Luo, Meimei Wu, Li Meng, Daxiang Wen, Changhao Wu, Guohua Zhang, Xueyin Shi, Weifeng Yu, Weifang Rong   +23 more
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Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30. [PDF]

PLoS ONE, 2012
The discovery of the G protein-coupled estrogen receptor GPER (also GPR30) and the resulting development of selective chemical probes have revealed new aspects of estrogen receptor biology.
Ritwik Burai, Chinnasamy Ramesh, Tapan K Nayak, Megan K Dennis, Bj K Bryant, Eric R Prossnitz, Jeffrey B Arterburn   +6 more
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The Role of G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology

Biomolecules, 2023
Objective: Estrogen is indispensable in health and disease and mainly functions through its receptors. The protection of the cardiovascular system by estrogen and its receptors has been recognized for decades.
Fujie Xu, Jipeng Ma, Xiaowu Wang, Xiaoya Wang, Weiyi Fang, Jingwei Sun, Zilin Li, Jincheng Liu   +7 more
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The Peptide ERα17p Is a GPER Inverse Agonist that Exerts Antiproliferative Effects in Breast Cancer Cells

Cells, 2019
The inhibition of the G protein-coupled estrogen receptor (GPER) offers promising perspectives for the treatment of breast tumors. A peptide corresponding to part of the hinge region/AF2 domain of the human estrogen receptor α (ERα17p, residues 295–311 ...
Rosamaria Lappano, Christophe Mallet, Bruno Rizzuti, Fedora Grande, Giulia Raffaella Galli, Cillian Byrne, Isabelle Broutin, Ludivine Boudieu, Alain Eschalier, Yves Jacquot, Marcello Maggiolini   +10 more
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