Results 11 to 20 of about 10,884 (213)

GPER-1 acts as a tumor suppressor in ovarian cancer [PDF]

Journal of Ovarian Research, 2013
Background: It is known that the new membrane-bound estrogen receptor GPER-1 acts suppressive in breast cancer cells and its expression decreases during disease progression.
Costa, Serban-Dan, Ignatov, Atanas, Ignatov, Tanja, Kalinski, Thomas, Modl, Saskia, Ortmann, Olaf, Thulig, Maike, Treeck, Oliver, Weißenborn, Christine, Zenclussen, Ac   +9 more
core   +6 more sources

GPER and Testicular Germ Cell Cancer [PDF]

Frontiers in Endocrinology, 2021
The G protein-coupled estrogen receptor (GPER), also known as GPR30, is a widely conserved 7-transmembrane-domain protein which has been identified as a novel 17β-estradiol-binding protein that is structurally distinct from the classic oestrogen receptors (ERα and ERβ). There are still conflicting data regarding the exact role and the natural ligand of
Nicolas Chevalier, Nicolas Chevalier, Charlotte Hinault, Charlotte Hinault, Stephan Clavel, Rachel Paul-Bellon, Patrick Fenichel, Patrick Fenichel   +7 more
openaire   +3 more sources

GPER involvement in inflammatory pain

Steroids, 2023
Chronic pain is a worldwide refractory health disease that causes major financial and emotional burdens and that is devastating for individuals and society. One primary source of pain is inflammation. Current treatments for inflammatory pain are weakly effective, although they usually replace analgesics, such as opioids and non-steroidal anti ...
Jouffre, Baptiste, Acramel, Alexandre, Jacquot, Yves, Daulhac, Laurence, Mallet, Christophe   +4 more
openaire   +2 more sources

Estrogen Induced Regulation of Mucosal-Associated Invariant T Cells in Asthma. [PDF]

J Immunol Res
Asthma affects over 300 million people worldwide, with increasing rates annually. Males have higher asthma prevalence in adolescence, while females exhibit higher rates in adulthood. Reduced mucosal‐associated invariant T (MAIT) cells are found in severe asthmatic airway disease.
Trivedi S, Aamodt SE, Huecksteadt TP, Myers EJ, McGee GH, Cacioppo JG, Aubé J, Paine R, Leung DT, Warren KJ.   +9 more
europepmc   +2 more sources

GPER signaling in spermatogenesis and testicular tumors [PDF]

Frontiers in Endocrinology, 2014
Estrogens play important roles in the regulation of testis development and spermatogenesis. Moreover, several evidences suggest that estrogen signaling can be involved in testicular tumorigenesis. The physiological effects of estrogen are mediated by the classical nuclear estrogen receptors ESR1 and 2, which regulate both genomic and rapid signaling ...
Chimento A., Sirianni R., Casaburi I., Pezzi V.   +3 more
openaire   +3 more sources

Computational Approaches for the Discovery of GPER Targeting Compounds [PDF]

Frontiers in Endocrinology, 2020
Estrogens exert a panel of biological activities mainly through the estrogen receptors α and β, which belong to the nuclear receptor superfamily. Diverse studies have shown that the G protein-coupled estrogen receptor 1 (GPER, previously known as GPR30) also mediates the multifaceted effects of estrogens in numerous pathophysiological events, including
Fedora Grande, Maria A. Occhiuzzi, Rosamaria Lappano, Francesca Cirillo, Francesca Cirillo, Rita Guzzi, Rita Guzzi, Antonio Garofalo, Yves Jacquot, Marcello Maggiolini, Bruno Rizzuti   +10 more
openaire   +3 more sources

Decreased Levels of G Protein-Coupled Estrogen Receptor in Bipolar Patients

Genel Tıp Dergisi, 2023
Objectives: There is increasing evidence in the literature that estrogen and its receptors play an important role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity and peak periods of the disease.
Nurinnisa Öztürk, Onur Hurşitoğlu, Ömer Faruk Uygur, Ergul Belge Kurutas   +3 more
doaj   +1 more source

GPER/GPR30 Knockout Mice: Effects of GPER on Metabolism [PDF]

, 2016
Endogenous estrogens, predominantly 17β-estradiol (E2), mediate various diverse effects throughout the body in both normal physiology and disease. Actions include development (including puberty) and reproduction as well as additional effects throughout life in the metabolic, endocrine, musculoskeletal, nervous, cardiovascular, and immune systems.
Geetanjali, Sharma, Eric R, Prossnitz
openaire   +2 more sources

Disruption of 3D MCF-12A breast cell cultures by estrogens - An in vitro model for ER-mediated changes indicative of hormonal carcinogenesis [PDF]

, 2012
Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and 85 reproduction in any medium, provided the original author and source
Elisabete Silva, Irina Agoulnik, Stephanie Marchese   +2 more
core   +5 more sources

High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient outcomes

npj Breast Cancer, 2022
Triple-negative breast cancer (TNBC) is a particularly aggressive and heterogeneous disease with few effective targeted therapies and precision therapeutic options over a long period. It is generally considered that TNBC is an estrogen-independent breast
Ting Xu, Ding Ma, Sheng Chen, Rui Tang, Jianling Yang, Chunhui Meng, Yang Feng, Li Liu, Jiangfen Wang, Haojun Luo, Keda Yu   +10 more
doaj   +1 more source