Results 261 to 270 of about 94,252 (292)

17β-Estradiol, through activating the G protein-coupled estrogen receptor, exacerbates the complication of benign prostatic hyperplasia in type 2 diabetes mellitus patients by inducing prostate proliferation. [PDF]

J Pharm Anal
Yang T, Qiu Z, Shen J, He Y, Yin L, Chen L, Yuan J, Liu J, Wang T, Jiang Z, Ying C, Qian S, Song J, Yin X, Lu Q.   +14 more
europepmc   +1 more source

Role of Estrogen Receptor β, G-Protein Coupled Estrogen Receptor and Estrogen-Related Receptors in Endometrial and Ovarian Cancer

Cancers, 2023
Ovarian and endometrial cancers are affected by estrogens and their receptors. It has been long known that in different types of cancers, estrogens activate tumor cell proliferation via estrogen receptor α (ERα). In contrast, the role of ERs discovered later, including ERβ and G-protein-coupled ER (GPER1), in cancer is less well understood, but the ...
Susanne Schuler-Toprak, Maciej Skrzypczak, Carsten Gründker   +2 more
exaly   +6 more sources

G-Protein Coupled Estrogen Receptor in Breast Cancer [PDF]

International Journal of Molecular Sciences, 2019
The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer.
Li-Han Hsu, Yung-Feng Lin, Shu-Huei Kao   +2 more
exaly   +3 more sources

G Protein-Coupled Receptor 30: Estrogen Receptor or Collaborator? [PDF]

Endocrinology, 2009
More than 800 G protein-coupled receptors (GPRs) are transcribed in the human genome (1). For many of these receptors, no endogenous ligand has been found, and, therefore, they are currently designated as orphan receptors. One such protein, GPR30, has been proposed to be an estrogen receptor (ER) (2,3).
Ellis R Levin
exaly   +3 more sources

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Estrogen Modulation of G-protein-coupled Receptors

Trends in Endocrinology & Metabolism, 1999
Estrogen exerts long-term effects in almost every cell through regulation of gene transcription. However, it has been known for some time that estrogen can rapidly alter neuronal firing within seconds, indicating that some cellular effects of estrogen could occur via non-genomic mechanisms.
, Kelly, , Wagner
openaire   +2 more sources

A G Protein-Coupled Receptor For Estrogen: The End Of The Search?

Molecular Interventions, 2005
The effects of estrogen on responsive cells and organismic development have long been known and well documented. Estrogen binds to the estrogen receptor, a dimer of the complex translocates to the nucleus, binds specific DNA elements and regulates the transcription of particular genes, a process that takes some time to achieve.
Ahmed, Hasbi, Brian F, O'Dowd, Susan R, George   +2 more
openaire   +2 more sources

G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane

Biochemical and Biophysical Research Communications, 2006
Recently, GPR30 was reported to be a novel estrogen receptor; however, its intracellular localization has remained controversial. To investigate the intracellular localization of GPR30 in vivo, we produced four kinds of polyclonal antibodies for distinct epitopes on GPR30. Immunocytochemical observations using anti-GPR30 antibody and anti-FLAG antibody
Takeshi, Funakoshi, Akie, Yanai, Koh, Shinoda, Michio M, Kawano, Yoichi, Mizukami   +4 more
openaire   +2 more sources

A novel transcript variant of human G-protein coupled estrogen receptor

Molecular Biology Reports, 2021
The G-protein coupled estrogen receptor (GPER) mediates short-term non-genomic effects of estrogen in diverse cell types and tissues. According to the NCBI nucleotide database, three variants of GPER are known. They are NM_001505.2 (GPER-v2), NM_001039966.1 (GPER-v3), and NM_001098201.1 (GPER-v4). Investigations on GPER expression are key to understand
Uttariya Pal, Mohan C. Manjegowda, Anil Mukund Limaye   +2 more
openaire   +2 more sources

The G protein-coupled estrogen receptor as a modulator of neoplastic transformation

Molecular and Cellular Endocrinology, 2016
Estrogens play a crucial role in the regulation of physiological and pathophysiological processes. These hormones act through specific receptors, most notably the canonical estrogen receptors α and β (ERα and ERβ) and their truncated forms as well as the G protein-coupled estrogen receptor (GPER).
Damian Jacenik, Adam I. Cygankiewicz, Wanda M. Krajewska   +2 more
openaire   +2 more sources