Results 11 to 20 of about 673,211 (215)

Regulation Role of Non-Rhodopsin G Protein-coupled Receptor Kinases on Tumor

Zhongliu Fangzhi Yanjiu, 2019
G protein-coupled receptor kinases (GRKs) are involved in a wide range of cellular physiology and pathological activities by specifically phosphorylating activated G-protein coupled receptors (GPCRs) to terminate GPCR signaling and phosphorylating non ...
LI Ruirui, JIANG Xiaoshan
doaj   +1 more source

REGA-SIGN: Development of a Novel Set of NanoBRET-Based G Protein Biosensors

Biosensors, 2023
Despite G protein-coupled receptors (GPCRs) being important theapeutic targets, the signaling properties of many GPCRs remain poorly characterized. GPCR activation primarily initiates heterotrimeric G protein signaling. To detect ligand-induced G protein
Katrijn Boon, Nathan Vanalken, Eef Meyen, Dominique Schols, Tom Van Loy   +4 more
doaj   +1 more source

Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast

Biomolecules, 2022
The yeast Saccharomyces cerevisiae has long been used to produce alcohol from glucose and other sugars. While much is known about glucose metabolism, relatively little is known about the receptors and signaling pathways that indicate glucose availability.
Shuang Li, Yuanyuan Li, Blake R. Rushing, Sarah E. Harris, Susan L. McRitchie, Daniel Dominguez, Susan J. Sumner, Henrik G. Dohlman   +7 more
doaj   +1 more source

The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54*

Journal of Biological Chemistry, 2001
Natural peptides displaying agonist activity on the orphan G protein-coupled receptor GPR54 were isolated from human placenta. These 54-, 14,- and 13-amino acid peptides, with a common RF-amide C terminus, derive from the product of KiSS-1, a metastasis ...
M. Kotani, M. Detheux, A. Vandenbogaerde, D. Communi, J. Vanderwinden, E. Le Poul, S. Brézillon, R. Tyldesley, Nathalie Suarez-Huerta, F. Vandeput, C. Blanpain, S. Schiffmann, G. Vassart, M. Parmentier   +13 more
semanticscholar   +1 more source

Free fatty acid receptors, G protein‐coupled receptor 120 and G protein‐coupled receptor 40, are essential for oil‐induced gastric inhibitory polypeptide secretion

Journal of Diabetes Investigation, 2019
Aims/Introduction Incretin hormone glucose‐dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) plays a key role in high‐fat diet‐induced obesity and insulin resistance.
Akiko Sankoda, Norio Harada, Tomoko Kato, Eri Ikeguchi, Kanako Iwasaki, Shunsuke Yamane, Yuki Murata, Akira Hirasawa, Nobuya Inagaki   +8 more
doaj   +1 more source

A G Protein-coupled Receptor Responsive to Bile Acids*

Journal of Biological Chemistry, 2003
So far some nuclear receptors for bile acids have been identified. However, no cell surface receptor for bile acids has yet been reported. We found that a novel G protein-coupled receptor, TGR5, is responsive to bile acids as a cell-surface receptor ...
Y. Kawamata, Ryo Fujii, M. Hosoya, M. Harada, Hiromi Yoshida, M. Miwa, S. Fukusumi, Y. Habata, T. Itoh, Y. Shintani, S. Hinuma, Y. Fujisawa, M. Fujino   +12 more
semanticscholar   +1 more source

Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure

Cell Reports, 2017
The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors.
James H. Felce, Sarah L. Latty, Rachel G. Knox, Susan R. Mattick, Yuan Lui, Steven F. Lee, David Klenerman, Simon J. Davis   +7 more
doaj   +1 more source

Significance of G Protein-Coupled Estrogen Receptor in the Pathophysiology of Irritable Bowel Syndrome, Inflammatory Bowel Diseases and Colorectal Cancer

Frontiers in Endocrinology, 2020
The regulatory role of estrogens and nuclear estrogen receptors, i. e., estrogen receptor α and β has been reported in gastrointestinal diseases. However, the contribution of G protein-coupled estrogen receptor, the membrane-bound estrogen receptor, is ...
Damian Jacenik, Wanda M. Krajewska
doaj   +1 more source

Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein

MedComm, 2022
GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear ...
Fang Ye, Thian‐Sze Wong, Geng Chen, Zhiyi Zhang, Binghao Zhang, Shiyi Gan, Wei Gao, Jiancheng Li, Zhangsong Wu, Xin Pan, Yang Du   +10 more
doaj   +1 more source

Competing G protein‐coupled receptor kinases balance G protein and β‐arrestin signaling

Molecular Systems Biology, 2012
Seven‐transmembrane receptors (7TMRs) are involved in nearly all aspects of chemical communications and represent major drug targets. 7TMRs transmit their signals not only via heterotrimeric G proteins but also through β‐arrestins, whose recruitment to ...
Domitille Heitzler, Guillaume Durand, Nathalie Gallay, Aurélien Rizk, Seungkirl Ahn, Jihee Kim, Jonathan D Violin, Laurence Dupuy, Christophe Gauthier, Vincent Piketty, Pascale Crépieux, Anne Poupon, Frédérique Clément, François Fages, Robert J Lefkowitz, Eric Reiter   +15 more
doaj   +1 more source