Results 331 to 340 of about 1,031,574 (396)

Quantitative approaches for studying G protein-coupled receptor signalling and pharmacology.

J Cell Sci
Pearce A, Redfern-Nichols T, Wills E, Rosa M, Manulak I, Sisk C, Huang X, Atakpa-Adaji P, Prole DL, Ladds G.   +9 more
europepmc   +1 more source

G protein-coupled receptor 35 (GPR35) stimulation reduces osteoclast activity in primary human bone cells

Price ML, Wyatt RA, Crastin A, Jamaluddin A, Hardy RS, Frost M, Gorvin CM.   +6 more
europepmc   +1 more source

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G protein-coupled receptors

Current Biology, 1992
The diversity of the G protein-coupled receptor superfamily is now being realised with the molecular cloning of DNA encoding many new receptors and receptor subfamilies. The existing pharmacological definitions of receptor subtypes have been extended dramatically with identification of additional subtypes at the molecular level.
T P, Iismaa, J, Shine
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G-Protein-Coupled Receptors

2008
G-Protein-coupled receptors mediate many of the hypnotic and analgesic actions of the drugs employed in anesthesia. Notably, opioid agonists represent the most successful and efficacious class of analgesic agents employed over the last century. Also, major clinical advances have been made by the study of alpha(2) adrenoceptor agonists, which possess ...
R D, Sanders, D, Brian, M, Maze
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G-Protein-Coupled Receptor Microarrays

ChemBioChem, 2002
Membrane-bound proteins represent the single most important class of drug targets. Arraying these proteins is difficult because they typically need to be embedded in membranes to maintain their correctly folded conformations. We describe here the fabrication of microarrays consisting of G-protein-coupled receptors (GPCRs)--the single largest family of ...
Ye, Fang, Anthony G, Frutos, Joydeep, Lahiri   +2 more
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G Protein-Coupled Receptor Pharmacogenetics

2008
Common G protein-coupled receptor (GPCR) gene variants that encode receptor proteins with a distinct sequence may alter drug efficacy without always resulting in a disease phenotype. GPCR genetic loci harbor numerous variants, such as DNA insertions or deletions and single-nucleotide polymorphisms that alter GPCR expression and function, thereby ...
Miles D, Thompson, Katherine A, Siminovitch, David E C, Cole   +2 more
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Fingerprinting G-protein-coupled receptors

"Protein Engineering, Design and Selection", 1994
Recently we reported the design of a discriminating fingerprint for rhodopsin-like G-protein-coupled receptors (GPCRs). The fingerprint encodes the seven putative membrane-spanning motifs and was potently diagnostic of all GPCRs (52 in all) in version 8.1 of the OWL composite sequence database, readily distinguishing them from all other integral ...
T K, Attwood, J B, Findlay
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G protein-Coupled Receptors

2010
Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in ...
Husseini K. Manji, Jorge Quiroz, R. Andrew Chambers, Anthony Absalom, David Menon, Patrizia Porcu, A. Leslie Morrow, Wolfgang Fleischhacker, Naheed (Max) Mirza, Christine A. Franco, Marc N. Potenza, Robert Kessler, Ronald L. Cowan, Daniel Hoyer, Eric J. Nestler, Elizabath C. Warburton, Anthony Absalom, David Menon, David S. Baldwin, Sophie Tambour, John C. Crabbe, Nicole Edgar, Etienne Sibille, Linda Lundstroem, Silvia Gatti McArthur, Will Spooren, R. H. de Rijk, E. R. De Kloet, Michael J. Owens, Chase H. Bourke, Joachim D. Uys, Peter W. Kalivas, Linda Lundstroem, Silvia Gatti McArthur, Will Spooren, Anne M. Andrews, Greg A. Gerhardt, Lynette Daws, Barbara J. Mason, Charles J. Heyser, Seiya Miyamoto, Peter Riederer, Siegfried Hoyer, Suzanne H. Mitchell, Harriet de Wit, Matthew I. Palmatier, Rick A. Bevins, Jill B. Becker, C. Neill Epperson, Gorkem Yararbas, Sakire Pogun, Michael M. Morgan, MacDonald J. Christie, Michael M. Morgan, MacDonald J. Christie, Ben J. Harrison, Christos Pantelis, Seiya Miyamoto, Andrew Young   +58 more
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G protein—coupled receptor kinases

Cell, 1993
G protein‐coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein‐coupled receptors (GPCRs) as their primary substrates. GRK-mediated receptor phosphorylation rapidly initiates profound impairment of receptor signaling, or desensitization.
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G‐Protein–Coupled Receptor Deorphanizations

2005
G protein–coupled receptors (GPCRs) are major regulators of intercellular interactions. They initiate these actions by being activated by a wide variety of natural ligands. Historically, ligands were discovered first, but the advent of molecular biology reversed this trend.
Yumiko, Saito, Olivier, Civelli
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