Results 81 to 90 of about 728,478 (309)

GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis

Stem Cell Reports, 2016
Hematopoietic stem cells (HSCs) originate from hemogenic endothelium within the aorta-gonad-mesonephros (AGM) region of the mammalian embryo. The relationship between genetic circuits controlling stem cell genesis and multi-potency is not understood.
Xin Gao, Tongyu Wu, Kirby D. Johnson, Jamie L. Lahvic, Erik A. Ranheim, Leonard I. Zon, Emery H. Bresnick   +6 more
doaj   +1 more source

Structure of the full-length glucagon class B G protein-coupled receptor

Nature, 2017
The human glucagon receptor, GCGR, belongs to the class B G-protein-coupled receptor family and plays a key role in glucose homeostasis and the pathophysiology of type 2 diabetes.
Haonan Zhang, A. Qiao, Dehua Yang, Linlin Yang, A. Dai, C. de Graaf, S. Reedtz-Runge, V. Dharmarajan, Hui Zhang, G. Han, T. Grant, R. Sierra, U. Weierstall, G. Nelson, Wei Liu, Yanhong Wu, Limin Ma, Xiao-qing Cai, Guang-yao Lin, Xiaoai Wu, Zhi Geng, Yuhui Dong, Gaojie Song, P. Griffin, J. Lau, V. Cherezov, Huaiyu Yang, M. Hanson, R. Stevens, Qiang Zhao, Hualiang Jiang, Ming-Wei Wang, Beili Wu   +32 more
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Whole body deletion of Gpr68 does not change hematopoietic stem cell function

Stem Cell Research, 2020
G protein-coupled receptor 68 (GPR68) responds to extracellular protons, thus called the proton-sensing G protein-coupled receptor (GPCR), leading to activation of the phospholipase C-β (PLCβ)/calcium (Ca2+) pathway or the adenylyl cyclase (AC)/cyclic ...
Xiaofei He, Caleb Hawkins, Lauren Lawley, Kennedy Freeman, Tra Mi Phan, Jiajia Zhang, Yan Xu, Jing Fang   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk

Cell Reports
Summary: Cellular signaling involves a large repertoire of membrane receptors operating in overlapping spatiotemporal regimes and targeting many common intracellular effectors.
Cristina Lao-Peregrin, Guoqing Xiang, Jihye Kim, Ipsit Srivastava, Alexandra B. Fall, Danielle M. Gerhard, Piia Kohtala, Daegeon Kim, Minseok Song, Mikel Garcia-Marcos, Joshua Levitz, Francis S. Lee   +11 more
doaj   +1 more source

Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis

Nature Communications, 2017
Bone loss is common in patients with diabetes, but the underlying molecular and cellular mechanisms are unclear. Here the authors show high succinate levels in mice with type 2 diabetes and that succinate can signal through succinate receptor 1 on ...
Yuqi Guo, Chengzhi Xie, Xiyan Li, Jian Yang, Tao Yu, Ruohan Zhang, Tianqing Zhang, Deepak Saxena, Michael Snyder, Yingjie Wu, Xin Li   +10 more
doaj   +1 more source

G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.

PLoS ONE, 2017
The increase in protein activity and upregulation of G-protein coupled receptor kinase 2 (GRK2) is a hallmark of cardiac stress and heart failure. Inhibition of GRK2 improved cardiac function and survival and diminished cardiac remodeling in various ...
Philipp Schlegel, Julia Reinkober, Eric Meinhardt, Henrike Tscheschner, Erhe Gao, Sarah M Schumacher, Ancai Yuan, Johannes Backs, Patrick Most, Thomas Wieland, Walter J Koch, Hugo A Katus, Philip W Raake   +12 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Dynamic tuneable G protein-coupled receptor monomer-dimer populations

Nature Communications, 2018
Evidence suggests oligomerisation of G protein-coupled receptors in membranes, but this is controversial. Here, authors use single-molecule and ensemble FRET, and spectroscopy to show that the neurotensin receptor 1 forms multiple dimer conformations ...
Patricia M. Dijkman, Oliver K. Castell, Alan D. Goddard, Juan C. Munoz-Garcia, Chris de Graaf, Mark I. Wallace, Anthony Watts   +6 more
doaj   +1 more source