Results 161 to 170 of about 522,827 (307)

G-Protein–Coupled Receptor Kinase 2 as a Potential Modulator of the Hallmarks of Cancer

Molecular Pharmacology, 2017
Laura Nogués, Clara Reglero, Verónica Rivas, María Neves, P. Penela, Federico Mayor   +5 more
semanticscholar   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Retracted: G-Protein-Coupled Receptor Kinase-Interacting Protein 1 (GIT1) Promotes Head and Neck Squamous Cell Carcinoma Metastases via Activating the PI3K/AKT/mTOR Signal Pathway. [PDF]

Comput Math Methods Med, 2023
Methods In Medicine CAM.
europepmc   +1 more source

G protein-coupled receptor kinase 4 gene variants in human essential hypertension

Proceedings of the National Academy of Sciences of the United States of America, 2002
R. Felder, H. Sanada, Jing Xu, P. Yu, Z. Wang, H. Watanabe, L. Asico, Wei Wang, S. Zheng, I. Yamaguchi, Scott M. Williams, J. Gainer, N. Brown, D. Hazen‐Martin, Lee-Jun C. Wong, J. Robillard, R. Carey, G. Eisner, P. Jose   +18 more
semanticscholar   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1. [PDF]

Blood Adv, 2022
Downes K, Zhao X, Gleadall NS, McKinney H, Kempster C, Batista J, Thomas PL, Cooper M, Michael JV, Kreuzhuber R, Wedderburn K, Waller K, Varney B, Verdier H, Kriek N, Ashford SE, Stirrups KE, Dunster JL, McKenzie SE, Ouwehand WH, Gibbins JM, Yang J, Astle WJ, Ma P.   +23 more
europepmc   +1 more source

The complex G protein‐coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets

British Journal of Pharmacology, 2010
P. Penela, C. Murga, C. Ribas, V. Lafarga, Federico Mayor, Jr.   +4 more
semanticscholar   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin. [PDF]

J Biol Chem, 2022
Varney MJ, Steyaert W, Coucke PJ, Delanghe JR, Uehling DE, Joseph B, Marcellus R, Al-Awar R, Benovic JL.   +8 more
europepmc   +1 more source

The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling.

Biochimica et Biophysica Acta, 2007
C. Ribas, P. Penela, C. Murga, Alicia Salcedo, C. García-Hoz, María Jurado-Pueyo, I. Aymerich, F. Mayor   +7 more
semanticscholar   +1 more source