Results 191 to 200 of about 426,123 (306)

Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site. [PDF]

PLoS One, 2021
Stegen M, Engler A, Ochsenfarth C, Manthey I, Peters J, Siffert W, Frey UH.   +6 more
europepmc   +1 more source

Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor

, 2020
Guozhang Xu, Michael D. Gaul, Zhi‐Jie Liu, Renée L. DesJarlais, Jenson Qi, Weixue Wang, Daniel J. Krosky, Ioanna P. Petrounia, Cynthia Milligan, An N. Hermans, Hua-Rong Lu, Devine Zheng Huang, June Xu, John Spurlino   +13 more
openalex   +1 more source

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. [PDF]

J Med Chem, 2021
Rowlands RA, Chen Q, Bouley RA, Avramova LV, Tesmer JJG, White AD.   +5 more
europepmc   +1 more source

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

Potent, Selective, and Drug-Like G Protein-Coupled Receptor Kinase 5 and 6 Inhibitors: Design, Synthesis, and X-Ray Structural Studies. [PDF]

ChemMedChem
Ghosh AK, Gadi RK, Chen Y, Gamage SP, McCauley KP, Tesmer JJG.   +5 more
europepmc   +1 more source

G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure. [PDF]

Cardiovasc Res, 2022
de Lucia C, Grisanti LA, Borghetti G, Piedepalumbo M, Ibetti J, Lucchese AM, Barr EW, Roy R, Okyere AD, Murphy HC, Gao E, Rengo G, Houser SR, Tilley DG, Koch WJ.   +14 more
europepmc   +1 more source

Distinct Cellular and Subcellular Distributions of G Protein-Coupled Receptor Kinase and Arrestin Isoforms in the Striatum

, 2012
Э.Р. Бычков, Lilia Zurkovsky, Mika B. Garret, M. Rafiuddin Ahmed, Eugenia V. Gurevich   +4 more
openalex   +2 more sources

The palmitoyl acyltransferase DHHC5 mediates beta-adrenergic signaling in the heart by targeting Gα proteins and G protein-coupled receptor kinase 2 [PDF]

, 2018
Jessica J. Chen, Autumn N. Marsden, Askar M. Akimzhanov, Darren Boehning   +3 more
openalex   +1 more source

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source