Results 31 to 40 of about 427,218 (207)

Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway

Journal of Ginseng Research, 2019
Background: Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase–mediated pathway.
Quan-Gui Gao, Li-Ping Zhou, Vien Hoi-Yi Lee, Hoi-Yi Chan, Cornelia Wing-Yin Man, Man-Sau Wong   +5 more
doaj   +1 more source

Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment.

Frontiers in Pharmacology, 2014
Opioids are intensely addictive, and cessation of their chronic use is associated with a highly aversive withdrawal syndrome. A cellular hallmark of withdrawal is an opioid sensitive protein kinase A-dependent increase in GABA transporter-1 (GAT-1 ...
Elena Elizabeth Bagley
doaj   +1 more source

Disentangling bias between Gq, GRK2, and arrestin3 recruitment to the M3 muscarinic acetylcholine receptor

eLife, 2021
G protein-coupled receptors (GPCRs) transmit extracellular signals to the inside by activation of intracellular effector proteins. Different agonists can promote differential receptor-induced signaling responses – termed bias – potentially by eliciting ...
Anja Flöser, Katharina Becker, Evi Kostenis, Gabriele König, Cornelius Krasel, Peter Kolb, Moritz Bünemann   +6 more
doaj   +1 more source

Multiple regulatory domains on the Byr2 protein kinase [PDF]

, 1997
Byr2 protein kinase, a homolog of mammalian mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEKK) and Saccharomyces cerevisiae STE11, is required for pheromone-induced sexual differentiation in the fission yeast ...
Tu, H., Barr, M., Dong, D. L., Wigler, M. H.   +3 more
core   +1 more source

Homologous and Heterologous Phosphorylations of Human Histamine H1 Receptor in Intact Cells

Journal of Pharmacological Sciences, 2004
Homologous and heterologous phosphorylations of histamine H1 receptor (H1R) in intact cells were investigated using Chinese hamster ovary cells stably co-expressing c-myctagged human histamine H1 and muscarinic M3 receptors. Increase in histamine-induced
Katsuhiro Miyoshi, Nozomi Kawakami, Shuhei Horio, Hiroyuki Fukui   +3 more
doaj   +1 more source

ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. [PDF]

, 2012
The sorting of signaling receptors to lysosomes is an essential regulatory process in mammalian cells. During degradation, receptors are modified with ubiquitin and sorted by endosomal sorting complex required for transport (ESCRT)-0, -I, -II, and -III ...
Chen, Buxin, Dores, Michael R, Lin, Huilan, Meerloo, Timo, Montagne, William A, Paing, May M, Soh, Unice JK, Trejo, JoAnn   +7 more
core   +3 more sources

Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. [PDF]

, 2018
G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in a broad range of physiological responses and disease states. Activated GPCRs can undergo agonist-induced phosphorylation by G protein receptor kinases (GRKs) and second ...
Chowdhury, Dhrubajyoti, Deng, Yawen, Hell, Johannes W, Navedo, Manuel F, Nieves-Cintron, Madeline, Qi, Jinyi, Shen, Ao, Shi, Qian, Xiang, Yang K   +8 more
core   +3 more sources

Molecular insights into kinase mediated signaling pathways of chemokines and their cognate G protein coupled receptors

Frontiers in Bioscience-Landmark, 2020
Chemokines are small regulatory proteins that play a crucial role in the coordinated migration of cell populations to the site of infection/inflammation by binding to their cognate receptors.
Deepak Kumar Tripathi, Krishna Mohan Poluri   +1 more
doaj   +1 more source

Chlorobisphenol A activated kisspeptin/GPR54-GnRH neuroendocrine signals through ERα and GPER pathway in neuronal GT1-7 cells

Ecotoxicology and Environmental Safety, 2022
Chlorobisphenol A (ClxBPA) is a kind of novel estrogenic compounds. The present study aims to investigate the effects of three ClxBPA compounds on the kisspeptin/G protein-coupled receptor 54 (GPR54, also named KissR1)-gonadotropin-releasing hormone ...
Bingli Lei, Lanbing Xu, Yaoyao Huang, Yun Liu, Mengjie Yu, Qianqian Tang   +5 more
doaj   +1 more source

Ligand-induced dynamics of heterotrimeric G protein-coupled receptor-like kinase complexes.

PLoS ONE, 2017
BackgroundArabidopsis, 7-transmembrane Regulator of G signaling protein 1 (AtRGS1) modulates canonical G protein signaling by promoting the inactive state of heterotrimeric G protein complex on the plasma membrane.
Meral Tunc-Ozdemir, Alan M Jones
doaj   +1 more source