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G Protein-Coupled Receptors in Osteoarthritis [PDF]
Frontiers in Endocrinology, 2022 Osteoarthritis (OA) is the most common chronic joint disease characterized, for which there are no available therapies being able to modify the progression of OA and prevent long-term disability. Critical roles of G-protein coupled receptors (GPCRs) have
Fanhua Wang +4 more
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Peptide ligand recognition by G protein-coupled receptors [PDF]
Frontiers in Pharmacology, 2015 The past few years have seen spectacular progress in the structure determination of G protein-coupled receptors (GPCRs). We now have structural representatives from classes A, B, C, and F.
Brian E Krumm, Reinhard eGrisshammer
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Mas-Related G-Protein-Coupled Receptors: Emerging Roles in Neuropathic Pain [PDF]
BiomoleculesMas-related G-protein-coupled receptors constitute a distinct family of GPCRs expressed in some subsets of sensory neurons and immune cells. Increasing evidence highlights their contribution to the modulation of nociceptive signaling and neuroimmune ...
Mario García-Domínguez
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Latest surface plasmon resonance advances for G protein-coupled receptors [PDF]
Journal of Pharmaceutical AnalysisG protein-coupled receptors (GPCRs) are a big family of membrane proteins which represent one of the main classes of drug targets. However, their investigation presents several challenges, among which their instability outside the membrane environment ...
Giulia De Soricellis +7 more
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Acidic Tumor Microenvironment and pH-Sensing G protein-Coupled Receptors [PDF]
Frontiers in Physiology, 2013 The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection force for cancer cell somatic ...
Calvin R. Justus +2 more
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G-Protein-Coupled Receptors [PDF]
Journal of Biological Chemistry, 1998 G-protein-coupled receptors (GPCRs) constitute a huge family of membrane receptors to numerous hormones, neurotransmitters and diverse compounds. A large part of cardiovascular and neurological pharmacology is based upon the knowledge of these receptors and on the identification of molecules able to interfere with them, in an agonistic or antagonistic ...
Tae H. Ji, Mathis Grossmann, Inhae Ji
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G protein-coupled receptors and obesity
Frontiers in Endocrinology, 2023 G protein-coupled receptors (GPCRs) have emerged as important drug targets for various chronic diseases, including obesity and diabetes. Obesity is a complex chronic disease that requires long term management predisposing to type 2 diabetes, heart ...
Alessandro Pocai
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Hemorphins Targeting G Protein-Coupled Receptors
Pharmaceuticals, 2021 Hemorphins are short peptides produced by the proteolysis of the beta subunit of hemoglobin. These peptides have diverse physiological effects especially in the nervous and the renin-angiotensin systems.
Mohammed Akli Ayoub, Ranjit Vijayan
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Advances on Mrgprs itch receptors and their ligands
Pifu-xingbing zhenliaoxue zazhi, 2023 Although histamine is an important physiologically active substance in pruritus,antihistamine drugs can only relieve a small proportion of symptoms in chronic pruritus.
Jing HU, Zhijian CAO
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Lysophospholipid G Protein-coupled Receptors [PDF]
Journal of Biological Chemistry, 2004 The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger.
Brigitte, Anliker, Jerold, Chun
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