Moving Signals and Their Measured Frequencies [PDF]
arXiv, 2012 Classical Doppler Effect of light propagation can be calculated by making any one of the two assumptions a) Light propagates at the speed c with respect to the source or b) Light propagates at the speed c with respect to the receptor. We show that the ratio of the two calculated classical Doppler Effects, with propagation speed c in the source inertial
arxiv
GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes. [PDF]
, 1993 Stephen M. Strittmatter +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou +11 more
wiley +1 more source
Regulation of G protein-coupled receptors by palmitoylation and cholesterol
BMC Biology, 2012 Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols.
Goddard Alan D, Watts Anthony
doaj +1 more source
Mutation of a highly conserved acidic residue present in the second intracellular loop of G-protein-coupled receptors does not impair hormone binding or signal transduction of the luteinizing hormone/chorionic gonadotropin receptor. [PDF]
, 1993 Z Wang, H Wang, Mario Ascoli
openalex +1 more source
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
Receptors cluster in high-curvature membrane regions for optimal spatial gradient sensing [PDF]
arXivSpatial information from cell-surface receptors is crucial for processes that require signal processing and sensing of the environment. Here, we investigate the optimal placement of such receptors through a theoretical model that minimizes uncertainty in gradient estimation.
arxiv
Schizophrenia: Normal Sequence in the Dopamine D2 Receptor Region that Couples to G-Proteins. DNA Polymorphisms in D2 [PDF]
, 1993 Philip Seeman +6 more
openalex +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors. [PDF]
, 1994 Jean‐Philippe Pin +3 more
openalex +1 more source