Results 171 to 180 of about 1,006,310 (331)

G Protein-coupled receptors as targets for drug design

Biotecnología Aplicada
G protein-coupled receptors (GPCRs) are the target for more than 50% of the drugs currently on the market, including about 25% of the 100 top-selling drugs. They are considered the most important molecules in the field of drug discovery and design today,
Ania de la Nuez Veulens, Rolando Rodríguez   +1 more
doaj  

A Proposed Structure for Transmembrane Segment 7 of G Protein-Coupled Receptors Incorporating an Asn-Pro/Asp-Pro Motif [PDF]

, 1998
Karel Konvička, Frank Guarnieri, Juan Antonio Ballesteros‐Cánovas, Harel Weinstein   +3 more
openalex   +1 more source

The structure and function of G-protein-coupled receptors

Nature, 2009
D. Rosenbaum, S. Rasmussen, B. Kobilka
semanticscholar   +1 more source

G Protein-Coupled Receptors in Cell Signaling Transduction. [PDF]

Int J Mol Sci, 2023
Beer-Hammer S, Liebscher I.
europepmc   +1 more source

Deciphering the unique dynamic activation pathway in a G protein-coupled receptor enables unveiling biased signaling and identifying cryptic allosteric sites in conformational intermediates [PDF]

arXiv
Neurotensin receptor 1 (NTSR1), a member of the Class A G protein-coupled receptor superfamily, plays an important role in modulating dopaminergic neuronal activity and eliciting opioid-independent analgesia. Recent studies suggest that promoting \{beta}-arrestin-biased signaling in NTSR1 may diminish drugs of abuse, such as psychostimulants, thereby ...
arxiv  

G-Protein-Coupled Modulation of Presynaptic Calcium Currents and Transmitter Release by a GABA_BReceptor [PDF]

, 1998
Tomoyuki Takahashi, Yoshinao Kajikawa, Tetsuhiro Tsujimoto   +2 more
openalex   +1 more source

Application of FRET- and BRET-based live-cell biosensors in deorphanization and ligand discovery studies on orphan G protein-coupled receptors

SLAS Discovery
Bioluminescence- and fluorescence-based resonance energy transfer assays have gained considerable attention in pharmacological research as high-throughput scalable tools applicable to drug discovery. To this end, G protein-coupled receptors represent the
Joanna J. Sajkowska, Choi Har Tsang, Paweł Kozielewicz   +2 more
doaj  

A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system [PDF]

, 1998
Patrick J. Donohue, Hagit Shapira, Samuel A. Mantey, Lori L. Hampton, Robert T. Jensen, James F. Battey   +5 more
openalex   +1 more source

G Protein–Coupled Receptor Kinases: Crucial Regulators of Blood Pressure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Jian Yang, Van Anthony M. Villar, Ines Armando, Pedro A. Jose, Chunyu Zeng   +4 more
doaj   +1 more source

Potential Regulatory Roles for G Protein-Coupled Receptor Kinases and -Arrestins in Gonadotropin-Releasing Hormone Receptor Signaling [PDF]

, 1998
Jimmy D. Neill
openalex   +1 more source