Results 171 to 180 of about 500,528 (216)

G-protein coupled receptors in bone

Frontiers in Bioscience, 1998
The skeleton is a dynamic structure that undergoes continuous remodeling, a prerequisite to meeting the constant loading demands placed upon it. This process is controlled by a multitude of systemic and local factors which interact with receptors presented on the surface of both osteoblasts and osteoclasts; the osteogenic and osteolytic cells of bone ...
W.B. Bowler, Graeme Bilbe, James A. Gallagher   +2 more
openaire   +3 more sources

Deorphanization of G-Protein-Coupled Receptors

2007
G-protein-coupled receptors constitute one of the major families of drug targets. Orphan receptors, for which the ligands and function are still unknown, are an attractive set of future targets for presently unmet medical needs. Screening strategies have been developed over the years in order to identify the natural ligands of these receptors.
Parmentier, Marc, Detheux, Michel
openaire   +3 more sources

Activation of G Protein–Coupled Receptors

2007
G protein-coupled receptors (GPCRs) mediate responses to hormones and neurotransmitters, as well as the senses of sight, smell, and taste. These remarkably versatile signaling molecules respond to structurally diverse ligands. Many GPCRs couple to multiple G protein subtypes, and several have been shown to activate G protein-independent signaling ...
Brian K. Kobilka, Xavier Deupi
openaire   +3 more sources

G Protein-Coupled Receptors

2019
NOVEL LIGANDS: LIGAND SCREENING SYSTEMS AND ORPHAN RECEPTORS Measurement of Competitive and Allosteric Interactions in Radioligand Binding Studies-S. Lazareno and N.Birdsall Ligand Screening of G Protein-Coupled Receptors in Yeast-J. Hadcock and M. Pausch Ligand Screening Using Melanophore Cells: Frog Skin to Combinatorial Chemistry-J.
openaire   +2 more sources

G protein—coupled receptor kinases

Cell, 1993
G protein‐coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein‐coupled receptors (GPCRs) as their primary substrates. GRK-mediated receptor phosphorylation rapidly initiates profound impairment of receptor signaling, or desensitization.
openaire   +3 more sources

Molecular signatures of G-protein-coupled receptors

Nature, 2013
A. Venkatakrishnan, X. Deupí, G. Lebon, C. Tate, G. Schertler, G. Schertler, M. Babu   +6 more
semanticscholar   +1 more source

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

Nature, 1996
H. Daub, F. Weiss, C. Wallasch, A. Ullrich   +3 more
semanticscholar   +1 more source

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

Nature, 1999
Norbert Prenzel, Esther Zwick, H. Daub, M. Leserer, Reimar Abraham, C. Wallasch, A. Ullrich   +6 more
semanticscholar   +1 more source

[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors

, 1995
J. Ballesteros, H. Weinstein
semanticscholar   +1 more source

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

Nature, 1996
I. Dikič, G. Tokiwa, S. Lev, S. Courtneidge, J. Schlessinger   +4 more
semanticscholar   +1 more source