Results 171 to 180 of about 356,759 (248)

Faculty Opinions recommendation of Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.

, 2012
Chris Yun, Sei‐Jung Lee
openalex   +2 more sources

Covalent functionalization of G protein-coupled receptors by small molecular probes. [PDF]

RSC Chem Biol
Beerkens BLH, IJzerman AP, Heitman LH, van der Es D.   +3 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Engineering G protein-coupled receptors for stabilization. [PDF]

Protein Sci
Velloso JPL, de Sá AGC, Pires DEV, Ascher DB.   +3 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Why Are Cytomegalovirus-Encoded G-Protein-Coupled Receptors Essential for Infection but Only Variably Conserved? [PDF]

Pathogens
Fares S, Krishna BA.
europepmc   +1 more source

Multiomics integration of 16S rRNA, metagenomic, and metabolomic analyses unveils gut microbiota–metabolite interactions in Guizhi Fuling capsule‐treated chronic pelvic inflammatory disease rats

Advanced Chinese Medicine, EarlyView.
Guizhi Fuling capsule likely alleviates chronic pelvic inflammatory disease by exerting anti‐inflammatory effects, restoring TCA cycle energy metabolism, reshaping gut microbiota structure, inhibiting quorum sensing signaling, and improving polysaccharide metabolic functions.
Hongli Chen, Mengyu Qian, Zhelong Feng, Xia Gao, Ruotong Huang, Yan Xie, Liang Cao, Xialin Chen, Wei Xiao   +8 more
wiley   +1 more source

Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery. [PDF]

Nat Rev Drug Discov
Conflitti P, Lyman E, Sansom MSP, Hildebrand PW, Gutiérrez-de-Terán H, Carloni P, Ansell TB, Yuan S, Barth P, Robinson AS, Tate CG, Gloriam D, Grzesiek S, Eddy MT, Prosser S, Limongelli V.   +15 more
europepmc   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source