Results 231 to 240 of about 818,382 (379)

Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors

Nature, 2004
Weihai He, F. Miao, Daniel C.-H. Lin, R. Schwandner, Zhulun Wang, Jinhai Gao, Jin-Long Chen, H. Tian, L. Ling   +8 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors. [PDF]

Nat Commun
Nepveu-Traversy ME, Hassanzadeh M, Bruneau-Cossette L, Besserer-Offroy É, Brouillette R, Morissette S, Traboulsi H, Kirby K, Murza A, Longpré JM, Breton B, Gendron FP, Gaudreau S, Boudreault PL, Sarret P.   +14 more
europepmc   +1 more source

G protein-coupled receptor of plants and its function in signal transduction

, 2012
Shuishan Song
openalex   +1 more source

Image 1_Integrated multi-omics analysis and machine learning identify G protein-coupled receptor-related signatures for diagnosis and clinical benefits in soft tissue sarcoma.jpeg

Duo Wang (1787634), Jihao Tu (8365032), Jianfeng Liu (122580), Yuting Piao (14118642), Yiming Zhao (348349), Ying Xiong (245379), Jianing Wang (465119), Xiaotian Zheng (6287762), Bin Liu (5899)   +8 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Leveraging Targeted Protein Degradation for G Protein-Coupled Receptors: The Development of CCR2 Molecular Degraders. [PDF]

J Med Chem
Essa K, Ortiz Zacarías NV, Roth S, Xin BT, de Winter S, van der Horst C, Bleijs B, de Heiden RA, Voulgaraki R, Neubert E, Ovaa H, Danen EHJ, Mulder MPC, Moreau K, van der Es D, Heitman LH.   +15 more
europepmc   +1 more source

Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist

, 2013
Stephanie Hennen, Haibo Wang, Lucas Peters, Nicole Merten, Katharina Simon, Andreas Spinrath, Stefanie Blättermann, Rhalid Akkari, Ramona Schrage, R Schröder, Daniel Schulz, Céline Vermeiren, Katrin Zimmermann, Stefan Kehraus, Christel Drewke, Alexander Pfeifer, Gabriele M. König, Klaus Mohr, Michel Gillard, Christa E. Müller, Q. Richard Lu, Jesús Gomeza, Evi Kostenis   +22 more
openalex   +1 more source

G-Protein–Coupled Receptor Kinase 2–Mediated Desensitization of Adiponectin Receptor 1 in Failing Heart [PDF]

, 2015
Yajing Wang, Erhe Gao, Wayne Bond Lau, Yang Wang, Gaizheng Liu, Jingjing Li, Xiaoliang Wang, Yuexing Yuan, Walter J. Koch, Xinliang Ma   +9 more
openalex   +1 more source

G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

Neuroscience, 2020
P. Kofuji, A. Araque
semanticscholar   +1 more source