Results 271 to 280 of about 776,363 (406)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Therapeutic and Prognostic Potential of G Protein-Coupled Receptors in Lung Adenocarcinoma: Evidence From Transcriptome Data and In Vitro Experiments. [PDF]

Clin Respir J
Yang F, Yang J, Yang G, Zhang Y.
europepmc   +1 more source

The GRK4 Subfamily of G Protein-coupled Receptor Kinases [PDF]

, 1999
Richard T. Premont, Alexander D. Macrae, Samuel Aparício, Humphrey E. Kendall, Jeffrey E. Welch, Robert J. Lefkowitz   +5 more
openalex   +1 more source

The probable arrangement of the helices in G protein‐coupled receptors.

EMBO Journal, 1993
J. Baldwin
semanticscholar   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Engineering G protein-coupled receptors for stabilization. [PDF]

Protein Sci
Velloso JPL, de Sá AGC, Pires DEV, Ascher DB.   +3 more
europepmc   +1 more source

Regulation of the G-Protein-Coupled α-Factor Pheromone Receptor by Phosphorylation [PDF]

, 1996
Qijun Chen, James B. Konopka
openalex   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Extracellular ATP increases agonist potency and reduces latency at class B G protein-coupled receptors. [PDF]

Mol Pharmacol
Zhu S, Yuan A, Duffy T, Kim BH, Ozawa T, Dixon SJ, Chidiac P.   +6 more
europepmc   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source