Results 271 to 280 of about 818,382 (379)

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

Proceedings of the National Academy of Sciences of the United States of America, 2015
Hannah M. Stoveken, A. Hajduczok, Lei Xu, G. Tall   +3 more
semanticscholar   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors. [PDF]

Nat Commun
Chung YK, Ihling CH, Zielke L, Mathiasen S, Sinz A, Langenhan T.   +5 more
europepmc   +1 more source

Heterologous regulation of trafficking and signaling of G protein-coupled receptors: β-Arrestin-dependent interactions between neurokinin receptors

, 2002
Fabien Schmidlin, Olivier Déry, Nigel W. Bunnett, Eileen F. Grady   +3 more
openalex   +1 more source

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors

Cell, 2017
X. E. Zhou, Yuanzheng He, Parker W. de Waal, Xiang Gao, Yanyong Kang, N. Van Eps, Yanting Yin, K. Pal, Devrishi Goswami, Thomas A. White, A. Barty, Naomi R. Latorraca, H. Chapman, Wayne L Hubbell, R. Dror, Raymond C. Stevens, V. Cherezov, V. Gurevich, Patrick R. Griffin, Oliver P. Ernst, K. Melcher, H. E. Xu   +21 more
semanticscholar   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Molecular basis of proton sensing by G protein-coupled receptors. [PDF]

Cell
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbølle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A.   +12 more
europepmc   +1 more source

G-protein Coupled Receptor Kinase-Interacting Protein 1(GIT1) Regulates Endothelial Cell Function: Role in PodosomeFormation, Extracellular Matrix Degradation andMigration

, 2009
Jing Wang
openalex   +1 more source

G protein-coupled estrogen receptor activation improves contractile and diastolic functions in rat renal interlobular artery to protect against renal ischemia reperfusion injury

, 2019
Yue-Chen Chang, Ziwei Han, Yang Zhang, Ying Zhou, Ziyi Feng, Long Chen, Xuerui Li, Li Li, Jun‐Qiang Si   +8 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source