A Proposed Structure for Transmembrane Segment 7 of G Protein-Coupled Receptors Incorporating an Asn-Pro/Asp-Pro Motif [PDF]
Karel Konvička+3 more
openalex +1 more source
Identifying prognostic targets in metastatic prostate cancer beyond AR
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng+13 more
wiley +1 more source
Capillary Zone Electrophoresis-Mass Spectrometry of Intact G Protein-Coupled Receptors Enables Proteoform Profiling. [PDF]
Ives AN+5 more
europepmc +1 more source
A novel gene codes for a putative G protein‐coupled receptor with an abundant expression in brain [PDF]
Brian F. O’Dowd+9 more
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Earthing effects on mitochondrial function: ATP production and ROS generation
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley +1 more source
The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases. [PDF]
Shao Y, Mei Y, Tan Y, Yang M, Wu H.
europepmc +1 more source
A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system [PDF]
Patrick J. Donohue+5 more
openalex +1 more source
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo+4 more
wiley +1 more source
Emerging modes of regulation of neuromodulatory G protein-coupled receptors. [PDF]
Gonzalez-Hernandez AJ+2 more
europepmc +1 more source
G‐protein coupled receptor kinases as modulators of G‐protein signalling
Moritz Bünemann, Marie Thérèse Hosey
openalex +2 more sources