Results 341 to 350 of about 807,055 (385)

Orphan G protein-coupled receptors: the ongoing search for a home. [PDF]

Front Pharmacol
Jobe A, Vijayan R.
europepmc   +1 more source

Substrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors

Atkinson SJ, Negoita F, Ritchie WV, Thompson K, Sakamoto K, Thompson D, Hislop JN, Hatakeyama R.   +7 more
europepmc   +1 more source

G-protein-coupled receptors and cancer [PDF]

Nature Reviews Cancer, 2007
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously, evade the immune system, increase their blood supply ...
Robert T. Dorsam, J. Silvio Gutkind
openaire   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

This is not a G protein-coupled receptor

Trends in Pharmacological Sciences, 1993
On his canvas entitled 'La trahison des Images' ('The Perfidy of Images'), René Magritte painted a tobacco pipe in a very realistic manner and added the words: 'Ceci n'est pas une pipe' ('This is not a pipe'). In similar style, it is of prime importance to state that the first three-dimensional (3D) models of G protein-coupled receptors (GPCRs) that ...
Marcel Hibert, Susanne A. Trumpp-Kallmeyer, Jan Hoflack, Anne T. Bruinvels   +3 more
openaire   +2 more sources

G-Protein-Coupled Receptors

2008
G-Protein-coupled receptors mediate many of the hypnotic and analgesic actions of the drugs employed in anesthesia. Notably, opioid agonists represent the most successful and efficacious class of analgesic agents employed over the last century. Also, major clinical advances have been made by the study of alpha(2) adrenoceptor agonists, which possess ...
R D, Sanders, D, Brian, M, Maze
openaire   +2 more sources

G protein-coupled receptors

Current Biology, 1992
The diversity of the G protein-coupled receptor superfamily is now being realised with the molecular cloning of DNA encoding many new receptors and receptor subfamilies. The existing pharmacological definitions of receptor subtypes have been extended dramatically with identification of additional subtypes at the molecular level.
John Shine, Tiina P. Iismaa
openaire   +3 more sources

Pharmacogenetics of the G Protein-Coupled Receptors

2014
Pharmacogenetics investigates the influence of genetic variants on physiological phenotypes related to drug response and disease, while pharmacogenomics takes a genome-wide approach to advancing this knowledge. Both play an important role in identifying responders and nonresponders to medication, avoiding adverse drug reactions, and optimizing drug ...
M. D. Thompson, D. E. C. Cole, V. Capra, K. A. Siminovitch, G.E. Rovati, W. M. Burnham, B. K. Rana   +6 more
openaire   +3 more sources

G Protein-Coupled Receptor Pharmacogenetics [PDF]

, 2008
Common G protein-coupled receptor (GPCR) gene variants that encode receptor proteins with a distinct sequence may alter drug efficacy without always resulting in a disease phenotype. GPCR genetic loci harbor numerous variants, such as DNA insertions or deletions and single-nucleotide polymorphisms that alter GPCR expression and function, thereby ...
Katherine A. Siminovitch, David E. C. Cole, Miles D. Thompson   +2 more
openaire   +2 more sources

Dimerization of G-Protein-Coupled Receptors

Journal of Medicinal Chemistry, 2001
The evolutionary trace (ET) method, a data mining approach for determining significant levels of amino acid conservation, has been applied to over 700 aligned G-protein-coupled receptor (GPCR) sequences. The method predicted the occurrence of functionally important clusters of residues on the external faces of helices 5 and 6 for each family or ...
Christopher Higgs, Paul D. Scott, Robert P. Bywater, Christopher A. Reynolds, Graham J. G. Upton, Mark K. Dean, Christopher R. Snell, Richard E. Smith, Trevor John Howe   +8 more
openaire   +3 more sources

G Protein Coupled Receptors

2012
G protein coupled receptors play an important role due to physiological and pathophysiological processes and are responsible for signal transduction in the cell. Furthermore, about 30 % of drugs, present on market, address G protein coupled receptors. First, the families for classification of G protein coupled receptors are presented.
Andrea Strasser, Hans-Joachim Wittmann
openaire   +2 more sources