Results 101 to 110 of about 21,426,917 (362)

The role of inhibitory G proteins and regulators of G protein signalling in the in-vivo control of heart rate and predisposition to cardiac arrhythmias

Frontiers in Physiology, 2012
Inhibitory heterotrimeric G-proteins and the control of heart rate.The activation of cell signalling pathways involving inhibitory heterotrimeric G-proteins acts to slow the heart rate via modulation of ion channels.
Richard eAng, Aaisha eOpel, Andrew eTinker   +2 more
doaj   +1 more source

G-protein activation by a metabotropic glutamate receptor

Nature, 2021
A. B. Seven, X. Barros-Álvarez, Marine de Lapeyrière, M. Papasergi-Scott, M. J. Robertson, Chensong Zhang, Robert M Nwokonko, Yang Gao, J. Meyerowitz, J. Rocher, Dominik W. Schelshorn, B. Kobilka, J. M. Mathiesen, G. Skiniotis   +13 more
semanticscholar   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

G‐protein coupled receptor kinases as modulators of G‐protein signalling

The Journal of Physiology, 1999
G‐protein coupled receptors (GPCRs) comprise one of the largest classes of signalling molecules. A wide diversity of activating ligands induce the active conformation of GPCRs and lead to signalling via heterotrimeric G‐proteins and downstream effectors.
M. Marlene Hosey, Moritz Bünemann
openaire   +4 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A new target for G protein signaling

eLife, 2017
G protein-coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gβγ subunit to the channel.
László Csanády
doaj   +1 more source

Correlation between Amount of Aggregates Formed on Freezing of Immunoglobulin G and Protein Concentration. [PDF]

, 1969
Ulla‐Britt Hansson, Kari Miikki, Ch. Larsen, Per Halkjær Nielsen, Per‐Erik Werner, Ulf Junggren, Bo Lamm, Benny Samuelsson   +7 more
openalex   +1 more source

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids*

Journal of Biological Chemistry, 2003
GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled receptors that are tandemly encoded at a single chromosomal locus in both humans and mice.
Andrew J. Brown, S. Goldsworthy, Ashley A. Barnes, Michelle M Eilert, Lili Tcheang, D. Daniels, A. Muir, M. Wigglesworth, I. Kinghorn, N. Fraser, N. Pike, J. Strum, K. Steplewski, P. Murdock, J. Holder, F. Marshall, P. Szekeres, Shelagh Wilson, D. Ignar, S. Foord, A. Wise, S. Dowell   +21 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

Nature Communications, 2018
G protein-coupled receptors (GPCRs) activate and dissociate the G protein heterotrimer into Gα-GTP and Gβγ dimer, which facilitate distinct signalling events.
Sahil Gulati, Hui Jin, Ikuo Masuho, Tivadar Orban, Yuan Cai, Els Pardon, Kirill A. Martemyanov, Philip D. Kiser, Phoebe L. Stewart, Christopher P. Ford, Jan Steyaert, Krzysztof Palczewski   +11 more
doaj   +1 more source