Results 101 to 110 of about 5,959,864 (346)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The properties and mechanism of action of plant immunomodulators in regulation of immune response – A narrative review focusing on Curcuma longa L., Panax ginseng C. A. Meyer and Moringa oleifera Lam

Heliyon
Herbal treatments have been utilized for millennia to cure a variety of ailments. There are over 20, 000 herbal remedies available to treat cancer and other disease in humans.
Muggunna Balasubramaniam, Sarah Sapuan, Ilie Fadzilah Hashim, Nurul Izza Ismail, Amira Suriaty Yaakop, Nur Azzalia Kamaruzaman, Ana Masara Ahmad Mokhtar   +6 more
doaj   +1 more source

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

eLife, 2018
The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS. Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecule ...
Javier García-Nafría, Yang Lee, Xiaochen Bai, Byron Carpenter, Christopher G Tate   +4 more
doaj   +1 more source

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation. [PDF]

, 2017
Nipah virus is an emergent paramyxovirus that causes deadly encephalitis and respiratory infections in humans. Two glycoproteins coordinate the infection of host cells, an attachment protein (G), which binds to cell surface receptors, and a fusion (F ...
Jardetzky, Theodore S, Komives, Elizabeth A, Lamb, Robert A, Leser, George P, Liu, Shiheng, Salafsky, Joshua, Wong, Joyce JW, Young, Tracy A, Zhang, Jiayan, Zhou, Z Hong   +9 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Determinants of the voltage dependence of G protein modulation within calcium channel β subunits [PDF]

, 2008
CaVβ subunits of voltage-gated calcium channels contain two conserved domains, a src-homology-3 (SH3) domain and a guanylate kinase-like (GK) domain with an intervening HOOK domain. We have shown in a previous study that, although Gβγ-mediated inhibitory
A Hummer, A Meir, A Neely, AC Dolphin, AC Meir A Dolphin, AJ Butcher, Andriy V. Dresviannikov, Annette C. Dolphin, B Li, C Altier, C Canti, C Canti, D Bichet, D Walker, DC Bell, EA Ertel, F Bertaso, F Petegem Van, G Sandoz, GJ Stephens, GJ Stephens, J Barclay, J Leroy, Jerôme Leroy, JM Maltez, Karen M. Page, KM Page, L Berrou, L Birnbaumer, LP Jones, M Pragnell, M Waard De, MR Hanlon, MW Richards, MW Richards, N Qin, N Weiss, NL Brice, RM Cohen, SC Stotz, SX Takahashi, SX Takahashi, WA Catterall, Wendy S. Pratt, Y Opatowsky, YH Chen   +45 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Protein concentration of synovial fluid in chronic rheumatoid arthritis. Estimation of protein in the synovial fluid of chronic rheumatoid arthritis by gel filtration and paper electrophoresis [PDF]

, 1968
For the purpose to reveal the characteris6cs of the synovial fluid of the chronic rheumatoid arthritis the proteins of the synovial fluid and blood serum have been analysed by employing the methods of electrophoresis, gel filtration on Sephadex G-200 ...
Seno, Takashi
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Effects of higher dietary protein and fiber intakes at breakfast on postprandial glucose, insulin, and 24-H interstitial glucose in overweight adults [PDF]

, 2017
Dietary protein and fiber independently influence insulin-mediated glucose control. However, potential additive effects are not well-known. Men and women (n = 20; age: 26 ± 5 years; body mass index: 26.1 ± 0.2 kg/m²; mean ± standard deviation) consumed ...
Amankwaah, Akua F., Campbell, Wayne W., Chen, Ningning, McCrory, Megan A., Sayer, R. Drew, Wright, Amy J.   +5 more
core   +1 more source