Results 31 to 40 of about 21,180,380 (322)
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes
Science, 2019 Choosing a partner G protein–coupled receptors (GPCRs) bind ligands outside the cell and trigger events inside the cell by selectively binding and activating specific G proteins. The selectivity occurs even among highly related GPCRs.
S. Maeda +4 more
semanticscholar +1 more source
Electrospun Nanofibers and their Application in Tissue Repair and Engineering
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020 Introduction: Tissue engineering is the repair and replacement of damaged tissues and requires a combination of cells, growth factor and porous scaffolds.
Sareh Arjmand +3 more
doaj
Design of metalloproteins and novel protein folds using variational autoencoders [PDF]
Scientific Reports 8:16189 (2018), 2018 The design of novel proteins has many applications but remains an attritional process with success in isolated cases. Meanwhile, deep learning technologies have exploded in popularity in recent years and are increasingly applicable to biology due to the rise in available data.
arxiv +1 more source
Scientific Reports, 2018 CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex.
Gundeep Kaur +5 more
doaj +1 more source
Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells
Journal of Biological Chemistry, 2018 G protein–coupled receptors (GPCRs) are key signaling proteins that regulate nearly every aspect of cell function. Studies of GPCRs have benefited greatly from the development of molecular tools to monitor receptor activation and downstream signaling ...
Qingwen Wan +6 more
semanticscholar +1 more source
A G-protein pathway determines grain size in rice
Nature Communications, 2018 Manipulating grain size is an effective strategy for increasing cereal yields. Here we identify a pathway composed of five subunits of the heterotrimeric G proteins that regulate grain length in rice.
Shengyuan Sun +7 more
semanticscholar +1 more source
Heterotrimeric G-Protein Signalers and RGSs in Aspergillus fumigatus
Pathogens, 2020 The heterotrimeric G-protein (G-protein) signaling pathway is one of the most important signaling pathways that transmit external signals into the inside of the cell, triggering appropriate biological responses. The external signals are sensed by various
Hee-Soo Park +3 more
doaj +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors
British Journal of Pharmacology, 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
Stephen P. H. Alexander +11 more
semanticscholar +1 more source
The Disruption of a Gα Subunit Sheds New Light on the Pathogenicity of Stagonospora nodorum on Wheat
Molecular Plant-Microbe Interactions, 2004 Gna1, a gene encoding a Gα subunit, a key component of signal transduction pathways, has been cloned and characterized in the wheat pathogen Stagonospora nodorum.
Peter S. Solomon +4 more
doaj +1 more source
Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer‐Based Protein Engineering
Advanced Science, 2020 Organophosphate nerve agents rapidly inhibit cholinesterases thereby destroying the ability to sustain life. Strong nucleophiles, such as oximes, have been used as therapeutic reactivators of cholinesterase‐organophosphate complexes, but suffer from ...
Libin Zhang +7 more
doaj +1 more source