Results 31 to 40 of about 21,426,917 (362)

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

eLife, 2022
Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo, Eojin Yoon, Ye-Eun Jeon, Ji-Hye Yun, Naito Ishimoto, Hyeonuk Woo, Sam-Yong Park, Ji-Joon Song, Weontae Lee   +8 more
doaj   +1 more source

Transforming G proteins [PDF]

Oncogene, 2001
Heterotrimeric guanine nucleotide binding proteins, commonly known as G proteins form a super-family of signal transduction proteins. They are peripherally associated with the plasma membrane and provide signal coupling to seven transmembrane surface receptors. G proteins are composed of monomers of alpha, beta, and gamma subunits.
N. Dhanasekaran, V. Radhika
openaire   +2 more sources

ARTD10/PARP10 Induces ADP-Ribosylation of GAPDH and Recruits GAPDH into Cytosolic Membrane-Free Cell Bodies When Overexpressed in Mammalian Cells

Challenges, 2018
Protein ADP-ribosylation is a reversible post-translational modification of cellular proteins that is catalysed by enzymes that transfer one (mono) or several (poly) units of ADP-ribose from β-NAD+ to a specific amino acid of the target protein. The
Emilia Mayo, Gaia Fabrizio, Emanuele Salvatore Scarpa, Annalisa Stilla, Nadia Dani, Fulvio Chiacchiera, Henning Kleine, Francesca Attanasio, Bernhard Lüscher, Maria Di Girolamo   +9 more
doaj   +1 more source

The Molecular Basis of G Protein-Coupled Receptor Activation.

Annual Review of Biochemistry, 2018
G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. Upon activation by a ligand, the receptor binds to a partner heterotrimeric G protein and promotes exchange of GTP for GDP, leading to dissociation of the
W. Weis, B. Kobilka
semanticscholar   +1 more source

Isolation and Taxonomic Characterization of Novel Haloarchaeal Isolates From Indian Solar Saltern: A Brief Review on Distribution of Bacteriorhodopsins and V-Type ATPases in Haloarchaea

Frontiers in Microbiology, 2020
Haloarchaea inhabit high salinity environments worldwide. They are a potentially rich source of crucial biomolecules like carotenoids and industrially useful proteins.
Dipesh Kumar Verma, Chetna Chaudhary, Latika Singh, Chandni Sidhu, Busi Siddhardha, Senthil E. Prasad, Krishan Gopal Thakur   +6 more
doaj   +1 more source

Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein

MedComm, 2022
GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear ...
Fang Ye, Thian‐Sze Wong, Geng Chen, Zhiyi Zhang, Binghao Zhang, Shiyi Gan, Wei Gao, Jiancheng Li, Zhangsong Wu, Xin Pan, Yang Du   +10 more
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

British Journal of Pharmacology, 2019
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where ...
Stephen P. H. Alexander, A. Christopoulos, A. Davenport, E. Kelly, A. Mathie, J. A. Peters, E. Veale, J. Armstrong, E. Faccenda, S. Harding, Adam J Pawson, J. Sharman, C. Southan, J. Davies   +13 more
semanticscholar   +1 more source

Binding characteristics of staphylococcal protein A and streptococcal protein G for fragment crystallizable portion of human immunoglobulin G

Computational and Structural Biotechnology Journal, 2021
In the wide array of physiological processes, protein–protein interactions and their binding are the most basal activities for achieving adequate biological metabolism.
Hae Gon Lee, Shinill Kang, Joon Sang Lee
doaj   +1 more source

GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species

Vascular Biology, 2019
The discovery and extension of G-protein-coupled receptor (GPCR) transactivation-dependent signalling has enormously broadened the GPCR signalling paradigm.
Raafat Mohamed, Reearna Janke, Wanru Guo, Yingnan Cao, Ying Zhou, Wenhua Zheng, Hossein Babaahmadi-Rezaei, Suowen Xu, Danielle Kamato, Peter J Little   +9 more
doaj   +1 more source

REGA-SIGN: Development of a Novel Set of NanoBRET-Based G Protein Biosensors

Biosensors, 2023
Despite G protein-coupled receptors (GPCRs) being important theapeutic targets, the signaling properties of many GPCRs remain poorly characterized. GPCR activation primarily initiates heterotrimeric G protein signaling. To detect ligand-induced G protein
Katrijn Boon, Nathan Vanalken, Eef Meyen, Dominique Schols, Tom Van Loy   +4 more
doaj   +1 more source