THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where ...
Stephen P. H. Alexander+13 more
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Human metapneumovirus (HMPV) is a major pediatric respiratory pathogen with currently no specific treatment or licensed vaccine. Different strategies to prevent this infection have been evaluated, including live-attenuated vaccines (LAV) based on SH and ...
Julia Dubois+16 more
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G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding [PDF]
Evi Kostenis+2 more
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Dual positive and negative regulation of GPCR signaling by GTP hydrolysis [PDF]
G protein-coupled receptors (GPCRs) regulate a variety of intracellular pathways through their ability to promote the binding of GTP to heterotrimeric G proteins. Regulator of G protein signaling (RGS) proteins increase the intrinsic GTPase activity of G-
Berg, Hugo van den+8 more
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REGA-SIGN: Development of a Novel Set of NanoBRET-Based G Protein Biosensors
Despite G protein-coupled receptors (GPCRs) being important theapeutic targets, the signaling properties of many GPCRs remain poorly characterized. GPCR activation primarily initiates heterotrimeric G protein signaling. To detect ligand-induced G protein
Katrijn Boon+4 more
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Modules in the photoreceptor RGS9-1•Gβ5L GTPase-accelerating protein complex control effector coupling, GTPase acceleration, protein folding, and stability [PDF]
RGS (regulators of G protein signaling proteins regulate G protein signaling by accelerating GTP hydrolysis, but little is known about regulation of GTPase-accelerating protein (GAP) activities or roles of domains and subunits outside the catalytic cores.
Chen, Ching-Kang+8 more
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Protein ADP-ribosylation is a reversible post-translational modification of cellular proteins that is catalysed by enzymes that transfer one (mono) or several (poly) units of ADP-ribose from β-NAD+ to a specific amino acid of the target protein. The
Emilia Mayo+9 more
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Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast
The yeast Saccharomyces cerevisiae has long been used to produce alcohol from glucose and other sugars. While much is known about glucose metabolism, relatively little is known about the receptors and signaling pathways that indicate glucose availability.
Shuang Li+7 more
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Determination of Energy and Protein Requirements of Sheep in Indonesia Using a Meta-analytical Approach [PDF]
The objective of this study was to determine energy and protein requirements, for both maintenance and gain, of sheep in Indonesia by using a meta-analysis method.
Astuti, D. A. (D)+5 more
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MAPKs in development: insights from Dictyostelium signaling pathways
Mitogen activated protein kinases (MAPKs) play important roles in the development of eukaryotic organisms through the regulation of signal transduction pathways stimulated by external signals.
Hadwiger Jeffrey A., Nguyen Hoai-Nghia
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