Results 41 to 50 of about 21,180,380 (322)
DEER Analysis of GPCR Conformational Heterogeneity
Biomolecules, 2021 G protein-coupled receptors (GPCRs) represent a large class of transmembrane helical proteins which are involved in numerous physiological signaling pathways and therefore represent crucial pharmacological targets.
Matthias Elgeti, Wayne L. Hubbell
doaj +1 more source
Sequence co-evolution gives 3D contacts and structures of protein complexes [PDF]
, 2014 Protein-protein interactions are fundamental to many biological processes. Experimental screens have identified tens of thousands of interactions and structural biology has provided detailed functional insight for select 3D protein complexes. An alternative rich source of information about protein interactions is the evolutionary sequence record ...
arxiv +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Cryo-EM structure of the activated GLP-1 receptor in complex with G protein
Nature, 2017 Glucagon-like peptide 1 (GLP-1) is a hormone with essential roles in regulating insulin secretion, carbohydrate metabolism and appetite. GLP-1 effects are mediated through binding to the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR)
Yan Zhang +10 more
semanticscholar +1 more source
Diabetıc Cardiomyopathy And G Protein
Van Tıp Dergisi, 2019 Diabetes mellitus (DM) is one of the most important disease in the modern society and represents not only a medical but also social problem. Cardiovascular disease is the primary cause of death in people with either type 1 or type 2 diabetes.
Yasemin Behram Kandemir +3 more
doaj +1 more source
Heterotrimeric G Protein Signaling in Abiotic Stress
Plants, 2022 As sessile organisms, plants exhibit extraordinary plasticity and have evolved sophisticated mechanisms to adapt and mitigate the adverse effects of environmental fluctuations. Heterotrimeric G proteins (G proteins), composed of α, β, and γ subunits, are
Yijie Wang, Jose Ramón Botella
doaj +1 more source
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
Structure of an Endosomal Signaling GPCR–G Protein–β-arrestin Mega-Complex
Nature Structural & Molecular Biology, 2019 Classically, G-protein-coupled receptors (GPCRs) are thought to activate G protein from the plasma membrane and are subsequently desensitized by β-arrestin (β-arr).
Anthony H. Nguyen +23 more
semanticscholar +1 more source
A statistical mechanics investigation of Unfolded Protein Response across organisms [PDF]
Scientific Reports, 14, 2024, 27658Living systems rely on coordinated molecular interactions, especially those related to gene expression and protein activity. The Unfolded Protein Response is a crucial mechanism in eukaryotic cells, activated when unfolded proteins exceed a critical threshold.
arxiv +1 more source
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source