Results 41 to 50 of about 5,910,464 (346)

Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast

Biomolecules, 2022
The yeast Saccharomyces cerevisiae has long been used to produce alcohol from glucose and other sugars. While much is known about glucose metabolism, relatively little is known about the receptors and signaling pathways that indicate glucose availability.
Shuang Li, Yuanyuan Li, Blake R. Rushing, Sarah E. Harris, Susan L. McRitchie, Daniel Dominguez, Susan J. Sumner, Henrik G. Dohlman   +7 more
doaj   +1 more source

Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses [PDF]

, 2011
Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits.
Chang, Chun Yun, Crawford, Devon C, Hyrc, Krzysztof L, Mennerick, Steven   +3 more
core   +2 more sources

On the hierarchical classification of G Protein-Coupled Receptors [PDF]

, 2007
Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
A. A. Freitas, A. Secker, Attwood, Bhasin, Bhasin, Bissantz, Cardoso, Christopoulos, D. R. Flower, Das, Davies, Flower, Flower, Foord, Gether, Gloriam, Guo, Horn, H  bert, J. Timmis, Karchin, Keerthi, Klabunde, Kolakowski, Lapinsh, M. Mendao, M. N. Davies, Milligan, Papasaikas, Prabhu, Sandberg, Schi  th   +31 more
core   +2 more sources

Electrospun Nanofibers and their Application in Tissue Repair and Engineering

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020
Introduction: Tissue engineering is the repair and replacement of damaged tissues and requires a combination of cells, growth factor and porous scaffolds.
Sareh Arjmand, Alireza Partovi Baghdadeh, Amin Hamidi, Seyed Omid Ranaei Siadat   +3 more
doaj  

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. [PDF]

, 2015
G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-protein-independent pathways.
Barty, Anton, Basu, Shibom, Boutet, Sébastien, Caffrey, Martin, Caro, Lydia N, Carragher, Bridget, Chapman, Henry N, Cherezov, Vadim, Coe, Jesse, Conrad, Chelsie E, de Waal, Parker W, Diederichs, Kay, Dong, Yuhui, Ernst, Oliver P, Fromme, Petra, Fromme, Raimund, Gao, Xiang, Gati, Cornelius, Griffin, Patrick R, Grotjohann, Ingo, Gu, Xin, Gurevich, Vsevolod V, Han, Gye Won, He, Yuanzheng, Howe, Nicole, Hubbell, Wayne L, Ishchenko, Andrii, James, Daniel, Jiang, Hualiang, Jiang, Yi, Kang, Yanyong, Katritch, Vsevolod, Ke, Jiyuan, Kupitz, Christopher, Lee, Regina J, Li, Dianfan, Li, Jun, Lisova, Stella, Liu, Haiguang, Liu, Wei, Ma, Jinming, Melcher, Karsten, Messerschmidt, Marc, Moeller, Arne, Pal, Kuntal, Pascal, Bruce D, Potter, Clinton S, Roy-Chowdhury, Shatabdi, Spence, John CH, Standfuss, Jörg, Stevens, Raymond C, Suino-Powell, Kelly M, Tan, MH Eileen, Tan, Minjia, Van Eps, Ned, Vishnivetskiy, Sergey A, Wang, Dingjie, Wang, Meitian, Weierstall, Uwe, West, Graham M, White, Thomas A, Williams, Garth J, Xu, H Eric, Xu, Qingping, Yang, Huaiyu, Yefanov, Oleksandr, Zatsepin, Nadia A, Zhang, Chenghai, Zhao, Yingming, Zheng, Zhong, Zhi, Xiaoyong, Zhou, X Edward   +71 more
core   +1 more source

G Protein Trafficking [PDF]

, 2012
The classical view of heterotrimeric G protein signaling places G -proteins at the cytoplasmic surface of the cell's plasma membrane where they are activated by an appropriate G protein-coupled receptor. Once activated, the GTP-bound Gα and the free Gβγ are able to regulate plasma membrane-localized effectors, such as adenylyl cyclase, phospholipase C ...
openaire   +2 more sources

Sources of dietary protein and risk of hypertension in a general Dutch population [PDF]

, 2012
Evidence suggests a small beneficial effect of dietary protein on blood pressure (BP), especially for plant protein. We examined the relationship between several types of dietary protein (total, plant, animal, dairy, meat and grain) and the risk of ...
Altorf-van der Kuil, W., Boer, J.M.A., Engberink, M.F., Geleijnse, J.M., Verschuren, W.M.M.   +4 more
core   +2 more sources

The G protein γ subunit SlGGC1 regulates saline-alkali stress response in tomato

Vegetable Research
Saline-alkali stress poses a severe threat to crop yield and quality. While significant progress has been achieved in elucidating the mechanisms of plant resistance to salt stress, the molecular underpinnings governing plant responses to saline-alkali ...
Yanru Zhang, Jian Liu, Heyao Sun, Yinqiang Zang, Yu Zhang, Hui Wang, Chuanlong Sun, Xianwen Meng, Lei Deng, Qian Chen, Chuanyou Li   +10 more
doaj   +1 more source

Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

Scientific Reports, 2018
CarD is an essential global transcription regulator from Mycobacterium tuberculosis (Mtb) that binds RNA polymerase and activates transcription by stabilizing the transcription initiation complex.
Gundeep Kaur, Soni Kaundal, Srajan Kapoor, Jonathan M. Grimes, Juha T. Huiskonen, Krishan Gopal Thakur   +5 more
doaj   +1 more source

A Non-Covalent Antibody Complex for the Delivery of anti-cancer drugs [PDF]

, 2019
Antibody drug conjugates (ADCs), which are obtained by coupling a potent cytotoxic agent to a monoclonal antibody (mAb), are traditionally bound in a random way to lysine or cysteine residues, with the final product's heterogeneity having an important ...
Grigoletto, Antonella, Maso, Katia, Monia Montagner, Isabella, Pasut, Gianfranco, Rosato, Antonio, Schiavon, Oddone   +5 more
core   +1 more source