Results 261 to 270 of about 105,256 (293)
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GABA-A-Receptor Ligands of Flavonoid Structure
Current Topics in Medicinal Chemistry, 2002This review describes the new research developments that have established the CNS-activity of some natural flavonoids. The properties of flavone, chrysin, apigenin and cirsiliol are described and a survey of the occurrence of ligands for the benzodiazepine binding site in the flavonoid field is attempted.
Mariel, Marder, Alejandro C, Paladini
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GABA-A Receptor Ligands and their Therapeutic Potentials
Current Topics in Medicinal Chemistry, 2002The GABA(A) receptor system is implicated in a number of neurological diseases, making GABA(A) receptor ligands interesting as potential therapeutic agents. Only a few different classes of structures are currently known as ligands for the GABA recognition site on the GABA(A) receptor complex, reflecting the very strict structural requirements for GABA ...
Frølund, Bente +4 more
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GABAA receptor epilepsy mutations
Biochemical Pharmacology, 2004Idiopathic generalized epilepsy (IGE) syndromes are diseases that are characterized by absence, myoclonic, and/or primary generalized tonic-clonic seizures in the absence of structural brain abnormalities. Although it was long hypothesized that IGE had a genetic basis, only recently have causative genes been identified.
Robert L, Macdonald +3 more
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GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton
Nature, 1999Type-A receptors for the neurotransmitter GABA (gamma-aminobutyric acid) are ligand-gated chloride channels that mediate inhibitory neurotransmission. Each subunit of the pentameric receptor protein has ligand-binding sites in the amino-terminal extracellular domain and four membrane-spanning regions, one of which forms a wall of the ion channel.
H, Wang +4 more
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GABA-A receptor subtypes, benzodiazepines and feeding
Appetite, 2008Benzodiazepines (BZs) enhance food intake by acting at GABAA receptors which have a pentameric structure consisting of two a, two s and one γ2 subunit. a1, a2, a3, and a5 containing GABAA receptors are sensitive to BZs such as diazepam and midazolam. Cooper (2005) suggested that the effects of BZs on feeding were mediated by a2 or a3 containing GABAA ...
H.V. Morris, D.N. Stephens, P.G. Clifton
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Supersensitivity of GABA-A receptors in hepatic encephalopathy
Neurochemical Research, 1990During the past decade a new approach to pathogenetic studies of hepatic encephalopathy has been undertaken to identify the neurochemical alterations which characterize the syndrome. Using animal models of hepatic encephalopathy electrophysiological, behavioral, pharmacological and biochemical evidence were provided of an increased functional activity ...
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[GABA(A) receptor trafficking and epilepsy].
Nihon rinsho. Japanese journal of clinical medicine, 2014Recent studies clarified a dynamic regulation of the intracellular trafficking of GABA(A) receptors and its involvement in the pathophysiology of epilepsy. GABA(A) synaptic inhibition decreased in the hippocampal CA1 area of patients with intractable temporal lobe epilepsy (TLE).
Eiichi, Maru, Hiroyuki, Ura
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Interaction of Steroids with the GABA-A Receptor
Current Topics in Medicinal Chemistry, 2002Over the last two decades there has been a resurgence of interest in steroids as potential therapeutics for central nervous system disorders. This interest followed the discovery that neurosteroids and neuroactive steroids are potent modulators of GABA(A) receptor function.
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GABAA Receptor Channel Pharmacology
Current Pharmaceutical Design, 2005GABA(A) receptor channels are ubiquitous in the mammalian central nervous system mediating fast inhibitory neurotransmission by becoming permeant to chloride ions in response to GABA. The emphasis of this review is on the rich chemical diversity of ligands that influence GABA(A) receptor function. Such diversity provides many avenues for the design and
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Editing modifies the GABA(A) receptor subunit alpha3.
RNA (New York, N.Y.), 2007Adenosine to inosine (A-to-I) pre-mRNA editing by the ADAR enzyme family has the potential to increase the variety of the proteome. This editing by adenosine deamination is essential in mammals for a functional brain. To detect novel substrates for A-to-I editing we have used an experimental method to find selectively edited sites and combined it with ...
Ohlson, Johan +3 more
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