Results 31 to 40 of about 114,819,381 (306)

Effects of ethylenediamine – a putative GABA-releasing agent – on rat hippocampal slices and neocortical activity in vivo [PDF]

, 2010
The simple diamine diaminoethane (ethylenediamine, EDA) has been shown to activate GABA receptors in the central and peripheral nervous systems, partly by a direct action and partly by releasing endogenous GABA.
Lui, C., Stone, T.W., Addae, J.I., Trevor W. Stone, Caleb Lui, Jonas I. Addae   +5 more
core   +1 more source

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA

Frontiers in Cellular Neuroscience, 2015
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer   +8 more
doaj   +1 more source

Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. [PDF]

PLoS ONE, 2012
In neuronal cells the intracellular trafficking machinery controls the availability of neurotransmitter receptors at the plasma membrane, which is a critical determinant of synaptic strength.
Viviana Valdés, José Ignacio Valenzuela, Daniela A Salas, Matías Jaureguiberry-Bravo, Carolina Otero, Christina Thiede, Christoph F Schmidt, Andrés Couve   +7 more
doaj   +1 more source

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents [PDF]

, 2013
Activation of GABAA receptors (GABAARs) produces two forms of inhibition: ‘phasic’ inhibition generated by the rapid, transient activation of synaptic GABAARs by presynaptic GABA release, and tonic inhibition generated by the persistent activation of ...
Herd, Murray B, Belelli, D., Wlodarczyk, A. I., Sylantyev, S., Linthorst, Astrid C.E., Walker, Matthew C., Walker, M. C., Rusakov, Dmitri A, Lambert, Jeremy J, Wlodarczyk, Agnieszka I., Kersanté, Flavie, Walker, Matthew C, Semyanov, A., Semyanov, Alexey, Rusakov, Dmitri A., Rusakov, D. A., Herd, Murray B., Linthorst, A. C. E., Lambert, Jeremy J., Pavlov, I., Linthorst, Astrid C E, Lambert, J. J., Herd, M. B., Kersante, F., Wlodarczyk, Agnieszka I, Pavlov, Ivan, Sylantyev, Sergiy, Belelli, Delia   +27 more
core   +1 more source

The Mechanism of Enantioselective Neurosteroid Actions on GABA_A Receptors

Biomolecules, 2023
The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABAA receptors. Interestingly, the PAM effects of ALLO are strongly enantioselective, whereas those of PREG are not.
Hiroki Tateiwa, Satyanarayana M. Chintala, Ziwei Chen, Lei Wang, Fatima Amtashar, John Bracamontes, Allison L. Germann, Spencer R. Pierce, Douglas F. Covey, Gustav Akk, Alex S. Evers   +10 more
doaj   +1 more source

Actions of Agonists, Fipronil and Ivermectin on the Predominant In Vivo Splice and Edit Variant (RDLbd, I/V) of the Drosophila GABA Receptor Expressed in Xenopus laevis Oocytes [PDF]

, 2014
Ionotropic GABA receptors are the targets for several classes of insecticides. One of the most widely-studied insect GABA receptors is RDL (resistance to dieldrin), originally isolated from Drosophila melanogaster.
Philip Biggin, Suwanmanee, S, Musgaard, M, David Sattelle, Steven David Buckingham, Lees, K, Sattelle, D, Maria Musgaard, Siros Suwanmanee, Kristin Lees, Buckingham, SD, Biggin, P   +11 more
core   +2 more sources

Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity. [PDF]

, 2015
GABA transporters control extracellular GABA, which regulates the key aspects of neuronal and network behaviour. A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA ...
Rusakov, Dmitri A., Walker, MC, Savtchenko, L, Pavlov, I, Megalogeni, M, Walker, Matthew C., Rusakov, DA, Savtchenko, Leonid, Pavlov, Ivan, Megalogeni, Maria   +9 more
core   +1 more source

Post-synaptic GABAA receptors potentiate transmission by recruiting CaV2 channels to their inputs

Cell Reports, 2023
Summary: We describe a retrograde synaptic signal at the C. elegans GABAergic neuromuscular junction. At this synapse, GABA release is controlled by two voltage-activated calcium channels (UNC-2/CaV2 and EGL-19/CaV1), and muscle responses are mediated by
Jian Zhao, Luna Gao, Stephen Nurrish, Joshua M. Kaplan   +3 more
doaj   +1 more source

Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism. [PDF]

PLoS ONE, 2016
The loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of ρ1 GABAC receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative partial agonists and antagonists. Thr244 has
Moawiah M Naffaa, Nathan Absalom, V Raja Solomon, Mary Chebib, David E Hibbs, Jane R Hanrahan   +5 more
doaj   +1 more source

Anaesthetic impairment of immune function is mediated via GABA(A) receptors.

PLoS ONE, 2011
BackgroundGABA(A) receptors are members of the Cys-loop family of neurotransmitter receptors, proteins which are responsible for fast synaptic transmission, and are the site of action of wide range of drugs.
Daniel W Wheeler, Andrew J Thompson, Federico Corletto, Jill Reckless, Justin C T Loke, Nicolas Lapaque, Andrew J Grant, Pietro Mastroeni, David J Grainger, Claire L Padgett, John A O'Brien, Nigel G A Miller, John Trowsdale, Sarah C R Lummis, David K Menon, John S Beech   +15 more
doaj   +1 more source