Results 11 to 20 of about 449,429 (310)

Conditional gene deletion reveals functional redundancy of GABA_B receptors in peripheral nociceptors in vivo

Molecular Pain, 2009
Background γ-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bettler Bernhard, Tegeder Imgard, Brugger Stefan, Agarwal Nitin, Gangadharan Vijayan, Kuner Rohini, Kurejova Martina   +6 more
doaj   +2 more sources

Characterization of GABA Receptors [PDF]

Current Protocols in Pharmacology, 1998
AbstractDescribed in this unit are ligand‐binding assays for GABAA, GABAB, and the homomeric ρ GABAA(formerly GABAC) receptor recognition sites in brain tissue. Although GABA binding sites are present in peripheral organs, most research is directed toward examining these receptors in the CNS.
S J, Enna, Kenneth E, McCarson
openaire   +2 more sources

Evidence for a GABAergic system in rodent and human testis: Local GABA production and GABA receptors [PDF]

, 2003
The major neurotransmitter of the central nervous system, gamma-aminobutyric acid (GABA), exerts its actions through GABA(A), GABA(B) and GABA(C) receptors.
Doepner, Richard F. G., Frungieri, Monica Beatriz, Kohn, Frank M., Doepner, R., Gamel-Didelon, Katia, Geigerseder, C., Mayerhofer, Artur, Thalhammer, A,, Geigerseder, Christof, Frungieri, Monica B., Köh, F. M., Calandra, Ricardo Saul, Calandra, Ricardo S., Gamel Didelon, K., Thalhammer, Andrea   +14 more
core   +1 more source

Computational prediction of MicroRNAs targeting GABA receptors and experimental verification of miR-181, miR-216 and miR-203 targets in GABA-A receptor

BMC Research Notes, 2012
Background GABA receptors are well known as the inhibitory receptors in the central nervous system and are also found in peripheral tissues. We have previously shown that GABA receptors are involved in lung development and fluid homeostasis. However, the
Zhao Chunling, Huang Chaoqun, Weng Tingting, Xiao Xiao, Ma Hong, Liu Lin   +5 more
doaj   +1 more source

An autocrine role for pituitary GABA: Activation of GABA-B receptors and regulation of growth hormone levels [PDF]

, 2002
There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs.
Corsi, C., Pepeu, G., Gratzl, M., Gamel-Didelon, Katia, Jung, H., Mayerhofer, Artur   +5 more
core   +1 more source

GABA_A-ρ Receptors in the CNS: Their Functional, Pharmacological, and Structural Properties in Neurons and Astroglia

Neuroglia, 2023
Gamma-aminobutyric acid (GABA) is known as the main inhibitory transmitter in the central nervous system (CNS), where it hyperpolarizes mature neurons through activation of GABAA receptors, pentameric complexes assembled by combination of subunits (α1–6,
Abraham Rosas-Arellano, Argel Estrada-Mondragón, Ataúlfo Martínez-Torres, Daniel Reyes-Haro   +3 more
doaj   +1 more source

GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.

PLoS ONE, 2012
GABA is more than the main inhibitory neurotransmitter found in the adult CNS. Several studies have shown that GABA regulates the proliferation of progenitor and stem cells.
Henrik Ring, Suresh Kumar Mendu, Shahrzad Shirazi-Fard, Bryndis Birnir, Finn Hallböök   +4 more
doaj   +1 more source

Effects of ethylenediamine – a putative GABA-releasing agent – on rat hippocampal slices and neocortical activity in vivo [PDF]

, 2010
The simple diamine diaminoethane (ethylenediamine, EDA) has been shown to activate GABA receptors in the central and peripheral nervous systems, partly by a direct action and partly by releasing endogenous GABA.
Lui, C., Stone, T.W., Addae, J.I.
core   +1 more source

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA

Frontiers in Cellular Neuroscience, 2015
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer   +8 more
doaj   +1 more source

Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors

Brazilian Journal of Medical and Biological Research, 2001
The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the ...
C.M. Yokoro, S.M.S. Pesquero, R.M.M. Turchetti-Maia, J.N. Francischi, M.A.K.F. Tatsuo   +4 more
doaj   +1 more source