Results 51 to 60 of about 176,537 (302)

General Anesthetic Actions on GABAA Receptors [PDF]

Current Neuropharmacology, 2010
General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABA(A) receptor.
Garcia, Paul S, Kolesky, Scott E, Jenkins, Andrew   +2 more
openaire   +2 more sources

Understanding the function of the GABAergic system and its potential role in rheumatoid arthritis

Frontiers in Immunology, 2023
Rheumatoid arthritis (RA) is a highly disabling chronic autoimmune disease. Multiple factors contribute to the complex pathological process of RA, in which an abnormal autoimmune response, high survival of inflammatory cells, and excessive release of ...
Yu Shan, Yu Shan, Yu Shan, Jianan Zhao, Jianan Zhao, Jianan Zhao, Yixin Zheng, Yixin Zheng, Yixin Zheng, Shicheng Guo, Shicheng Guo, Steven J. Schrodi, Steven J. Schrodi, Dongyi He, Dongyi He, Dongyi He, Dongyi He   +16 more
doaj   +1 more source

Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro [PDF]

, 1980
Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion.
A Nistri, A Tokunaga, B Hue, B Katz, C Nicholson, CL Schauf, DA Brown, DA Brown, DA Brown, DA Brown, DA McAfee, DI Wallis, E Jankowska, E Kato, E Kato, G. ten Bruggencate, H Lundh, H Lundh, H Meves, IG Marshall, JE Heuser, JZ Yeh, JZ Yeh, K Golenhofen, M Lemeignan, M Lemeignan, M. Galvan, NG Bowery, P. Grafe, PR Adams, R Llinás, SY Chiu, T Brismar, T Yanagisawa, W Ulbricht, WC Bowman, WW Douglas   +36 more
core   +1 more source

Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes. [PDF]

PLoS ONE, 2012
γ-Aminobutyric acid (GABA) is the most prominent neuroinhibitory transmitter in the brain, where it activates neuronal GABA-A receptors (GABA-A channels) located at synapses and outside of synapses.
Suresh K Mendu, Amol Bhandage, Zhe Jin, Bryndis Birnir   +3 more
doaj   +1 more source

Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor [PDF]

, 2011
Cys-loop receptor binding sites characteristically possess an "aromatic box," where several aromatic amino acid residues surround the bound ligand. A cation-π interaction between one of these residues and the natural agonist is common, although the ...
Ashby, Jamie A., Dougherty, Dennis A., Lummis, Sarah C. R., McGonigle, Ian   +3 more
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Electrophysiological receptor mapping of GABA-A receptors

, 2020
The non-invasive study of cortical oscillations provides a window onto neuronal processing. Temporal correlation of these oscillations between distinct anatomical regions is considered a marker of functional connectedness. As the most abundant inhibitory neurotransmitter in the mammalian brain, γ-aminobutyric acid (GABA) is thought to play a crucial ...
Shaw, Alexander D, Chandler, Hannah L, Hamandi, Khalid, Muthukumaraswamy, Suresh D, Hammers, Alexander, Singh, Krish D   +5 more
openaire   +1 more source

Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]

, 2017
A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa, Kaufman, Daniel L, Middleton, Blake, Tian, Jide   +3 more
core   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Experimental GABA A Receptor Agonists and Allosteric Modulators for the Treatment of Focal Epilepsy

Journal of Experimental Pharmacology, 2021
Slobodan M Janković,1 Miralem Dješević,2 Snežana V Janković1 1Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 2Cardiology Department, Private Policlinic Center Eurofarm, Sarajevo, Bosnia and HercegovinaCorrespondence ...
Janković SM, Dješević M, Janković SV
doaj