Results 81 to 90 of about 105,256 (293)

Fast detection of extrasynaptic GABA with a whole-cell sniffer

Frontiers in Cellular Neuroscience, 2014
Gamma-amino-butyric acid (GABA) is the main inhibitory transmitter of the brain. It operates by binding to specific receptors located both inside and outside synapses.
Rasmus Kordt Christensen, Anders Victor Petersen, Nicole eSchmitt, Jean-François ePerrier   +3 more
doaj   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Structure-Dependent Activity of Natural GABA(A) Receptor Modulators [PDF]

Molecules, 2018
GABA(A) receptors are ligand-gated ion channels consisting of five subunits from eight subfamilies, each assembled in four hydrophobic transmembrane domains. This pentameric structure not only allows different receptor binding sites, but also various types of ligands, such as orthosteric agonists and antagonists, positive and negative allosteric ...
openaire   +3 more sources

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Neurally Released GABA Acts via GABAC Receptors to Modulate Ca2+ Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum

Frontiers in Physiology, 2018
γ-Aminobutyric Acid (GABA) and its receptors, GABAA,B,C, are expressed in several locations along the gastrointestinal tract. Nevertheless, a role for GABA in enteric synaptic transmission remains elusive.
Katerina Koussoulas, Mathusi Swaminathan, Candice Fung, Joel C. Bornstein, Jaime P. P. Foong   +4 more
doaj   +1 more source

The Antiepileptic Drug Levetiracetam Stabilizes the Human Epileptic GABA_A Receptors upon Repetitive Activation [PDF]

, 2007
Eleonora Palma, Davide Ragozzino, Silvia Di Angelantonio, Addolorata Mascia, Francesca Maiolino, M. Manfredi, Giampaolo Cantore, Vincenzo Esposito, Giancarlo Di Gennaro, P. P. Quarato, Ricardo Miledi, Fabrizio Eusebi   +11 more
openalex   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Genetic Downregulation of GABA_B Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord

Cells
GABAergic signaling and GABAB receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination.
Davide Gobbo, Phillip Rieder, Li-Pao Fang, Emeline Buttigieg, Moritz Schablowski, Elisa Damo, Nathalie Bosche, Eleonora Dallorto, Pascal May, Xianshu Bai, Frank Kirchhoff, Anja Scheller   +11 more
doaj   +1 more source

Sushi domains confer distinct trafficking profiles on GABA _B receptors [PDF]

, 2012
Saad Hannan, Megan E. Wilkins, Trevor G. Smart   +2 more
openalex   +1 more source

The differential effects of chronically administered GABA-A receptor ligands on recombinant GABA-A receptor expression

Periodicum biologorum, 2010
The main inhibitory neurotransmitter in the mammalian brain, gamma-aminobutyric acid (GABA), fulfils most of its physiological actions via GABA-A receptors. GABA-A receptors possess binding sites for a variety of different drugs, including clinically relevant benzodiazepines, barbiturates, general anesthetics and neurosteroides.
Peričić, Danka, Švob Štrac, Dubravka, Jazvinšćak Jembrek, Maja   +2 more
openaire   +1 more source