Results 91 to 100 of about 245,202 (346)

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression

Nature Cell Biology, 2022
De Huang, Yan Wang, J. Thompson, Tao Yin, Peter B. Alexander, Diyuan Qin, Poorva Mudgal, Haiyang Wu, Yaosi Liang, Lianmei Tan, C. Pan, Lifeng Yuan, Ying Wan, Qi-jing Li, Xiao-Fan Wang   +14 more
semanticscholar   +1 more source

An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance

Advanced Science, EarlyView.
This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue, Mao‐Xing Zhang, Xiao‐Chen Bi, Shou‐Peng Lai, Xin‐Tian Bie, Yuan Dong, Jian‐Feng Li, Fang Gao, Xia Zhang, Ying Wang   +9 more
wiley   +1 more source

Aluminum-Activated Malate Transporters Can Facilitate GABA Transport[OPEN]

The Plant Cell, 2018
GABA and malate interact with ALMTs to regulate each other’s transport, suggesting a role for ALMTs, which transport both GABA and malate in planta, in communicating metabolic status.
Sunita A. Ramesh, M. Kamran, W. Sullivan, Larissa Chirkova, M. Okamoto, F. Degryse, M. Mclaughlin, Matthew Gilliham, S. Tyerman   +8 more
semanticscholar   +1 more source

Biomimetic Analysis of Neurotransmitters for Disease Diagnosis through Light‐Driven Nanozyme Sensor Array and Machine Learning

Advanced Science, EarlyView.
A novel photoresponsive nanozyme sensor array, combining metal‐organic frameworks (MOFs) with advanced machine learning algorithms, provides a breakthrough in rapid neurotransmitter detection and disease diagnostics. This sensor array is capable of accurately identifying neurotransmitter profiles associated with neurological disorders, offering ...
Kun Yu, Siyuan Lu, Kaiwen Qiu, Yuanzun Zhang, Aobing Sun, Shiqi Gong, Kai Wang, Xuzhu Gao, Xiangyu Xu, Hao Wang   +9 more
wiley   +1 more source

Photocontrolled Release of Urea Enables the Detection of Urea–Urease Intermediates by Cryo‐FTIR

Angewandte Chemie, EarlyView.
Urease is a fast enzyme, presenting kcat of the order of 103–104 s−1. To enable the visualization of its mechanism we explored the technique of cryo‐FTIR. By means of using a ruthenium complex as a caged‐urea, upon light irradiation urea was released and we could see the coordination of the urea to the active site.
Caterina G.C. Marques Netto, Sarah Bell, Caio B. Castro, Pedro Henrique Machado, Vatsal Purohit, Katherine M. Davis, Ana Paula L. Batista, R. Brian Dyer   +7 more
wiley   +2 more sources

Microtubule Disruption Without Learning Impairment in the Unicellular Organism, Paramecium: Implications for Information Processing in Microtubules

Basic and Clinical Neuroscience, 2022
Introduction: Information processing in microtubules is an open question that has not been adequately addressed. It was suggested that microtubules could store and process information in the nervous system or even support consciousness.
Abolfazl Alipour, Gholamreza Hatam, Hassan Seradj   +2 more
doaj  

Effect of Phytohormones of Kinetin and Epibrassinolide on Content and Intracellular Localization of Glucosides and Free Amino Acids in Pea Plants Cells (Pisum sativum L.)

International Journal of Secondary Metabolite, 2018
During injection of kinetin and epibrassinolide in pea seedlings (Pisum sativum L.) an increase of content of specific for this compound isosuccinimide-β-glucoside (IS-glucoside) for 15-30%, ethyl-β-glucoside for 40-80%, GABA free amino acids, glutamate ...
Antonina N. Ershova, Natalia Vinokurova   +1 more
doaj   +1 more source

De novo synaptogenesis induced by GABA in the developing mouse cortex

Science, 2016
Dendrites of cortical pyramidal neurons contain intermingled excitatory and inhibitory synapses. We studied the local mechanisms that regulate the formation and distribution of synapses. We found that local γ-aminobutyric acid (GABA) release on dendrites
Won Chan Oh, S. Lutzu, P. Castillo, Hyung-Bae Kwon   +3 more
semanticscholar   +1 more source

Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative

Advanced Science, EarlyView.
Glioblastoma (GBM) is an aggressive brain cancer that often recurs and resists chemotherapy. This study found that a chemical called PGE2 causes surrounding brain cells (neurons) to become over‐excited, which makes GBM cells resistant to treatment. Researchers developed a new drug, “Compound 11,” which can cross into the brain and effectively block ...
Chih‐Jie Shen, Hsien‐Chung Chen, Chien‐Liang Lin, Amandeep Thakur, Raphael Onuku, I‐Chung Chen, Hao‐Yi Li, Kwang‐Yu Chang, Jian‐Ying Chuang, Wen‐Bin Yang, Hong‐Yi Lin, Yi‐Ru Shen, Jing‐Ping Liou, Wen‐Chang Chang, Tsung‐I Hsu   +14 more
wiley   +1 more source

Decreased serum level of gamma-amino butyric acid in egyptian infertile females with polycystic ovary syndrome is correlated with dyslipidemia, total testosterone and 25(OH) vitamin D levels [PDF]

Journal of Medical Biochemistry, 2019
Background: Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders around the world. Increasing evidence suggests that neurotransmitter Gamma-aminobutyric acid (GABA) is involved in the pathogenesis of PCOS through its ...
Radwan Rasha A., Abuelezz Nermeen Z., Abdelraouf Sahar M., Bakee Engy M., Abd-El-rahman Abdullah A.   +4 more
doaj