Results 121 to 130 of about 258,602 (310)

Safety and pharmacokinetics of a novel potent GABA analogue crisugabalin in Chinese subjects with various degrees of renal impairment

British Journal of Clinical Pharmacology, EarlyView.
Aims Crisugabalin is a novel calcium channel α2δ subunit ligand and a highly selective oral gamma‐aminobutyric acid (GABA) analogue developed for the treatment of diabetic peripheral neuropathic pain (DPNP) and postherpetic neuralgia (PHN). This study investigated pharmacokinetic properties and safety of crisugabalin in subjects with renal impairment ...
Shibeilei Lin, Ye Wang, Chao Hu, Yanhuan Feng, Xi Tang, Ping Fu, Jia Miao   +6 more
wiley   +1 more source

Integrating Astrocytes in the Sleep–Wake Cycle: The Time Is Now

BioEssays, EarlyView.
Astrocytes actively regulate sleep homeostatic and circadian rheostatic processes, underpinning the sleep–wake cycle. By acting as context‐dependent integrators of internal state and rhythmic environmental inputs, they modulate the encoding properties of neuronal circuitries and contribute to salient temporal representations in the brain.
Marco Brancaccio
wiley   +1 more source

Increased GABA_Breceptor function in mouse frontal cortex after repeated administration of antidepressant drugs or electroconvulsive shocks [PDF]

, 1987
Julian Gray, A. Richard Green
openalex   +1 more source

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Proceedings of the National Academy of Sciences of the United States of America, 2011
J. Bravo, P. Forsythe, Marianne V Chew, Emily Escaravage, H. Savignac, T. Dinan, J. Bienenstock, J. Cryan   +7 more
semanticscholar   +1 more source

The Effect of Exogenously Applied Dicarboxylic Acids (Photon) on the Maize (Zea mays) Metabolite Profile

Chemistry &Biodiversity, EarlyView.
ABSTRACT Maize is an important crop worldwide with approximately 1200 million tons consumed and a market size worth $143 billion. Environmental stress influence production of crops and mitigating these ensures optimum production. Dicarboxylic acids are known as emulsifying agents that mitigate various stresses in plants.
Mhlonipheni Msomi, Noluyolo Nogemane, Garland More, Gerhard Prinsloo   +3 more
wiley   +1 more source

Isolation of γ-Aminobutyric Acid (GABA)-Producing Lactic Acid Bacteria with Anti-Inflammatory Effects from Fermented Foods in Korea [PDF]

, 2023
Y.H. Kim, Trung Hau Nguyen, Jin-Seong Kim, Jeong-Yong Park, Chang-Ho Kang   +4 more
openalex   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Bioassay‐guided isolation of apigenin with GABA‐benzodiazepine activity from Tanacetum parthenium [PDF]

, 2009
Anna K. Jäger, K. Krydsfeldt, Henrik Rasmussen   +2 more
openalex   +1 more source

Photocleavable Systems for Cell Biology: Conceptual Design across Molecular Modalities

ChemBioChem, EarlyView.
Light‐triggered bond cleavage is an essential biotechnology in chemical biology research. This concept highlights three photocleavable modalities—proteins, small molecules, and metal complexes—distilling design principles for wavelength tuning, cleavage efficiency, and biocompatibility.
Masahiko Yoshimura, Tomoko Inose
wiley   +1 more source

Loss of GABA_B‐mediated interhemispheric synaptic inhibition in stroke periphery [PDF]

, 2018
Bojana Kokinovic, Paolo Medini
openalex   +1 more source