Results 121 to 130 of about 470,203 (387)

Identification, Classification and Screening for γ-Amino-butyric Acid Production in Lactic Acid Bacteria from Cambodian Fermented Foods

Biomolecules, 2019
Screening for various types of lactic acid bacteria (LAB) that form the biological agent γ-amino-butyric acid (GABA) is important to produce different kinds of GABA-containing fermented foods.
Dalin Ly, Sigrid Mayrhofer, I. B. Agung Yogeswara, Thu-Ha Nguyen, Konrad J. Domig   +4 more
doaj   +1 more source

Aging and GABA

Aging, 2018
sponsorship: This work was supported by the Research Fund KU Leuven (C16/15/070) and the Research Foundation Flanders (FWO) grant (G089818N) and Excellence of Science grant (EOS 30446199, MEMODYN) awarded to SPS. CM is funded by an aspirant fellowship of the Research Foundation Flanders (FWO).
Cuypers, Koen, Maes, Celine, Swinnen, Stephan   +2 more
openaire   +3 more sources

GABA‐producing Bifidobacterium dentium modulates visceral sensitivity in the intestine

Neurogastroenterology and Motility, 2016
Recurrent abdominal pain is a common and costly health‐care problem attributed, in part, to visceral hypersensitivity. Increasing evidence suggests that gut bacteria contribute to abdominal pain perception by modulating the microbiome‐gut‐brain axis ...
K. Pokusaeva, Chris W. Johnson, Chris W. Johnson, Berkley Luk, Berkley Luk, G. Uribe, Y. Fu, N. Oezguen, N. Oezguen, R. Matsunami, M. Lugo, Yuko Mori‐Akiyama, Yuko Mori‐Akiyama, E. Hollister, E. Hollister, Sara M. Dann, Xuan-Zheng Shi, D. Engler, Tor C. Savidge, Tor C. Savidge, James Versalovic, James Versalovic   +21 more
semanticscholar   +1 more source

Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor

Advanced Science, EarlyView.
Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang, Yixiang Deng, Nan Xia, Shuzo Sugita, Shangbang Gao   +4 more
wiley   +1 more source

Current concepts of pathogenesis of depressive disorder: A literature review

Research Results in Pharmacology
Introduction: Despite the high prevalence of depressive disorders, the pathogenesis of depression has not been fully established. Recently, a significant number of works have been published demonstrating mechanisms of development of this pathology that ...
Alexander A. Spasov, Dmitriy V. Maltsev, Maria O. Maltseva   +2 more
doaj   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

Pharmacological Discrimination of Effects of MK801 on Thalamocortical, Mesothalamic, and Mesocortical Transmissions

Biomolecules, 2019
N-methyl-d-aspartate/glutamate receptor (NMDAR) is one of the major voltage-sensitive ligand-gated cation channel. Several noncompetitive NMDAR antagonists contribute to pathophysiology of schizophrenia and mood disorders; however, the effects of ...
Motohiro Okada, Kouji Fukuyama, Tomosuke Nakano, Yuto Ueda   +3 more
doaj   +1 more source

Comparing GABA-dependent physiological measures of inhibition with proton magnetic resonance spectroscopy measurement of GABA using ultra-high-field MRI

NeuroImage, 2017
Imbalances in glutamatergic (excitatory) and GABA (inhibitory) signalling within key brain networks are thought to underlie many brain and mental health disorders, and for this reason there is considerable interest in investigating how individual ...
Katherine Dyke, Sophia E. Pépés, Chen Chen, Soyoung Kim, Hilmar P. Sigurdsson, A. Draper, M. Husain, P. Nachev, P. Gowland, P. Morris, S. Jackson   +10 more
semanticscholar   +1 more source

Polyelectrolyte Design Principles for Electrophoretic Drug Delivery

Advanced Science, EarlyView.
Structure–property–function mapping of polyelectrolytes reveals how composition and nanoscale order control on‐demand electrophoretic drug transport. Charge density quantified under implant‐relevant conditions shows that encapsulation limits swelling, enabling high effective charge density.
Helena Saarela Unemo, Iwona Bernacka‐Wojcik, Lingkai Zhu, Marle E. J. Vleugels, Moa E. Hörberg, Caroline Lindholm, Magnus Berggren, Daniel T. Simon, Theresia Arbring Sjöström   +8 more
wiley   +1 more source