Results 61 to 70 of about 258,602 (310)

Epilepsia idiopática em cães: Novos tratamentos e impactos sobre os animais e tutores

Pubvet, 2022
A convulsão é a manifestação clínica da atividade elétrica anormal do cérebro, é qualquer evento não específico, e epilepsia refere-se a múltiplas convulsões que ocorrem durante um longo período. Conceituar e compreender como a epilepsia influencia o bem-
Franciele Taiza Borges do Nascimento, Gabriela de Castro Freitas, Vitória Menezes Oliveira, Thais Miranda Silva Freitas   +3 more
doaj   +1 more source

GABA and l-theanine mixture decreases sleep latency and improves NREM sleep

Pharmaceutical Biology, 2019
Context: γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter and it is well established that activation of GABAA receptors favours sleep.
Suhyeon Kim, Kyungae Jo, Ki-Bae Hong, S. Han, H. Suh   +4 more
semanticscholar   +1 more source

Thermally Drawn Multifunctional All‐Hydrogel Fibers for Anti‐Fibrotic and Multimodal Neural Interfaces

Advanced Materials, EarlyView.
Hydrogels demonstrate material properties that mimic the mechanical and chemical environments of biological tissues. Yet, they face challenges during their integration into 3D interfaces. By identifying a class of thermoplastic hydrogels, a strategy is developed to pattern hydrogels in thermally drawn fibers.
Changhoon Sung, Kum Seok Nam, Yeji Kim, Honey Kang, Kanghyeon Kim, Chanwoong Yoon, Somin Lee, Ain Chung, Jiheong Kang, Young‐Gyun Park, Alan Jung Park, Haider Butt, Hyunwoo Yuk, Seongjun Park   +13 more
wiley   +1 more source

Efficient increase of ɣ-aminobutyric acid (GABA) content in tomato fruits by targeted mutagenesis

Scientific Reports, 2017
γ-Aminobutyric acid (GABA) is a non-proteinogenic amino acid that has hypotensive effects. Tomato (Solanum lycopersicum L.) is among the most widely cultivated and consumed vegetables in the world and contains higher levels of GABA than other major crops.
Satoko Nonaka, Chikako Arai, Mariko Takayama, C. Matsukura, H. Ezura   +4 more
semanticscholar   +1 more source

Cooperative Rh2(OAc)4/Chiral Phosphoric Acid‐Catalyzed (3 + 3)‐Cycloadditions of Pyrrole‐3‐Methides and Carbonyl Ylides

Advanced Synthesis &Catalysis, EarlyView.
A stereoselective one‐step (3 + 3)‐cycloaddition between in situ generated pyrrole‐3‐methides and carbonyl ylides has been developed using cooperative rhodium and chiral phosphoric acid catalysis. The reaction affords oxa‐bridged cyclohepta[1,2‐b]pyrroles bearing three stereogenic centers, including two quaternary ones, in high yields and ...
Philipp Stehr, Christoph Schneider
wiley   +1 more source

Modulation of brain glutamate dehydrogenase as a tool for controlling seizures

Acta Pharmaceutica, 2015
Glutamate (Glu) is a major excitatory neurotransmitter involved in epilepsy. Glu is synthesized by glutamate dehydrogenase (GDH, E.C. 1.4.1.3) and dysfunction of the enzymatic activity of GDH is associated with brain pathologies.
Rasgado Lourdes A. Vega, Reyes Guillermo Ceballos, Díaz Fernando Vega   +2 more
doaj   +1 more source

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Nature Metabolism, 2019
Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (γ-aminobutyric acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet homeostasis.
D. Menegaz, D. Hagan, Joana Almaça, C. Cianciaruso, R. Rodriguez-Diaz, J. Molina, Robert M. Dolan, M. Becker, Petra C. Schwalie, Petra C. Schwalie, R. Nano, Fanny Lebreton, Chen Kang, Chen Kang, Rajan Sah, Rajan Sah, H. Gaisano, P. Berggren, P. Berggren, P. Berggren, Steinunn Baekkeskov, Steinunn Baekkeskov, A. Caicedo, Edward A. Phelps, Edward A. Phelps   +24 more
semanticscholar   +1 more source

TVB C++: A Fast and Flexible Back‐End for The Virtual Brain

Advanced Science, EarlyView.
TVB C++ is a streamlined and fast C++ Back‐End for The Virtual Brain (TVB), designed to make it as flexible as TVB, and FAST. Another pillar is to be fully compatible with TVB so easy bindings can be created from Python. Users can easily configure TVB C++ to execute the same code but with enhanced performance and parallelism.
Ignacio Martín, Gorka Zamora‐López, Jan Fousek, Michael Schirner, Petra Ritter, Viktor Jirsa, Gustavo Deco, Gustavo Patow   +7 more
wiley   +1 more source

Cracking the Valence Code: Patterned Facial Kinematics and Neural Signatures of Emotional Expressions in Mice

Advanced Science, EarlyView.
An AI‐powered system decodes emotional valence from mouse facial expressions, identifying ear dynamics as key indicators. By integrating facial kinematics with synchronized neural recordings, this approach establishes a direct link between behavior and brain activity, advancing automated emotion recognition in animal models.
Yujia Chen, Ruiqing Hou, Zhinan Chen, Junli Lu, Si Chen, Shisheng Xiong, Jianfeng Feng, Trevor W. Robbins, Haitao Yan, Xiao Xiao   +9 more
wiley   +1 more source

Decreased serum level of gamma-amino butyric acid in egyptian infertile females with polycystic ovary syndrome is correlated with dyslipidemia, total testosterone and 25(OH) vitamin D levels [PDF]

Journal of Medical Biochemistry, 2019
Background: Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders around the world. Increasing evidence suggests that neurotransmitter Gamma-aminobutyric acid (GABA) is involved in the pathogenesis of PCOS through its ...
Radwan Rasha A., Abuelezz Nermeen Z., Abdelraouf Sahar M., Bakee Engy M., Abd-El-rahman Abdullah A.   +4 more
doaj