Results 251 to 260 of about 173,247 (311)
Movement Disorders, EarlyView.ABSTRACT Neuroimaging with positron emission tomography (PET) has been instrumental in elucidating neurobiological mechanisms behind therapeutical trials in Parkinson's disease (PD). A variety of medical and neurosurgical interventions have been evaluated using many radioligands that reveal molecular basis for target engagement and brain responses in ...
Vijay Dhawan +4 more
wiley +1 more source
GABAergic mechanisms of excitation and hypersynchrony in adult rat hippocampus [PDF]
, 2003 Uusisaari, Marylka
core
Medicinal Research Reviews, EarlyView.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source
A Clinically Applicable Positive Allosteric Modulator of GABA Receptors Promotes Human β-Cell Replication and Survival as well as GABA's Ability to Inhibit Inflammatory T Cells. [PDF]
J Diabetes Res, 2019 Tian J +4 more
europepmc +1 more source
The Understudied Landscape of Hidradenitis Suppurativa in Asian Skin of Colour Populations
JEADV Clinical Practice, EarlyView.
Anju George
wiley +1 more source
SMART MRS: A Simulated MEGA‐PRESS ARTifacts toolbox for GABA‐edited MRS
Magnetic Resonance in Medicine, EarlyView.Abstract Purpose To create a Python‐based toolbox to simulate commonly occurring artifacts for single voxel gamma‐aminobutyric acid (GABA)‐edited MRS data. Methods The toolbox was designed to maximize user flexibility and contains artifact, applied, input/output (I/O), and support functions.
Hanna Bugler +3 more
wiley +1 more source
Neuroprotection, EarlyView.Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal +2 more
wiley +1 more source
Elucidating the Three‐Dimensional Structure of Piracetam through Rotational Spectroscopy
ChemistryOpen, EarlyView.Neutral molecules of the nootropic drug piracetam are generated by laser ablation and structurally characterized by microwave spectroscopy. Two conformers differing in the exo/endo configuration of the pyrrolidine ring are detected, with exo being the predominant form.
S. Mato +4 more
wiley +1 more source
ChemistryOpen, EarlyView.This study evaluates the pharmacological properties of the aqueous extract of Atractylis aristata, focusing on its antioxidant, anti‐inflammatory, antibacterial, and sedative activities. Phytochemical analysis identifies bioactive compounds, while in vitro and in vivo tests demonstrate its therapeutic potential in addressing oxidative stress ...
Asma Abid +14 more
wiley +1 more source