Results 301 to 310 of about 171,989 (360)
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Glia, 1994
AbstractGABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors. In astrocytes, GABA activates Cl−‐specific channels that are modulated by barbiturates and benzodiazepines; however ...
Douglas D. Fraser +2 more
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AbstractGABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors. In astrocytes, GABA activates Cl−‐specific channels that are modulated by barbiturates and benzodiazepines; however ...
Douglas D. Fraser +2 more
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The Neurobiology of Gaba Receptors
2006Gamma-aminobutyric acid (GABA) was first identified in 1950 (Roberts 1950; Awapara 1950) in brain extracts of various animal species and was subsequently found to be the principal inhibitory neurotransmitter in the central nervous system (CNS). GABA is synthesized as a result of decarboxylation of glutamic acid and is released by neurons into the ...
SANNA, ENRICO, FOLLESA, PAOLO, BIGGIO G.
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Occurrence of GABA and GABA receptors in human spermatozoa
Molecular Human Reproduction, 1998Gamma-aminobutyric acid (GABA) concentrations in seminal plasma and washed spermatozoa from normal donors were assessed by a sensitive radioreceptor assay, and were detectable in both fractions. Specific binding of [3H]-muscimol was shown to be dependent on protein concentration, temperature and incubation time.
J C Calamera, M N Ritta, D E Bas
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GABA and GABA receptors in invertebrates
Seminars in Neuroscience, 1991Abstract GABA is the major inhibitory transmitter at invertebrate synapses in both the central and peripheral nervous systems. The receptors for GABA are well characterised electrophysiologically in a wide variety of invertebrate organisms but their biochemical and pharmacological profiles are less well defined. In general invertebrate GABA receptors
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Life Sciences, 2003
A number of important drugs act on GABA(A) receptors, pentameric GABA-gated chloride channels assembled from among 19 known subunits. In trying to discover the roles in the brain of the subunits and their combinations, with the goal of developing more selective drugs, one tool has been to reduce expression of the subunits and examine the functional ...
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A number of important drugs act on GABA(A) receptors, pentameric GABA-gated chloride channels assembled from among 19 known subunits. In trying to discover the roles in the brain of the subunits and their combinations, with the goal of developing more selective drugs, one tool has been to reduce expression of the subunits and examine the functional ...
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Phospholipids and the Gaba Receptor
1976Much interest has been focused on the role of phospholipids in the nervous system. For example, it has been suggested that these are intimately involved in the cholinergic receptor. De Robertis and his colleagues isolated proteolipids from mammalian nerve ending membranes and showed that they have a high affinity for d-tubocurarine and.
Cecilia T. Giambalvo +2 more
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Pharmacology of insect GABA receptors
Neurochemical Research, 1991A GABA-operated Cl- channel that is bicuculline-insensitive is abundant in the nervous tissue of cockroach, in housefly head preparations and thorax/abdomen preparations, and in similar preparations from several insect species. Bicuculline-insensitive GABA-operated Cl- channels, which are rare in vertebrates, possess sites of action of benzodiazepines,
Sattelle, David B. +3 more
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Trends in Pharmacological Sciences, 2000
In the conventional view, GABA acts at either ionotropic GABAA or metabotropic GABAB receptors. Recently, novel ionotropic GABA receptors that are composed of rho-subunits have been identified in the vertebrate retina. These bicuculline- and baclofen-insensitive GABA receptors are frequently called GABAC, following an early suggestion by Graham ...
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In the conventional view, GABA acts at either ionotropic GABAA or metabotropic GABAB receptors. Recently, novel ionotropic GABA receptors that are composed of rho-subunits have been identified in the vertebrate retina. These bicuculline- and baclofen-insensitive GABA receptors are frequently called GABAC, following an early suggestion by Graham ...
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Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1990
Comparaison des recepteurs GABA ergiques neuronaux des insectes avec ceux des vertebres apres analyse des liaisons de differents agents ...
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Comparaison des recepteurs GABA ergiques neuronaux des insectes avec ceux des vertebres apres analyse des liaisons de differents agents ...
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