Results 101 to 110 of about 80,549 (314)

Preclinical pharmacology of alogabat: a novel GABAA-α5 positive allosteric modulator targeting neurodevelopmental disorders with impaired GABAA signaling

Frontiers in Pharmacology
BackgroundAlterations in the GABAergic system contribute to the pathophysiology of neurodevelopmental disorders, including autism spectrum disorder (ASD) and Angelman syndrome (AS), particularly in cases involving large deletions in the 15q11–13 region ...
Giuseppe Cecere, Theresa M. Ballard, Frederic Knoflach, Michael Honer, Joerg F. Hipp, Pilar Garces, Thomas Mueggler, Basil Künnecke, Andreas Bruns, Eric P. Prinssen, Philipp Schoenenberger, Philipp Janz, Roger Redondo, Barbara Biemans, Henner Knust, Andrés Olivares-Morales, Alessandro Brigo, Jan Michael Schulz, Daniel Bertrand, Michael Saxe, Eoin C. O’Connor, Maria-Clemencia Hernandez   +21 more
doaj   +1 more source

Segregation of acetylcholine and GABA in the rat superior cervical ganglia: functional correlation.

Frontiers in Cellular Neuroscience, 2016
Sympathetic neurons have the capability to segregate their neurotransmitters (NTs) and co-transmitters to separate varicosities of single axons; furthermore, in culture, these neurons can even segregate classical transmitters. In vivo sympathetic neurons
Diana eElinos, Raúl eRodríguez, Luis Andres Martínez, María Elena Zetina, Fredy eCifuentes, Miguel Angel Morales   +5 more
doaj   +1 more source

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA) is a selective and competitive antagonist at the GABAA receptor site. [PDF]

, 1985
J. P. Chambón, P. Feltz, Michel Héaulme, S. Restle, Rémy Schlichter, Kathleen Bizière, Camille G. Wermuth   +6 more
openalex   +1 more source

Synaptic inhibitory dynamics drive benzodiazepine response in pediatric status epilepticus

Epilepsia, EarlyView.
Abstract Objective Pediatric status epilepticus (SE) is a medical emergency associated with significant morbidity. Benzodiazepines (BZPs) are the current first‐line treatment, but do not work in more than one third of children presenting with SE. Animal studies have shown that SE can cause changes in synaptic inhibition signaling that can ultimately ...
Tommaso Fedele, Richard J. Burman, Anne Steinberg, Giorgio Selmin, Georgia Ramantani, Richard E. Rosch   +5 more
wiley   +1 more source

Increased motor-impairing effects of the neuroactive steroid pregnanolone in mice with targeted inactivation of the GABAA receptor gamma2 subunit in the cerebellum

Frontiers in Pharmacology, 2016
Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABAA receptors. In recombinant receptors and genetic mouse models their actions depend on the alpha, beta and delta subunits of the receptor,
Elli Leppä, Anni-Maija Tuulikki Linden, M. Isabel Aller, Peer Wulff, Olga Vekovischeva, Bernhard Lüscher, Hartmut Lüddens, William Wisden, Esa R Korpi   +8 more
doaj   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité   +1 more
wiley   +1 more source

Generation of recombinant antibodies to rat GABAA receptor subunits by affinity selection on synthetic peptides.

PLoS ONE, 2014
The abundance and physiological importance of GABAA receptors in the central nervous system make this neurotransmitter receptor an attractive target for localizing diagnostic and therapeutic biomolecules.
Sujatha P Koduvayur, Hélène A Gussin, Rajni Parthasarathy, Zengping Hao, Brian K Kay, David R Pepperberg   +5 more
doaj   +1 more source

Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture. [PDF]

, 1989
Robert L. Macdonald, Connie J. Rogers, Roy E. Twyman   +2 more
openalex   +1 more source

Status epilepticus in older adults: A critical review

Epilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward, Michael J. Armahizer, Tina I. Wang, Neeraj Badjatia, Emily L. Johnson, Emily J. Gilmore   +5 more
wiley   +1 more source