Results 31 to 40 of about 2,290,618 (347)

Impairment of GABA inhibition in insomnia disorders: Evidence from the peripheral blood system

Frontiers in Psychiatry, 2023
AimTo explore the change characteristics and related factors of various indexes of GABAergic system in peripheral blood of patients with insomnia disorder.MethodsIn this study, a total of 30 patients who met the DSM-5 diagnostic criteria for insomnia ...
Ting Xiang, Ting Xiang, Jiwu Liao, Yixian Cai, Yixian Cai, Mei Fan, Mei Fan, Congrui Li, Xiaotao Zhang, Hongyao Li, Yushan Chen, Jiyang Pan, Jiyang Pan   +12 more
doaj   +1 more source

Crystal structure of a human GABAA receptor

Nature, 2014
Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers hyperactive neurological disorders such as insomnia, anxiety and epilepsy ...
Paul S. Miller, A. Aricescu
semanticscholar   +1 more source

Molecular mechanisms, physiological roles, and therapeutic implications of ion fluxes in bone cells: Emphasis on the cation‐Cl− cotransporters

Journal of Cellular Physiology, Volume 237, Issue 12, Page 4356-4368, December 2022., 2022
Ion transport systems in the membranes of osteoblasts and osteoclasts play a key role in bone remodeling by coordinating the movement of Ca2+, PO42−, and H+ ions in and out of the osseous matrix. Based on the evidence available, the cation‐Cl− cotransporters could act as unexpectedly important players in this regard.
Alexandre P. Garneau, Samira Slimani, Ludwig Haydock, Thy‐René Nsimba‐Batomene, Florence C.M. Préfontaine, Mathilde M. Lavoie, Laurence E. Tremblay, Marie‐Jeanne Fiola, Fabrice Mac‐Way, Paul Isenring   +9 more
wiley   +1 more source

The seizure‐inducing plastic explosive RDX inhibits the α1β2γ2 GABAA receptor

Annals of Clinical and Translational Neurology, 2022
Objective Royal demolition explosive (RDX) can induce seizures in wildlife and humans following release into the environment or after voluntary consumption.
Brandon Pressly, Ruth D. Lee, Vikrant Singh, Isaac N. Pessah, Heike Wulff   +4 more
doaj   +1 more source

Motor cortical excitability and pre‐supplementary motor area neurochemistry in healthy adults with substantia nigra hyperechogenicity

Journal of Neuroscience Research, Volume 101, Issue 2, Page 263-277, February 2023., 2023
Substantia nigra (SN) hyperechogenicity, viewed with transcranial ultrasound, is a risk marker for Parkinson's disease. SN hyperechogenicity in healthy older adults is associated with changes in the excitability of specific motor cortical circuitry. These changes are unrelated to glutamate levels in the pre‐supplementary motor area (pre‐SMA).
Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna‐Katharina von Thaler, Clarence Chiang, Kay L. Double   +18 more
wiley   +1 more source

Photo-antagonism of the GABAA receptor [PDF]

Nature Communications, 2014
AbstractNeurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility and function at inhibitory synapses is derived indirectly from using recombinant receptors ...
Mortensen, M, Iqbal, F, Pandurangan, AP, Hannan, S, Huckvale, R, Topf, M, Baker, JR, Smart, TG   +7 more
openaire   +5 more sources

Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]

EMBO J 22, 18 (15/09/2003) 4656-65, 2007
Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv   +1 more source

Two Distinct Populations of α1α6-Containing GABAA-Receptors in Rat Cerebellum

Frontiers in Synaptic Neuroscience, 2020
GABAA receptors are pentameric GABA-gated chloride channels. The existence of 19 different subunits (six α, three β, three γ, δ, ε, θ, π, and three ρ) in mammalian systems gives rise to an enormous theoretical diversity of GABAA receptor subtypes with ...
Petra Scholze, Michael Pökl, Severin Längle, Friederike Steudle, Jure Fabjan, Margot Ernst   +5 more
doaj   +1 more source

GABAA receptor autoimmunity

Neurology: Neuroimmunology & Neuroinflammation, 2019
Objective We sought to validate methods for detection and confirmation of GABAA receptor (R)-IgG and clinically characterize seropositive cases. Methods Archived serum and CSF specimens (185 total) suspected to harbor GABAAR-IgG were evaluated by ...
K. O'Connor, P. Waters, L. Komorowski, A. Zekeridou, Chu-Yueh Guo, V. Mgbachi, C. Probst, S. Mindorf, B. Teegen, J. Gelfand, M. Geschwind, V. Lennon, S. Pittock, A. McKeon   +13 more
semanticscholar   +1 more source

GABAA receptor availability is not altered in adults with autism spectrum disorder or in mouse models

Science Translational Medicine, 2018
There are no alterations in GABAA receptor availability in adults with autism spectrum disorder or in commonly used rodent models of the condition. A window into the ASD brain A leading hypothesis for autism spectrum disorder (ASD) is that this condition
J. Horder, M. Andersson, M. Mendez, Nisha Singh, Ä. Tangen, J. Lundberg, A. Gee, C. Halldin, M. Veronese, S. Bölte, L. Farde, T. Sementa, D. Cash, Karen Higgins, Debbie Spain, F. Turkheimer, I. Mick, S. Selvaraj, D. Nutt, A. Lingford-Hughes, O. Howes, D. Murphy, J. Borg   +22 more
semanticscholar   +1 more source