Results 31 to 40 of about 80,549 (314)
Two Distinct Populations of α1α6-Containing GABAA-Receptors in Rat Cerebellum
Frontiers in Synaptic Neuroscience, 2020 GABAA receptors are pentameric GABA-gated chloride channels. The existence of 19 different subunits (six α, three β, three γ, δ, ε, θ, π, and three ρ) in mammalian systems gives rise to an enormous theoretical diversity of GABAA receptor subtypes with ...
Petra Scholze +5 more
doaj +1 more source
Evidence for a GABAergic system in rodent and human testis: Local GABA production and GABA receptors [PDF]
, 2003 The major neurotransmitter of the central nervous system, gamma-aminobutyric acid (GABA), exerts its actions through GABA(A), GABA(B) and GABA(C) receptors.
Calandra, Ricardo S. +7 more
core +2 more sources
PLoS ONE, 2015 A developmental "switch" in chloride transporters occurs in most neurons resulting in GABAA mediated hyperpolarization in the adult. However, several neuronal cell subtypes maintain primarily depolarizing responses to GABAA receptor activation.
Carol Taylor-Burds +2 more
doaj +1 more source
Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue. [PDF]
, 2012 Photochemical switches represent a powerful method for improving pharmacological therapies and controlling cellular physiology. Here we report the photoregulation of GABA(A) receptors (GABA(A)Rs) by a derivative of propofol (2,6-diisopropylphenol), a ...
Bruzik, Karol S +8 more
core +2 more sources
GABAA Receptors at Hippocampal Mossy Fibers [PDF]
Neuron, 2003 Presynaptic GABAA receptors modulate synaptic transmission in several areas of the CNS but are not known to have this action in the cerebral cortex. We report that GABAA receptor activation reduces hippocampal mossy fibers excitability but has the opposite effect when intracellular Cl- is experimentally elevated.
Matthew C. Walker +5 more
openaire +3 more sources
Synthetic epoxy-pregnan steroids: effects on anxiety behavior in rats [PDF]
, 2016 Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for therapeutical pruposes like ...
Coirini, Hector +2 more
core +1 more source
Plasticity of GABAA Receptors during Pregnancy and Postpartum Period: From Gene to Function
Neural Plasticity, 2015 Pregnancy needs complex pathways that together play a role in proper growth and protection of the fetus preventing its premature loss. Changes during pregnancy and postpartum period include the manifold machinery of neuroactive steroids that plays a ...
Valentina Licheri +5 more
doaj +1 more source
Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]
, 2011 GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Crunelli, Vincenzo +2 more
core
Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]
, 2017 A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa +3 more
core +1 more source
Central Dysmyelination in SSADH‐Deficient Humans and Mice
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer +11 more
wiley +1 more source