Results 41 to 50 of about 2,290,618 (347)
The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease
Brain Pathology, Volume 33, Issue 1, January 2023., 2023 Abstract Alzheimer's disease (AD) is the most common neurological disease, which is associated with gradual memory loss and correlated with synaptic hyperactivity and abnormal oscillatory rhythmic brain activity that precedes phenotypic alterations and is partly responsible for the spread of the disease pathology.
Afia B. Ali +2 more
wiley +1 more source
Large number of receptors may reduce cellular response time variation [PDF]
Physical biology 10 (3), 035008, 2013, 2012 Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv +1 more source
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
PLoS ONE, 2015 A developmental "switch" in chloride transporters occurs in most neurons resulting in GABAA mediated hyperpolarization in the adult. However, several neuronal cell subtypes maintain primarily depolarizing responses to GABAA receptor activation.
Carol Taylor-Burds +2 more
doaj +1 more source
Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?
Frontiers in Molecular Neuroscience, 2016 Atomic resolution structures of cys-loop receptors, including one of a γ-aminobutyric acid type A receptor (GABAA receptor) subtype, allow amazing insights into the structural features and conformational changes that these pentameric ligand-gated ion ...
Roshan Puthenkalam +6 more
semanticscholar +1 more source
European Journal of Neuroscience, Volume 56, Issue 12, Page 6187-6200, December 2022., 2022 Motor imagery (MI) refers to the mental simulation of an action without overt movement. As MI is an important field of research in cognitive neuroscience and motor rehabilitation, it essential to decipher the neural circuits underlying imagined movements.
Cécilia Neige +2 more
wiley +1 more source
Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]
arXiv, 2022 The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv
Drug resistance in idiopathic generalized epilepsies: Evidence and concepts
Epilepsia, Volume 63, Issue 12, Page 3007-3019, December 2022., 2022 Abstract Although approximately 10%–15% of patients with idiopathic generalized epilepsy (IGE)/genetic generalized epilepsy remain drug‐resistant, there is no consensus or established concept regarding the underlying mechanisms and prevalence. This review summarizes the recent data and the current hypotheses on mechanisms that may contribute to drug ...
Joanna Gesche, Christoph P. Beier
wiley +1 more source
Neurosteroid involvement in threatened preterm labour
Endocrinology, Diabetes & Metabolism, 2021 Introduction The neurosteroid allopregnanolone modulates oxytocin expression in the brain, and its effects arise from its action on the GABAA receptor. Whether neurosteroid levels and the function of the GABAA receptor are involved in the risk of preterm
Sahruh Turkmen +3 more
doaj +1 more source
Method for identification of condition-associated public antigen receptor sequences [PDF]
eLife 2018;7:e33050, 2017 Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv +1 more source