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Molecular Biology of the GABAA Receptor
1988The GABAA receptorreceptor is the major molecular site of the ubiquitous inhibitory acEivities of the brain, being present on the great majority of mammalian brain neurones (1). Electrophysiological studies and, especially, recent patch-clamp studies on cultured neurones (2,3) have established that at these sites GABA opens a chloride channel which is ...
Barnard, E. +9 more
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Neurosteroid modulation of GABAA receptors
Progress in Neurobiology, 2003Certain metabolites of progesterone and deoxycorticosterone are established as potent and selective positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor. Upon administration these steroids exhibit clear behavioural effects that include anxiolysis, sedation and analgesia, they are anticonvulsant and at high doses ...
Lambert, Jeremy J. +4 more
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Molecular Neurobiology of the GabaA Receptor
1994Publisher Summary This chapter discusses the molecular neurobiology of the GABAA receptor. The GABAA receptor is responsible for the majority of neuronal inhibition in the vertebrate CNS. The ubiquitous distribution of the GABAA receptor in the mammalian CNS is revealed by the use of [3H]GABA radioligand binding techniques, whereas autoradiographic ...
Alan N. Bateson +2 more
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1996
Transmitter-gated ion channels are multisubunit membrane-spanning receptors that serve as rapid signal transduction devices regulating the flow of cations or anions through the cell membrane. Cell type—specific flexibility in neurotransmission is accomplished by a multiplicity of channel variants based on the combinatorial assembly of structurally ...
Bernhard Lüscher +5 more
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Transmitter-gated ion channels are multisubunit membrane-spanning receptors that serve as rapid signal transduction devices regulating the flow of cations or anions through the cell membrane. Cell type—specific flexibility in neurotransmission is accomplished by a multiplicity of channel variants based on the combinatorial assembly of structurally ...
Bernhard Lüscher +5 more
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Pharmacology & Therapeutics, 1995
gamma-Aminobutyric acid (GABA)A receptors for the inhibitory neurotransmitter GABA are likely to be found on most, if not all, neurons in the brain and spinal cord. They appear to be the most complicated of the superfamily of ligand-gated ion channels in terms of the large number of receptor subtypes and also the variety of ligands that interact with ...
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gamma-Aminobutyric acid (GABA)A receptors for the inhibitory neurotransmitter GABA are likely to be found on most, if not all, neurons in the brain and spinal cord. They appear to be the most complicated of the superfamily of ligand-gated ion channels in terms of the large number of receptor subtypes and also the variety of ligands that interact with ...
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Inhibitory Neurosteroids and the GABAA Receptor
2015γ-Aminobutyric acid type A receptors (GABAARs) are vital proteins that are engaged in regulating neural circuit activity in the central nervous system. Their effectiveness in this task is dependent on the extent of receptor modulation by naturally occurring ligands that are released in the brain.
Sandra Seljeset +2 more
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Trends in Neurosciences, 1996
In a recent issue, a review addressed the important question of which GABAA-receptor subtypes occur in our brain1xMcKernan, R.M. and Whiting, P.J. Trends Neurosci. 1996; 19: 139–143Abstract | Full Text PDF | PubMed | Scopus (939)See all References1.
Kai Kannenberg, Erwin Sigel
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In a recent issue, a review addressed the important question of which GABAA-receptor subtypes occur in our brain1xMcKernan, R.M. and Whiting, P.J. Trends Neurosci. 1996; 19: 139–143Abstract | Full Text PDF | PubMed | Scopus (939)See all References1.
Kai Kannenberg, Erwin Sigel
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The benzodiazepine binding site of GABAA receptors [PDF]
Trends in Pharmacological Sciences, 1997 The GABAA receptor belongs, along with the nicotinic acetylcholine receptor, the glycine receptor and the 5-HT3 receptor, to a family of homologous transmitter-gated ion channels mediating fast synaptic transmission. Many classes of drug interact with the GABAA receptor, which is the major inhibitory ion channel in the mammalian brain.
Erwin Sigel, Andreas Buhr
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Role of GABAA receptors in cognition
Biochemical Society Transactions, 2009Complex brains have developed specialized mechanisms for the grouping of principal cells into temporal coalitions of local or distant networks: the inhibitory interneuron ‘clocking’ networks. They consist of GABAergic (where GABA is γ-aminobutyric acid) interneurons of a rich diversity.
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Barbiturates and the GABAA receptor complex
1990The GABA synapse plays an important role in the pharmacologic effects of barbiturates and the mechanisms involved in barbiturate tolerance and dependence. A synopsis of the effects which have been reported to date is found in Tables 1 and 2. Although the acute changes in neurotransmitter uptake and release are nonselective, a lag in the ability of the ...
Ing K. Ho, Paul A. Saunders
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