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Cyclothiazide binding to the GABAA receptor
Neuroscience Letters, 2008In order to explore the molecular interaction between cyclothiazide (CTZ) and gamma-aminobutyric acidA (GABAA) receptors, possibly underlying inhibition of GABAA receptor currents, [3H]-CTZ was synthesized. Binding of [3H]-CTZ to rat brain synaptic membranes could be observed only in the presence of the GABAA receptor antagonist (-)[1S,9R]-bicuculline ...
Zoltán Banka +8 more
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Surface Expression of GABAA Receptors
Journal of Oral Biosciences, 2010Abstract The transmission of sensory information to the central nervous system during oral functions such as mastication and swallowing is well regulated by neural networks, including γ-aminobutyric acid (GABA)-mediated inhibitory interneurons. Therefore, an understanding of the mechanism of GABAergic transmission might provide new insight into the ...
Hiroto Tanaka +5 more
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Neurosteroids and GABAA receptor function
Trends in Pharmacological Sciences, 1995In 1984, a potent and selective interaction of the steroidal anaesthetic alphaxalone with the GABAA receptor was demonstrated. Subsequent studies established that certain naturally occurring steroids were potent positive allosteric modulators of the GABAA receptor.
Lambert, Jeremy J. +3 more
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Multiplicity of GABAA-benzodiazepine receptors
Trends in Pharmacological Sciences, 1989Binding studies suggest the presence of at least two pharmacologically distinct 'central' benzodiazepine receptors in the brain. Since central benzodiazepine receptors are allosteric modulatory sites on GABAA receptors, this evidence indirectly points to the existence of at least two GABAA receptors.
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2001
Studies of human diseases of the nervous system have demonstrated that many of the disorders result from disruption of normal developmental processes which promote organization and maturation of neuronal circuitry. Such disorders include many different forms of inherited childhood epilepsies in which genetic factors contribute to the abnormal ...
H. Y. Kim, R. W. Olsen
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Studies of human diseases of the nervous system have demonstrated that many of the disorders result from disruption of normal developmental processes which promote organization and maturation of neuronal circuitry. Such disorders include many different forms of inherited childhood epilepsies in which genetic factors contribute to the abnormal ...
H. Y. Kim, R. W. Olsen
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Spectrum of GABAA receptor variants in epilepsy
Current Opinion in Neurology, 2019Purpose of review Recent publications point to an increasingly important role of variants in genes encoding GABAA receptor subunits associated with both common and rare forms of epilepsies. The aim of this review is to give an overview of the current clinical phenotypes, genetic findings and pathophysiological mechanisms ...
Maljevic, Snezana +6 more
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2014
γ-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain and its actions are mediated by two diverse families of neurotransmitter receptors, the ionotropic receptors, known as GABAA receptors, and metabotropic receptors that are classified as GABAB receptors.
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γ-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain and its actions are mediated by two diverse families of neurotransmitter receptors, the ionotropic receptors, known as GABAA receptors, and metabotropic receptors that are classified as GABAB receptors.
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The GABAA receptor family in the mammalian brain
Neurochemical Research, 1991The GABAA-benzodiazepine receptor protein from bovine brain was purified by affinity chromatography and the subunit composition examined by gel electrophoresis in sodium dodecyl sulfate. Protein staining revealed a doublet at 51-53 kDa, a band at 55 kDa, and a broad band at 57-59 kDa.
Geoffrey B. Smith +3 more
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2010
Publisher Summary This chapter discusses the gamma-aminobutyric acid (GABA) receptor channels, which are the most abundant inhibitory neurotransmitter in the CNS. Following release from presynaptic vesicles, GABA exerts fast inhibitory effects by interacting with GABA receptors, whose primary function is to hyperpolarize neuronal membranes in mature ...
Emmanuel J. Botzolakis +1 more
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Publisher Summary This chapter discusses the gamma-aminobutyric acid (GABA) receptor channels, which are the most abundant inhibitory neurotransmitter in the CNS. Following release from presynaptic vesicles, GABA exerts fast inhibitory effects by interacting with GABA receptors, whose primary function is to hyperpolarize neuronal membranes in mature ...
Emmanuel J. Botzolakis +1 more
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Schizophrenia and GABAA receptor subunit genes
Psychiatric Genetics, 1995Alterations in gamma-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for the GABAA receptor alpha 1, alpha 2, alpha 4, alpha 5, alpha 6, beta 1 and beta 3 subunit genes ...
Robert Freedman +14 more
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