Results 81 to 90 of about 37,863 (118)

Plasticity of the α4βδ GABAA receptor

Biochemical Society Transactions, 2009
The GABAR [GABAA (γ-aminobutyric acid type A) receptor], which mediates most inhibition in the brain, is regulated homoeostatically to maintain an optimal level of neuronal excitability. In particular, the α4βδ subtype of the GABAR plays a pivotal role in this regulation.
Sheryl S. Smith, Hui Shen
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Hijacking of GABAA Receptors by Mutant Glycine Receptors

Trends in Molecular Medicine, 2019
Startle disease results from mutations in genes encoding inhibitory GlyR α1 and β subunits or the presynaptic glycine transporter GlyT2. However, the most effective therapies are benzodiazepines that potentiate inhibitory GABAAR function. A recent publication by Zou et al.
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Tyrosine kinase phosphorylation of GABAA receptors

Molecular Brain Research, 1995
Phosphorylation of purified bovine brain GABAA receptors by the tyrosine kinase, pp60v-src was examined. pp60v-src phosphorylated two bands of 54-62 kDa and 48-51 kDa that migrated to approximately the same position as bands recognized by antisera against the beta 2 and gamma 2 GABAA receptor subunits, respectively.
Geoffrey B. Smith, James L. McManaman, Richard W. Olsen, R. Adron Harris, R. Adron Harris, Tina K. Machu, Ruth M. McKernan, Susan J. Brozowski, Paul J. Whiting, Barbara B. VanRenterghem, C. Fernando Valenzuela   +10 more
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The Selective Interaction of Neurosteroids with the GABAA Receptor

1999
Some endogenous pregnane steroids have long been known to produce rapid sedative and anesthetic effects (1). The speed of onset of these behavioral effects precludes a genomic mechanism of action for such steroids, but it was not until Harrison and Simmonds (2)demonstrated that a synthetic steroidal anesthetic, alphaxalone (3α-hydroxy-5α-pregnane-11,20-
LAMBERT J. J., BELELLI D., SHEPHERD S. E., PISTIS, MARCO, PETERS J. A.   +4 more
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Modulation of the GABAA receptor by steroids

Seminars in Neuroscience, 1991
Abstract The functioning of the GABA A receptor-chloride ion channel is subject to several modulatory influences. Facilitation by benzodiazepines and barbiturates and antagonism by picrotoxin involve separate sites on the GABA A protein that are each distinct from the γ-aminobutyric acid (GABA) recognition site.
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Electrophysiology of GABAA and GABAB receptor subtypes

Trends in Neurosciences, 1988
Abstract The participation of GABA receptors in the inhibitory transmission at mammalian central synapses was demonstrated experimentally two decades ago. Whilst the ‘classical' action of GABA involves the opening of Cl − channels, pharmacologically distinct effects of GABA on cation channels were detected later. This led to the notion of GABA A and
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Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Probing the GABAA receptor with antibodies

Biochemical Society Transactions, 1991
Anthony J. Turner, Kate B. Widdows, Ewen F. Kirkness   +2 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-vornhagen, Victoria Metaxa, Elie Azoulay   +2 more
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul H Parikh
exaly