Results 111 to 120 of about 39,325 (214)

NMDA and glycine receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells

The Journal of Physiology, Volume 604, Issue 12, Page 4926-4944, 15 June 2026.
Abstract figure legend Vibrodissociated Pukinje neurons retain active synaptic connections, including those from adhering fragments of the climbing fibre. These fragments generate excitatory synaptic events and the frequency of these events is increased by exposure to either NMDA [with d‐serine (d‐ser) as a co‐agonist] or glycine at a high (100 µM ...
David C. H. Benton, Alan D. Robertson, Matthew Caldwell, Yuriy Pankratov, Lema Imam, Trevor G. Smart, Gareth Morris, Guy W. J. Moss   +7 more
wiley   +1 more source

Molecular assemblies and pharmacology of cerebellar GABA_A receptors. [PDF]

Proc Natl Acad Sci U S A
Sun C, Jahncke JN, Wright KM, Gouaux E.
europepmc   +1 more source

The endogenous cannabinoid system gates plasticity of tonic GABA inhibition

The Journal of Physiology, Volume 604, Issue 12, Page 4984-5010, 15 June 2026.
Abstract figure legend Postsynaptic depolarisation and increases in intracellular Ca2+ ([Ca2+]i) trigger the synthesis of endocannabinoids (eCBs), which are hypothesised to enhance tonic GABAergic inhibition via two primary pathways. In the proposed autocrine mechanism, eCBs activate postsynaptic somatodendritic or mitochondrial CB1 receptors ...
Roberto Colangeli, Fiorenzo Conti
wiley   +1 more source

Recurrent neonatal seizures increase tonic inhibition and respond to enhancers of δ-containing GABAA receptors. [PDF]

JCI Insight
Liddiard GT, Buchanan GF, Schultz ML, Glykys J.   +3 more
europepmc   +1 more source

Structural insights into opposing actions of neurosteroids on GABA_A receptors. [PDF]

Nat Commun, 2023
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE.   +7 more
europepmc   +1 more source

Substituted cysteine modification and protection indicates selective interactions of the anesthetic photolabel pTFD-di-iPr-BnOH with α+/β- and α+/γ- transmembrane subunit interfaces of synaptic GABAA receptors. [PDF]

PLoS One
Bhave K, Forman SA.
europepmc   +1 more source

GABA_A receptors as plausible molecular targets and mediators for taurine and homotaurine actions. [PDF]

Front Pharmacol, 2023
Meera P, Uusi-Oukari M, Lipshutz GS, Wallner M.   +3 more
europepmc   +1 more source

Understanding the relationship between lung GABA_A receptors and aquaporin-1: a new therapeutic approach for acute lung injury. [PDF]

BMC Pulm Med
Halici H, Karakoy Z, Cadirci E, Halici Z, Ozdemir B, Toktay E.   +5 more
europepmc   +1 more source

GABA_A receptors as targets for treating affective and cognitive symptoms of depression. [PDF]

Trends Pharmacol Sci, 2023
Luscher B, Maguire JL, Rudolph U, Sibille E.   +3 more
europepmc   +1 more source

The Mechanism of Enantioselective Neurosteroid Actions on GABA_A Receptors. [PDF]

Biomolecules, 2023
Tateiwa H, Chintala SM, Chen Z, Wang L, Amtashar F, Bracamontes J, Germann AL, Pierce SR, Covey DF, Akk G, Evers AS.   +10 more
europepmc   +1 more source