Results 101 to 110 of about 8,190 (170)
APP modulates KCC2 expression and function in hippocampal GABAergic inhibition
eLife, 2017 Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function is still poorly understood. We previously showed that GABAergic short-term plasticity is impaired in App knock-out (App-/-) animals, but the precise mechanism by which ...
Ming Chen +15 more
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Developmental Alterations in Inhibitory Neurotransmission in the Fragile X Syndrome Mouse Basolateral Amygdala [PDF]
, 2012 Fragile X Syndrome, caused by Fmr1 gene inactivation, is characterized by symptoms including enhanced fear, hyperactivity, social anxiety, and autism, pointing to synaptic and neural circuit defects in the amygdala. Previous studies in Fmr1 knockout (KO)
Sebila Kratovac, Kratovac, Sebila
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Frontiers in Cellular NeuroscienceGABAA receptors (γ-aminobutyric acid-gated receptors type A; GABAARs), the major structural and functional postsynaptic components of inhibitory synapses in the mammalian brain, belong to a family of GABA-gated Cl−/HCO3− ion channels.
Yusheng Sui +5 more
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Neural Plasticity, 2017 Studies have found that early traumatic experience significantly increases the risk of posttraumatic stress disorder (PTSD). Gamma-aminobutyric acid (GABA) deficits were proposed to be implicated in development of PTSD, but the alterations of GABA ...
Cui Yan Lu +5 more
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Early developmental changes in GABAA receptor expression in nucleus accumbens medium spiny neurons
Frontiers in NeuroscienceThe expression of GABAARs goes through large scale, evolutionarily conserved changes through the early postnatal period. While these changes have been well-studied in brain regions such as the hippocampus and sensory cortices, less is known about early ...
Ziyi (Zephyr) Wang +9 more
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, 2016 The A type γ-aminobutyric acid receptor (GABAAR) mediates major inhibition to counteract glutamate receptor-mediated excitation in the Central Nervous System (CNS).
Wen, Ya
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, 2019 The γ-Aminobutyric Acid A Receptor (GABAAR) is a ligand-gated, pentameric chloride channel composed of subunits that include α1-6, β1-3, γ1-3, δ, ε, π, θ, ρ1-3.1-2 The most common arrangement includes two α subunits, two β subunits, and a γ subunit.3 ...
Nieman, Amanda Nicole
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GABA Type A receptors expressed in triple negative breast cancer cells mediate chloride ion flux
Frontiers in PharmacologyTriple negative breast cancer (TNBC) is known for its heterogeneous nature and aggressive onset, limited unresponsiveness to hormone therapies and immunotherapy as well as high likelihood of metastasis and recurrence. Since no targeted standard treatment
J Bundy +6 more
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Novel inhibitors of LIM kinase and GABAAR-α5 to enable therapeutics in neurological disorders
The thesis herein describes novel approaches to targeting key biological markers identified in the pathology of two disparate inherited neurological diseases; Fragile X Syndrome and Huntington’s Disease.
Ashall-Kelly, Alexander
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Turn-on型蛍光プローブを用いたGABAA受容体の可視化
, 2018 γ−アミノ酪酸(γ-aminobutyric acid: GABA)は脳における主要な抑制性神経伝達物質であり、その作用は主に GABAA 受容体(GABAAR)を介して行われている。脳機能の詳細な理解のためには、GABAAR を可視化し、その挙動を解析することが重要である。これまでに当研究室では、合成小分子プローブを用いた化学修飾法であるリガンド指向性化学により、GABAAR の選択的な蛍光ラベル化に成功している 1)。この過程で我々は、あるラベル化剤の蛍光が培地中では弱められていることに気がついた ...
656198 +11 more
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