Results 81 to 90 of about 914,049 (192)

Median raphe glutamatergic neuron-mediated enhancement of GABAergic transmission and suppression of long-term potentiation in the hippocampus

Heliyon
The ascending neuromodulatory pathway from the median raphe nucleus (MRN) extends widely throughout midline/para-midline regions and robustly innervates the hippocampus. This neuromodulatory pathway is believed to be critical for regulating emotional and
Hannah E. Stinson, Ipe Ninan
doaj   +1 more source

Neuronal excitation-inhibition imbalance in the basolateral amygdala is involved in propofol-mediated enhancement of fear memory

Communications Biology
Posttraumatic stress disorder (PTSD) is associated with glutamatergic neuron hyperactivation in the basolateral amygdala (BLA) brain area, while GABAergic interneurons in the BLA modulate glutamatergic neuron excitability.
Chen Chen, Shuai Li, Yue Zhou, Hui Huang, Jia-Tao Lin, Wei-Feng Wu, Yong-Kang Qiu, Wei Dong, Jie Wan, Qiang Liu, Hui Zheng, Yu-Qing Wu, Cheng-Hua Zhou   +12 more
doaj   +1 more source

Necdin Promotes GABAergic Neuron Differentiation in Cooperation with Dlx Homeodomain Proteins

Journal of Neuroscience, 2006
Necdin, a member of the MAGE (melanoma antigen) protein family, is expressed predominantly in terminally differentiated neurons. The necdin gene NDN is maternally imprinted and expressed only from the paternal allele, the deficiency of which is ...
Takaaki Kuwajima, Isao Nishimura, K. Yoshikawa   +2 more
semanticscholar   +1 more source

Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the mouse anterior brainstem

eLife
Selector transcription factors (TFs) control choices of alternative cellular fates during development. The ventral rhombomere 1 of the embryonic mouse (Mus musculus) brainstem produces neuronal precursors that can differentiate into either inhibitory ...
Sami Kilpinen, Lassi Virtanen, Silvana Bodington Celma, Amos Bonsdorff, Heidi Heliölä, Kaia Achim, Juha Partanen   +6 more
doaj   +1 more source

A candidate projective neuron type of the cerebellar cortex: the synarmotic neuron

European Journal of Histochemistry
Previous studies on the granular layer of the cerebellar cortex have revealed a wide distribution of different subpopulations of less-known large neuron types, called “non-traditional large neurons”, which are distributed in three different zones of the
Paolo Flace, Diana Galletta, Antonella Bizzoca, Gianfranco Gennarini, Paolo Livrea   +4 more
doaj   +1 more source

Role for TGF-β superfamily signaling in telencephalic GABAergic neuron development

Journal of Neurodevelopmental Disorders, 2009
Signaling mechanisms mediated by the Transforming Growth Factor-β (TGF-β) superfamily regulate a variety of developmental processes. Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-β/activin/Nodal ...
M. Maira, Jason E. Long, Amie Y. Lee, J. Rubenstein, S. Stifani   +4 more
semanticscholar   +1 more source

Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington’s disease

Nature Communications, 2020
Huntington’s disease (HD) is caused by Huntingtin (Htt) gene mutation resulting in the loss of striatal GABAergic neurons and motor functional deficits. We report here an in vivo cell conversion technology to reprogram striatal astrocytes into GABAergic ...
Zheng Wu, Matthew Parry, Xiao-Yi Hou, Min-Hui Liu, Hui Wang, Rachel E. Cain, Zifei Pei, Yu-Chen Chen, Zi-Yuan Guo, Sambangi Abhijeet, Gong Chen   +10 more
semanticscholar   +1 more source

Non-Cell-Autonomous Regulation of GABAergic Neuron Development by Neurotrophins and the p75 Receptor

Journal of Neuroscience, 2007
Basal forebrain GABAergic and cholinergic circuits regulate the activity of cholinergic projections to the cortex and hippocampus. Because these projections influence cortical development and function, the development of basal forebrain excitatory and ...
P. Lin, Jeanine M. Hinterneder, Sarah Rollor, S. Birren   +3 more
semanticscholar   +1 more source

GABAergic interneurons in the neocortex: From cellular properties to circuits

Neuron, 2016
Cortical networks are composed of glutamatergic excitatory projection neurons and local GABAergic inhibitory interneurons which gate signal flow and sculpt network dynamics. Although they represent a minority of the total neocortical neuronal population,
R. Tremblay, Soohyun Lee, B. Rudy
semanticscholar   +1 more source

Mechanism research progress of acupuncture for ameliorating pain-related emotions through regulating GABAergic system

针刺研究
Pain-related emotions refer to the negative emotions such as depression and anxiety triggered by pain， which seriously impact patients’ physical and mental health as well as the quality of life.
LU Hong-yu, Wang Bao-jin, MA Cui, YAN Xing-ke   +3 more
doaj   +2 more sources