Results 71 to 80 of about 914,049 (192)

Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development. [PDF]

PLoS ONE, 2013
Central nervous system GABAergic and glycinergic synaptic activity switches from postsynaptic excitation to inhibition during the stage when motor neuron numbers are being reduced, and when synaptic connections are being established onto and by motor ...
Matthew J Fogarty, Karen L Smallcombe, Yuchio Yanagawa, Kunihiko Obata, Mark C Bellingham, Peter G Noakes   +5 more
doaj   +1 more source

Effects of sensory deprivation on glomerular interneurons in the mouse olfactory bulb: differences in mortality and phenotypic adjustment of dopaminergic neurons

Frontiers in Cellular Neuroscience, 2023
Neurogenesis persists in the mammalian subventricular zone after birth, producing various populations of olfactory bulb (OB) interneurons, including GABAergic and mixed dopaminergic/GABAergic (DA) neurons for the glomerular layer. While olfactory sensory
Alexandra Angelova, Marie-Catherine Tiveron, Mathieu D. Loizeau, Harold Cremer, Jean-Claude Platel   +4 more
doaj   +1 more source

Dopamine D2 Receptor Activity Modulates Akt Signaling and Alters GABAergic Neuron Development and Motor Behavior in Zebrafish Larvae

Journal of Neuroscience, 2011
An imbalance in dopamine-mediated neurotransmission is a hallmark physiological feature of neuropsychiatric disorders, such as schizophrenia. Recent evidence demonstrates that dopamine D2 receptors, which are the main target of antipsychotics, modulate ...
B. R. Souza, M. Romano-Silva, V. Tropepe
semanticscholar   +1 more source

Differential pH Dynamics in Synaptic Vesicles From Intact Glutamatergic and GABAergic Synapses

Frontiers in Synaptic Neuroscience, 2018
Synaptic transmission requires the presynaptic release of neurotransmitter from synaptic vesicles (SVs) onto the postsynaptic neuron. Vesicular neurotransmitter transporter proteins, which use a V-ATPase-generated proton gradient, play a crucial role in ...
Melissa A. Herman, Thorsten Trimbuch, Christian Rosenmund   +2 more
doaj   +1 more source

GABAergic Input From the Basal Forebrain Promotes the Survival of Adult-Born Neurons in the Mouse Olfactory Bulb

Frontiers in Neural Circuits, 2020
A unique feature of the olfactory system is the continuous generation and integration of new neurons throughout adulthood. Adult-born neuron survival and integration is dependent on activity and sensory experience, which is largely mediated by early ...
Elizabeth Hanson, Jessica Swanson, Benjamin R. Arenkiel, Benjamin R. Arenkiel, Benjamin R. Arenkiel, Benjamin R. Arenkiel   +5 more
doaj   +1 more source

Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice

Communications Biology, 2023
XBP1s is a key effector of the unfolded protein response. Neuron-specific overexpression of Xbp1s in the brain leads to impaired GABAergic signaling and recurrent spontaneous seizures in mice.
Zhuoran Wang, Qiang Li, Brad J. Kolls, Brian Mace, Shu Yu, Xuan Li, Wei Liu, Eduardo Chaparro, Yuntian Shen, Lihong Dang, Ángela del Águila, Joshua D. Bernstock, Kory R. Johnson, Junjie Yao, William C. Wetsel, Scott D. Moore, Dennis A. Turner, Wei Yang   +17 more
doaj   +1 more source

GABAergic synapses made by a retinal dopaminergic neuron [PDF]

Proceedings of the National Academy of Sciences, 2003
In the retina, dopaminergic amacrine (interplexiform) cells establish multiple synapses on the perikarya of AII amacrines, the neurons that distribute rod signals to on- and off-cone bipolars. We used triple-label immunocytochemistry and confocal microscopy to identify the receptors contained within the postsynaptic active zone of ...
CONTINI, MASSIMO, RAVIOLA E.
openaire   +3 more sources

Identification of rat ventral tegmental area GABAergic neurons. [PDF]

PLoS ONE, 2012
The canonical two neuron model of opioid reward posits that mu opioid receptor (MOR) activation produces reward by disinhibiting midbrain ventral tegmental area (VTA) dopamine neurons through inhibition of local GABAergic interneurons.
Elyssa B Margolis, Brian Toy, Patricia Himmels, Marisela Morales, Howard L Fields   +4 more
doaj   +1 more source

Functional Access to Neuron Subclasses in Rodent and Primate Forebrain

Cell Reports, 2019
Summary: Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive.
Preeti Mehta, Lauren Kreeger, Dennis C. Wylie, Jagruti J. Pattadkal, Tara Lusignan, Matthew J. Davis, Gergely F. Turi, Wen-Ke Li, Matthew P. Whitmire, Yuzhi Chen, Bridget L. Kajs, Eyal Seidemann, Nicholas J. Priebe, Attila Losonczy, Boris V. Zemelman   +14 more
doaj   +1 more source

The polymicrogyria-associated GPR56 promoter preferentially drives gene expression in developing GABAergic neurons in common marmosets

Scientific Reports, 2020
GPR56, a member of the adhesion G protein-coupled receptor family, is abundantly expressed in cells of the developing cerebral cortex, including neural progenitor cells and developing neurons.
Ayako Y. Murayama, Ken-ichiro Kuwako, Junko Okahara, Byoung-Il Bae, Misako Okuno, Hiromi Mashiko, Tomomi Shimogori, Christopher A. Walsh, Erika Sasaki, Hideyuki Okano   +9 more
doaj   +1 more source