Results 51 to 60 of about 914,049 (192)

Medial and dorsal lateral septum involving social disruption stress-primed escalation in acid-induced writhes

Frontiers in Molecular Neuroscience, 2023
IntroductionStress may cause prospective escalations in abdominal pain magnitude and accumbal TRPV1 expression, while central neural circuits mediating these stress effects remain unclear.MethodsUsing retrograde tracing methods, we first demonstrated the
Yi-Han Liao, Yi-Han Liao, Li-Han Sun, Yi-Chi Su, Wei-Jen Yao, Lung Yu, Lung Yu, Lung Yu   +7 more
doaj   +1 more source

Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control

Medical Review, 2022
Gamma-aminobutyric acid (GABAergic) neuron, as one of important cell types in synaptic transmission, has been widely involved in central nervous system (CNS) regulation of organismal physiologies including cognition, emotion, arousal and reward. However,
Jiang Hong
doaj   +1 more source

GABAergic neuron-specific loss of Ube3a causes Angelman syndrome-like EEG abnormalities and enhances seizure susceptibility

Neuron, 2016
SUMMARY Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical ...
Matthew C. Judson, Michael L. Wallace, Michael S. Sidorov, A. Burette, Bin Gu, Geeske M. van Woerden, I. F. King, Ji Eun Han, M. Zylka, Y. Elgersma, R. Weinberg, Benjamin D. Philpot   +11 more
semanticscholar   +1 more source

GABAergic neurons are susceptible to BAX-dependent apoptosis following isoflurane exposure in the neonatal period.

PLoS ONE, 2021
Exposure to volatile anesthetics during the neonatal period results in acute neuron death. Prior work suggests that apoptosis is the dominant mechanism mediating neuron death.
Andrew M Slupe, Laura Villasana, Kevin M Wright   +2 more
doaj   +1 more source

Anti-LINGO-1 antibody ameliorates cognitive impairment, promotes adult hippocampal neurogenesis, and increases the abundance of CB1R-rich CCK-GABAergic interneurons in AD mice

Neurobiology of Disease, 2021
In view of the negative regulatory effect of leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO-1) on neurons, an antibody against LINGO-1 (anti-LINGO-1 antibody) was herein administered to 10-month ...
Qi He, Lin Jiang, Yi Zhang, Hao Yang, Chun-Ni Zhou, Yu-Han Xie, Yan-Min Luo, Shan-Shan Zhang, Lin Zhu, Yi-Jing Guo, Yu-Hui Deng, Xin Liang, Qian Xiao, Lei Zhang, Jing Tang, Du-Juan Huang, Yu-Ning Zhou, Xiao-Yun Dou, Feng-Lei Chao, Yong Tang   +19 more
doaj   +1 more source

Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells

Aging and Disease, 2017
GABAergic neuronal cell grafting has promise for treating a multitude of neurological disorders including epilepsy, age-related memory dysfunction, Alzheimer’s disease and schizophrenia.
Qian-Fa Long, Q. Luo, Kai Wang, Adrian A. Bates, A. Shetty   +4 more
semanticscholar   +1 more source

Contribution of synchronized GABAergic neurons to dopaminergic neuron firing and bursting [PDF]

Journal of Neurophysiology, 2016
In the ventral tegmental area (VTA), interactions between dopamine (DA) and γ-aminobutyric acid (GABA) neurons are critical for regulating DA neuron activity and thus DA efflux. To provide a mechanistic explanation of how GABA neurons influence DA neuron firing, we developed a circuit model of the VTA.
Morozova E. O., Myroshnychenko M., Zakharov D., di Volo M., Gutkin B., Lapish C. C., Kuznetsov A.   +6 more
openaire   +3 more sources

A single GABAergic neuron mediates feedback of odor-evoked signals in the mushroom body of larval Drosophila

Front. Neural Circuits, 2014
Inhibition has a central role in defining the selectivity of the responses of higher order neurons to sensory stimuli. However, the circuit mechanisms of regulation of these responses by inhibitory neurons are still unclear.
L. Masuda-Nakagawa, Kei Ito, T. Awasaki, C. O'Kane   +3 more
semanticscholar   +1 more source

GABAergic neurons in the mammalian intestine.

Folia Pharmacologica Japonica, 1985
Most of the criteria for identification of a neurotransmitter were satisfied for gamma-aminobutyric acid (GABA) in the mammalian intestine. GABA and its synthesizing enzyme, glutamic acid decarboxylase, and the neurons which specifically accumulate GABA were demonstrated to localize in Auerbach's plexus of the intestine.
openaire   +3 more sources

The enigmatic function of chandelier cells

Frontiers in Neuroscience, 2010
Chandelier (or axo-axonic) cells are one of the most distinctive GABAergic interneurons in the brain. Their exquisite target specificity for the axon initial segment of pyramidal neurons, together with their GABAergic nature, long suggested the ...
Alan R Woodruff, Stewart A Anderson, Rafael eYuste   +2 more
doaj   +1 more source