Results 61 to 70 of about 914,049 (192)

Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain

Neuron, 2012
Neuropathic pain is a chronic debilitating disease characterized by mechanical allodynia and spontaneous pain. Because symptoms are often unresponsive to conventional methods of pain treatment, new therapeutic approaches are essential.
J. Bráz, R. Sharif-Naeini, D. Vogt, A. Kriegstein, A. Álvarez-Buylla, J. Rubenstein, A. Basbaum   +6 more
semanticscholar   +1 more source

Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex

Science, 2023
Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid–producing (GABAergic) neurons from subclasses to a high diversity of more granular types.
B. Lee, R. Dalley, Jeremy A. Miller, Thomas Chartrand, Jennie L. Close, Rusty Mann, A. Mukora, Lindsay Ng, L. Alfiler, Katherine S. Baker, Darren Bertagnolli, Krissy Brouner, Tamara Casper, É. Csajbók, Nicholas P. Donadio, Stan L. W. Driessens, Tom Egdorf, Rachel Enstrom, A. Galakhova, A. Gary, Emily C. Gelfand, Jeff Goldy, Kristen Hadley, Tim S. Heistek, Dijon Hill, W. Hou, Nelson J. Johansen, Nikolas L. Jorstad, Lisa Kim, Á. Kocsis, Lauren Kruse, Michael Kunst, Gabriela Leon, Brian Long, M. Mallory, Michelle Maxwell, M. McGraw, Delissa A. McMillen, Erica J. Melief, Gábor Molnár, M. Mortrud, Dakota Newman, J. Nyhus, X. Opitz-Araya, A. Ozsvár, Trangthanh Pham, A. Pom, L. Potekhina, R. Rajanbabu, Augustin Ruiz, S. Sunkin, Ildiko Szots, Naz Taskin, Bargavi Thyagarajan, Michael Tieu, Jessica Trinh, Sara Vargas, D. Vumbaco, Femke Waleboer, Sarah Walling-Bell, Natalie Weed, G. Williams, Julia Wilson, Shen-Qin Yao, Thomas Zhou, Pál Barzó, Trygve E Bakken, Charles Cobbs, Nick Dee, Richard G. Ellenbogen, Luke Esposito, Manuel Ferreira, N. Gouwens, Benjamin L. Grannan, R. Gwinn, J. Hauptman, R. Hodge, T. Jarsky, C. Keene, Andrew L. Ko, A. Korshoej, B. Levi, K. Meier, J. Ojemann, Anoop P. Patel, Jacob Ruzevick, D. Silbergeld, Kimberly A. Smith, J. C. Sørensen, Jack Waters, Hongkui Zeng, J. Berg, M. Capogna, N. Goriounova, B. Kalmbach, Christiaan P. J. de Kock, H. Mansvelder, S. Sorensen, G. Tamás, E. Lein, J. Ting   +100 more
semanticscholar   +1 more source

Integrins Have Cell-Type-Specific Roles in the Development of Motor Neuron Connectivity

Journal of Developmental Biology, 2019
Formation of the nervous system requires a complex series of events including proper extension and guidance of neuronal axons and dendrites. Here we investigate the requirement for integrins, a class of transmembrane cell adhesion receptors, in ...
Devyn Oliver, Emily Norman, Heather Bates, Rachel Avard, Monika Rettler, Claire Y. Bénard, Michael M. Francis, Michele L. Lemons   +7 more
doaj   +1 more source

Deletion of FGF9 in GABAergic neurons causes epilepsy

Cell Death and Disease, 2021
Fibroblast growth factor 9 (FGF9) has long been assumed to modulate multiple biological processes, yet very little is known about the impact of FGF9 on neurodevelopment.
Moran Guo, Can Cui, Xueqin Song, Lijing Jia, Duan Li, Xiuli Wang, Hui Dong, Yanqin Ma, Yaling Liu, Zhiqiang Cui, Le Yi, Zhongyao Li, Yue Bi, Yuanyuan Li, Yakun Liu, Weisong Duan, Chunyan Li   +16 more
doaj   +1 more source

GABAergic Neuron Specification in the Spinal Cord, the Cerebellum, and the Cochlear Nucleus

Journal of Neural Transplantation and Plasticity, 2012
In the nervous system, there are a wide variety of neuronal cell types that have morphologically, physiologically, and histochemically different characteristics.
Kei Hori, M. Hoshino
semanticscholar   +1 more source

A GABAergic and peptidergic sleep neuron as a locomotion stop neuron with compartmentalized Ca2+ dynamics

Nature Communications, 2019
The GABAergic and peptidergic neuron RIS mediates sleep in Caenorhabditis elegans. The authors demonstrated here that RIS also functions as a locomotion stop neuron.
Wagner Steuer Costa, Petrus Van der Auwera, Caspar Glock, Jana F. Liewald, Maximilian Bach, Christina Schüler, Sebastian Wabnig, Alexandra Oranth, Florentin Masurat, Henrik Bringmann, Liliane Schoofs, Ernst H. K. Stelzer, Sabine C. Fischer, Alexander Gottschalk   +13 more
doaj   +1 more source

Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine.

PLoS Computational Biology, 2021
Loss of function mutations of SCN1A, the gene coding for the voltage-gated sodium channel NaV1.1, cause different types of epilepsy, whereas gain of function mutations cause sporadic and familial hemiplegic migraine type 3 (FHM-3).
Louisiane Lemaire, Mathieu Desroches, Martin Krupa, Lara Pizzamiglio, Paolo Scalmani, Massimo Mantegazza   +5 more
doaj   +1 more source

Microglia-derived TNF-α inhibiting GABAergic neurons in the anterior lateral bed nucleus of the stria terminalis precipitates visceral hypersensitivity induced by colorectal distension in rats

Neurobiology of Stress, 2022
Irritable bowel syndrome (IBS) is a common and debilitating gastrointestinal disorder that is exacerbated by stress and characterized by abdominal pain.
Ning-Ning Ji, Qing-Xiang Meng, Ying Wang, Zi-Ming Zhou, Yu Song, Rong Hua, Yong-Mei Zhang   +6 more
doaj   +1 more source

Autism genes converge on asynchronous development of shared neuron classes

Nature, 2022
Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes spanning a wide range of biological functions1–6. The alterations in the human brain resulting from mutations in these genes remain unclear.
Bruna S. Paulsen, Silvia Velasco, Amanda J. Kedaigle, Martina Pigoni, Giorgia Quadrato, A. Deo, X. Adiconis, Ana Uzquiano, R. Sartore, S. Yang, Sean K. Simmons, Panagiotis Symvoulidis, Kwanho Kim, K. Tsafou, Archana Podury, Catherine Abbate, Ashley Tucewicz, Samantha N Smith, Alexandre Albanese, Lindy E. Barrett, N. Sanjana, Xi Shi, Kwanghun Chung, K. Lage, E. Boyden, A. Regev, J. Levin, P. Arlotta   +27 more
semanticscholar   +1 more source

Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats

Frontiers in Cellular Neuroscience, 2018
Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined the ...
Boldizsár Czéh, Boldizsár Czéh, Boldizsár Czéh, Irina Vardya, Zsófia Varga, Fabia Febbraro, Dávid Csabai, Lena-Sophie Martis, Kristoffer Højgaard, Kim Henningsen, Elena V. Bouzinova, Attila Miseta, Kimmo Jensen, Kimmo Jensen, Ove Wiborg, Ove Wiborg   +15 more
doaj   +1 more source