Results 51 to 60 of about 546,048 (293)

Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity

Cell Reports, 2017
Summary: The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output.
Sarah Melzer, Mariana Gil, David E. Koser, Magdalena Michael, Kee Wui Huang, Hannah Monyer   +5 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

eLife, 2019
Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy.
Ying Sun, Carlos Blanco-Centurion, Emmaline Bendell, Aurelio Vidal-Ortiz, Siwei Luo, Meng Liu   +5 more
doaj   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

A novel GABAergic population in the medial vestibular nucleus maintains wakefulness and gates rapid eye movement sleep

iScience
Summary: Body rocking can either induce sleep or arousal. That is, the vestibular sense influences sleep-wake states. Neuronal interactions between sleep-wake systems and vestibular systems, however, remain unclear. In this study, we found that GABAergic
Daiki Nakatsuka, Takeshi Kanda, Makito Sato, Yukiko Ishikawa, Yoan Cherasse, Masashi Yanagisawa   +5 more
doaj   +1 more source

Structural organization of long-range GABAergic projection system of the hippocampus

Frontiers in Neuroanatomy, 2009
GABA is a key mediator of neural activity in the mammalian central nervous system, and a diverse set of GABAergic neurons utilize GABA as transmitter. It has been widely accepted that GABAergic neurons typically serve as interneurons while glutamatergic ...
Shozo Jinno
doaj   +1 more source

Identification of a Group of GABAergic Neurons in the Dorsomedial Area of the Locus Coeruleus. [PDF]

PLoS ONE, 2016
The locus coeruleus (LC)-norepinephrine (NE) system in the brainstem plays a critical role in a variety of behaviors is an important target of pharmacological intervention to several neurological disorders.
Xin Jin, Shanshan Li, Brian Bondy, Weiwei Zhong, Max F Oginsky, Yang Wu, Christopher M Johnson, Shuang Zhang, Ningren Cui, Chun Jiang   +9 more
doaj   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source

Epigenetic regulation of prefrontal cortex GABAergic neurons in schizophrenia pathogenesis.

, 2008
Epigenetic regulation of prefrontal cortex GABAergic neurons in schizophrenia ...
William Bradley. Ruzicka (7975919)
core   +3 more sources

Dexmedetomidine Inhibition of GABA Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice

Brain and Behavior
Introduction Dexmedetomidine is a sedative anesthetic with a unique ability to produce an arousable state of sedation. However, the neural mechanisms underlying this arousable sedation remain incompletely understood.
Jin Rao, Gaolin Qiu, Jiansheng Wang, Yuanhai Li   +3 more
doaj   +1 more source