Results 41 to 50 of about 546,048 (293)

A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy

Cell Discovery, 2022
Physiological rapid eye movement (REM) sleep termination is vital for initiating non-REM (NREM) sleep or arousal, whereas the suppression of excessive REM sleep is promising in treating narcolepsy.
Ze-Ka Chen, Hui Dong, Cheng-Wei Liu, Wen-Ying Liu, Ya-Nan Zhao, Wei Xu, Xiao Sun, Yan-Yu Xiong, Yuan-Yuan Liu, Xiang-Shan Yuan, Bing Wang, Michael Lazarus, Yoan Chérasse, Ya-Dong Li, Fang Han, Wei-Min Qu, Feng-Fei Ding, Zhi-Li Huang   +17 more
doaj   +1 more source

Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus [PDF]

, 2015
The dorsal raphe nucleus (DRN) provides the major source of serotonin to the central nervous system (CNS) and modulates diverse neural functions including mood.
Lambert, Jeremy J., Swinny, Jerome D., Corteen, Nicole L., Rudolph, Uwe, Carter, Jessica A., Belelli, Delia   +5 more
core   +1 more source

Contribution of synchronized GABAergic neurons to dopaminergic neuron firing and bursting [PDF]

Journal of Neurophysiology, 2016
In the ventral tegmental area (VTA), interactions between dopamine (DA) and γ-aminobutyric acid (GABA) neurons are critical for regulating DA neuron activity and thus DA efflux. To provide a mechanistic explanation of how GABA neurons influence DA neuron firing, we developed a circuit model of the VTA. The model is based on feed-forward inhibition and
Morozova E. O., Myroshnychenko M., Zakharov D., di Volo M., Gutkin B., Lapish C. C., Kuznetsov A.   +6 more
openaire   +3 more sources

GABAergic neurons in the mammalian intestine.

Folia Pharmacologica Japonica, 1985
Most of the criteria for identification of a neurotransmitter were satisfied for gamma-aminobutyric acid (GABA) in the mammalian intestine. GABA and its synthesizing enzyme, glutamic acid decarboxylase, and the neurons which specifically accumulate GABA were demonstrated to localize in Auerbach's plexus of the intestine.
openaire   +3 more sources

Acidosis-Induced Dysfunction of Cortical GABAergic Neurons through Astrocyte-Related Excitotoxicity.

PLoS ONE, 2015
BackgroundAcidosis impairs cognitions and behaviors presumably by acidification-induced changes in neuronal metabolism. Cortical GABAergic neurons are vulnerable to pathological factors and their injury leads to brain dysfunction.
Li Huang, Shidi Zhao, Wei Lu, Sudong Guan, Yan Zhu, Jin-Hui Wang   +5 more
doaj   +1 more source

SAT1, a glutamine transporter, is preferentially expressed in GABAergic neurons

Frontiers in Neuroanatomy, 2010
Subsets of GABAergic neurons are able to maintain high frequency discharge patterns, which requires efficient replenishment of the releasable pool of GABA.
Tom Tallak Solbu, Tom Tallak Solbu, Mona Bjørkmo, Mona Bjørkmo, Paul Berghuis, Tibor Harkany, Tibor Harkany, Farrukh A Chaudhry, Farrukh A Chaudhry   +8 more
doaj   +1 more source

GABAergic inhibition controls neural gain in inferior colliculus neurons sensitive to interaural time differences [PDF]

, 2005
We investigated the role of GABAergic inhibition on the responses of inferior colliculus (IC) neurons sensitive to interaural time differences (ITDs) in anesthetized guinea pigs.
Ingham, NJ, Mcalpine, D
core  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Characterization of GABAergic neurons in the mouse lateral septum: a double fluorescence in situ hybridization and immunohistochemical study using tyramide signal amplification. [PDF]

PLoS ONE, 2013
Gamma-aminobutyric acid (GABA) neurotransmission in the lateral septum (LS) is implicated in modulating various behavioral processes, including emotional reactivity and maternal behavior. However, identifying the phenotype of GABAergic neurons in the CNS
Changjiu Zhao, Brian Eisinger, Stephen C Gammie   +2 more
doaj   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli, Karine Lacourse, Hélène Blais, Anne‐Sophie Deshaies‐Rugama, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Christophe Moderie, Boshra Khajehpiri, Catherine Duclos, Jean Marc Lina, Julie Carrier, Nadia Gosselin   +13 more
wiley   +1 more source