Results 231 to 240 of about 60,324 (289)

Optimization of gabapentin dosage in pediatric patients with renal impairment: a physiologically based pharmacokinetic modeling approach. [PDF]

Front Pharmacol
Qin X, Shen C, Li Z, Yang Y.
europepmc   +1 more source

Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss

Aging Cell, Volume 25, Issue 2, February 2026.
Senescent hippocampal astrocytes lose TSP secretion, impairing excitatory synaptogenesis via the α2δ‐1 pathway. Restoring TSP‐1 rescues synaptic formation, revealing the contribution of astrocyte senescence to age‐related hippocampal synaptic decline.
Stefano Ercoli, Lucía Casares‐Crespo, Elena Juárez‐Escoto, Helena Mira   +3 more
wiley   +1 more source

Beyond Oral Pain: A Unique Case of Burning Mouth Syndrome With Coexisting Vulvodynia and Cognitive Impairment in a Postmenopausal Woman. [PDF]

Clin Case Rep
Annam R, De Onaindia M, Partin C.
europepmc   +1 more source

Evaluation of the pollution pressures posed by groups of chemicals on British riverine invertebrate populations

Biological Reviews, Volume 101, Issue 1, Page 106-127, February 2026.
ABSTRACT Globally, rivers receive a diverse range of chemicals, including metals, pesticides, persistent organic pollutants, petrochemicals, human and veterinary pharmaceuticals and personal care products. However, the extent to which these different chemical groups affect riverine invertebrate communities is not well defined.
Imogen P. Poyntz‐Wright, Xavier A. Harrison, Charles R. Tyler   +2 more
wiley   +1 more source

CX3CR1-TLR4 Axis as a Shared Neuroimmune Target in COVID-19 and Epilepsy: Integrative Transcriptomics and Gabapentin Repositioning. [PDF]

Biomedicines
Pan N, Cao P, Chen B, Chen L, Liao X, Ning Y.   +5 more
europepmc   +1 more source

Novel Clinical Insights From a Swedish RFC1 Spectrum Disorder Cohort

European Journal of Neurology, Volume 33, Issue 2, February 2026.
In this study, we clinically characterized a Swedish cohort with biallelic RFC1 expansions by retrospectively enrolling 30 patients from a tertiary center and analyzing their clinical, genetic, and detailed phenotypic features. Our results suggest a Swedish founder effect in the Norrbotten region and indicate that RFC1‐spectrum disorder should be ...
Victor Alm, Linda Säll, Kristin Samuelsson, Rayomand Press, Snjolaug Arnardottir, Anna Lindstrand, Valter Niemelä, Lilia Terinte, Frida Nordin, Per Svenningsson, Daniel Nilsson, Luca Verrecchia, Martin Paucar   +12 more
wiley   +1 more source

Evaluation of the effectiveness and safety of ONO‐2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo‐controlled, double‐blind study in Japanese patients

Journal of Diabetes Investigation, Volume 17, Issue 2, Page 310-320, February 2026.
ABSTRACT Aims/Introduction Diabetic polyneuropathy (DPN) is common in patients with diabetes. Its symptoms include pain, numbness, and impaired neurosensory function. ONO‐2910 promotes Schwann cell differentiation and is being developed for DPN. Materials and Methods This Phase IIa randomized controlled trial evaluated the effectiveness and safety of ...
Yukiko Onishi, Takeshi Osonoi, Norio Takahashi, Toru Takiguchi, Eiichiro Morishima, Yoshimasa Aso, Kenji Sekiguchi, Hideki Kamiya, Jiro Nakamura   +8 more
wiley   +1 more source

Correlation between gabapentin and depression: A study from the NHANES and FAERS databases. [PDF]

Medicine (Baltimore)
Zhang H, Huang H, Ou H, Luo X, Zhang P, Zhao P.   +5 more
europepmc   +1 more source

Astrocyte Regulation of Spinal Circuit Function

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff, Min Jun Li, Axel Nimmerjahn   +2 more
wiley   +1 more source

Comparison of the Anxiolytic and Analgesic Effects of Gabapentin and Pregabalin in Cats: A Systematic Review. [PDF]

Animals (Basel)
Miranda-Cortés AE, Prado-Ochoa MG, Díaz-Torres R, Pérez-Sánchez AP, Del Río-García JC, Mota-Rojas D, Hernández-Avalos I.   +6 more
europepmc   +1 more source