Results 161 to 170 of about 3,167 (176)
GABARAPL1 is required for increased EGFR membrane expression during hypoxia
Radiotherapy and Oncology, 2015 Item does not contain fulltextBACKGROUND AND PURPOSE: The epidermal growth factor receptor (EGFR) is overexpressed, amplified or mutated in various human epithelial tumors and hypoxia is a common feature of solid tumors.
Tom Keulers +2 more
exaly +7 more sources
GABARAPL1 (GEC1) associates with autophagic vesicles [PDF]
Autophagy, 2010 International audienceGabarapl1 (gec1) was first described as an estrogen-regulated gene which shares a high sequence homology with the gabarap gene. We previously demonstrated that GABARAPL1, like GABARAP, interacts with the GABA(A) receptor and tubulin
Regis Delage-Mourroux +2 more
exaly +6 more sources
High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer [PDF]
British Journal of Cancer, 2010 International audienceBACKGROUND: This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma. METHODS: First, the relation between GABARAPL1 expression and
Regis Delage-Mourroux +2 more
exaly +5 more sources
Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein [PDF]
Biochimie, 2012 GABARAPL1 belongs to the small family of GABARAP proteins (including GABARAP, GABARAPL1 and GABARAPL2/GATE-16), one of the two subfamilies of the yeast Atg8 orthologue. GABARAPL1 is involved in the intracellular transport of receptors, via an interaction with tubulin and GABA(A) or kappa opioid receptors, and also participates in autophagy and cell ...
Sophie Croizier +2 more
exaly +3 more sources
GABARAPL1 (GEC1): Original or copycat? [PDF]
Autophagy, 2011 The GABARAPL1 (GABARAP-LIKE 1) gene was first described as an early estrogen-regulated gene that shares a high sequence homology with GABARAP and is thus a part of the GABARAP family. GABARAPL1, like GABARAP, interacts with the GABAA receptor and tubulin and promotes tubulin polymerization.
Regis Delage-Mourroux +2 more
exaly +3 more sources
The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models [PDF]
BMC Cancer, 2015 The GABARAP family members (GABARAP, GABARAPL1/GEC1 and GABARAPL2 /GATE-16) are involved in the intracellular transport of receptors and the autophagy pathway. We previously reported that GABARAPL1 expression was frequently downregulated in cancer cells while a high GABARAPL1 expression is a good prognosis marker for patients with lymph node-positive ...
Eric Hervouet +2 more
exaly +3 more sources
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Molecular Brain Research, 2003
GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons.
Christophe, Nemos +5 more
openaire +2 more sources
GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons.
Christophe, Nemos +5 more
openaire +2 more sources
Xenotransplantation, 2019
AbstractAfter hyperacute rejection in pig‐to‐primate xenotransplantation had been overcome by the introduction of α1,3‐galactosyltransferase gene‐knockout (GTKO) pigs, acute and chronic antibody‐mediated rejection became one of the major barriers to long‐term graft survival.
Lisha Mou +2 more
exaly +3 more sources
AbstractAfter hyperacute rejection in pig‐to‐primate xenotransplantation had been overcome by the introduction of α1,3‐galactosyltransferase gene‐knockout (GTKO) pigs, acute and chronic antibody‐mediated rejection became one of the major barriers to long‐term graft survival.
Lisha Mou +2 more
exaly +3 more sources
The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells [PDF]
Autophagy, 2014 GABARAPL1/GEC1 is an early estrogen-induced gene which encodes a protein highly conserved from C. elegans to humans. Overexpressed GABARAPL1 interacts with GABAA or kappa opioid receptors, associates with autophagic vesicles, and inhibits breast cancer cell proliferation.
Víctor Darley-Usmar +2 more
exaly +4 more sources
International Journal of Biological Macromolecules
Eosinophils play a featured role among inflammatory cells participating in the onset and development of asthma. Activated eosinophils release several cytotoxic granular proteins, such as major basic protein (MBP), posing a significant threat to airway epithelium.
Xiaojun Zha
exaly +3 more sources
Eosinophils play a featured role among inflammatory cells participating in the onset and development of asthma. Activated eosinophils release several cytotoxic granular proteins, such as major basic protein (MBP), posing a significant threat to airway epithelium.
Xiaojun Zha
exaly +3 more sources