Results 1 to 10 of about 11,313 (223)

Impact of Frequent Immune‐Mediated Adverse Events on Treatment Continuity and Outcomes During Durvalumab Plus Tremelimumab Therapy for Unresectable Hepatocellular Carcinoma

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Durvalumab plus tremelimumab (Dur/Tre) is the first‐line treatment for unresectable hepatocellular carcinoma (uHCC). Immune‐mediated adverse events (imAEs) are common; however, the impact of specific imAE types on treatment persistence and outcomes remains unclear.
Tomomitsu Matono, Toshifumi Tada, Atsushi Hiraoka, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Tanaka, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Hidekatsu Kuroda, Yutaka Yata, Hiroki Nishikawa, Michitaka Imai, Tomoko Aoki, Hironori Ochi, Hideyuki Tamai, Shohei Komatsu, Hideko Ohama, Fujimasa Tada, Shinichiro Nakamura, Kazuhiro Nouso, Asahiro Morishita, Norio Itokawa, Tomomi Okubo, Taeang Arai, Akemi Tsutsui, Takuya Nagano, Kazunari Tanaka, Takanori Matsuura, Yoshihide Ueda, Yuichi Koshiyama, Yuki Kanayama, Hidenao Noritake, Hirayuki Enomoto, Kosuke Matsui, Masaki Kaibori, Takumi Fukumoto, Yoichi Hiasa, Masatoshi Kudo, Takashi Kumada, on behalf of the RELPEC Group and HCC 48 Group   +53 more
wiley   +1 more source

Preclinical evaluation of Gd-DTPA and gadomelitol as contrast agents in DCE-MRI of cervical carcinoma interstitial fluid pressure

BMC Cancer, 2012
Background High interstitial fluid pressure (IFP) in the primary tumor is associated with poor disease-free survival in locally advanced cervical carcinoma. A noninvasive assay is needed to identify cervical cancer patients with highly elevated tumor IFP
Hompland Tord, Ellingsen Christine, Rofstad Einar K   +2 more
doaj   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Parameter Optimization for Quantitative Signal-Concentration Mapping Using Spoiled Gradient Echo MRI

Radiology Research and Practice, 2012
Rationale and Objectives. Accurate signal to tracer concentration maps are critical to quantitative MRI. The purpose of this study was to evaluate and optimize spoiled gradient echo (SPGR) MR sequences for the use of gadolinium (Gd-DTPA) as a kinetic ...
Gasser Hathout, Neema Jamshidi
doaj   +1 more source

Utility of Gd-EOB-DTPA-Enhanced MRI in Diagnosing Small Hepatocellular Carcinoma

Case Reports in Gastroenterology, 2009
We describe an 8-mm hepatocellular carcinoma (HCC) with hepatitis C virus-related cirrhosis in a 74-year-old woman. Ultrasound (US) revealed an 8-mm hyperechoic nodule in segment 6 of the liver.
Soo Ryang Kim, Susumu Imoto, Taisuke Nakajima, Kenji Ando, Keiji Mita, Katsumi Fukuda, Ryo Nishikawa, Yu-ichiro Koma, Toshiyuki Matsuoka, Masatoshi Kudo, Yoshitake Hayashi   +10 more
doaj   +1 more source

The blood–brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates—Evidence from in vivo neuroimaging studies

Neurobiology of Disease, 2009
It has been suggested, based on rodent studies, that levodopa (l-dopa) induced dyskinesia is associated with a disrupted blood–brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6 ...
Arnar Astradsson, Bruce G. Jenkins, Ji-Kyung Choi, Penelope J. Hallett, Michele A. Levesque, Jack S. McDowell, Anna-Liisa Brownell, Roger D. Spealman, Ole Isacson   +8 more
doaj   +1 more source

Novel MR imaging contrast agents for cancer detection

Journal of Research in Medical Sciences, 2009
<ul><li><strong>BACKGROUND</strong>: Novel potential MR imaging contrast agents Gd-tetra-carboranylmethoxyphenyl-porphyrin (Gd-TCP), Gd-hematoporphyrin (Gd-H), Gd-DTPA-9.2.27 against melanoma, Gd-DTPA-WM53 against leukemia and Gd ...
Daryoush Shahbazi-Gahrouei
doaj  

Comparison of the Ability of Gadobenate Dimeglumine and Gadolinium Ethoxybenzyl Dimeglumine to Display the major Features for Noninvasively Diagnosing Hepatocellular Carcinoma According to the LI-RADS 2018v

Technology in Cancer Research & Treatment
Objective To compare the ability of gadolinium ethoxybenzyl dimeglumine (Gd-EOB-DTPA) and gadobenate dimeglumine (Gd-BOPTA) to display the 3 major features recommended by the Liver Imaging Reporting and Data System (LI-RADS 2018v) for diagnosing ...
Wei-Wei Yao MD, Han-Wen Zhang MD, PhD, Yu-Pei M a, MD, Jia-Min Lee MD, Rui-ting Lee MD, Yu-li Wang MD, Xiao-lei Liu MD, Xin-Ping Shen MD, PhD, Biao Huang MD, PhD, Fan Lin MD, PhD   +9 more
doaj   +1 more source

Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis [PDF]

European Cells & Materials, 2007
Magnetic resonance imaging of articular cartilage has recently been recognized as a tool for the characterization of cartilage morphology, biochemistry and function.
G Blumenkrantz, S Majumdar
doaj  

Contrast Enhancement of the Brain by Folate-Conjugated Gadolinium–Diethylenetriaminepentaacetic Acid–Human Serum Albumin Nanoparticles by Magnetic Resonance Imaging

Molecular Imaging, 2012
Different from regular small molecule contrast agents, nanoparticle-based contrast agents have a longer circulation time and can be modified with ligands to confer tissue-specific contrasting properties.
Huedayi Korkusuz, Karsten Ulbrich, Verena Bihrer, Katerina Welzel, Valery Chernikov, Thomas Knobloch, Sabine Petersen, Frank Huebner, Hanns Ackermann, Svetlana Gelperina, Yuecel Korkusuz, Wolfgang Kromen, Renate Hammerstingl, Jörg Haupenthal, Jens Fiehler, Stefan Zeuzem, Jörg Kreuter, Thomas J. Vogl, Albrecht Piiper   +18 more
doaj   +1 more source