Results 131 to 140 of about 26,061 (186)
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On the determination of galactosamine-uronic acid
Analytical Biochemistry, 1966Abstract A procedure for measuring galactosamine-uronic acid was developed by modifying the Levvy-McAllan (10) colorimetric procedures for free hexosamines. The modification developed included a lower tetraborate concentration and a longer alkaline heating period. A shorter N -acetylation period is required than used by Roseman and Daffner (9). With
S T, Brownlee, R W, Wheat
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Biochimica et Biophysica Acta (BBA) - Enzymology, 1973
Abstract The activity of uridine diphosphoglucose (UDPG) dehydrogenase (UDPG: NAD+ oxidoreductase, EC 1.1.1.22) from rat liver is inhibited markedly in vitro by galactosamine 1-phosphate and UDPgalactosamine. The Ki value is calculated to be 6.2·10−3 M for galactosamine-1-phosphate. The type of inhibition is non-competitive.
Christian Bauer, Werner Reutter
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Abstract The activity of uridine diphosphoglucose (UDPG) dehydrogenase (UDPG: NAD+ oxidoreductase, EC 1.1.1.22) from rat liver is inhibited markedly in vitro by galactosamine 1-phosphate and UDPgalactosamine. The Ki value is calculated to be 6.2·10−3 M for galactosamine-1-phosphate. The type of inhibition is non-competitive.
Christian Bauer, Werner Reutter
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Toxicology and Applied Pharmacology, 1992
The effect of galactosamine on the resynthesis of glutathione in rat primary hepatocyte cultures was investigated. Cultured rat hepatocytes were treated with galactosamine (4 mM) 1.5 hr prior to concurrent with, or 1.5 hr after cell attachment; total cellular glutathione was then measured over time.
J M, McMillan, D J, Jollow
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The effect of galactosamine on the resynthesis of glutathione in rat primary hepatocyte cultures was investigated. Cultured rat hepatocytes were treated with galactosamine (4 mM) 1.5 hr prior to concurrent with, or 1.5 hr after cell attachment; total cellular glutathione was then measured over time.
J M, McMillan, D J, Jollow
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d-Galactosamine hepatotoxicity
Experimental and Molecular Pathology, 1978Abstract The role of free fatty acids (FFA) in the pathogenesis of fatty liver was investigated in female rats who received a single ip injection of d -galactosamine-HCl, (GalN), 750 mg/kg body weight. Groups of rats were either fasted for 14 hr prior to GalN injection and then fasted for the duration of the experiment or were fed ad libitum prior ...
Seymour M. Sabesin, James B. Ragland
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Analytical Biochemistry, 1963
Abstract A method is presented for the rapid differentiation, on a micro scale, of glucosamine, galactosamine, glucosamine uronic acid, and galactosamine uronic acid by paper electrophoresis of their deamination products in borate buffer. A new spray reagent for the specific detection of the 2-amino-2-deoxy sugars is also described; this is based on ...
A R, WILLIAMSON, S, ZAMENHOF
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Abstract A method is presented for the rapid differentiation, on a micro scale, of glucosamine, galactosamine, glucosamine uronic acid, and galactosamine uronic acid by paper electrophoresis of their deamination products in borate buffer. A new spray reagent for the specific detection of the 2-amino-2-deoxy sugars is also described; this is based on ...
A R, WILLIAMSON, S, ZAMENHOF
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Syntheses of α-d-galactosamine neoglycolipids
Carbohydrate Research, 2006Several N-acetyl-alpha-d-galactosamine neoglycolipids, as well as hydrophobized T and T(N) antigen analogues, were prepared for embedment onto liposomes. Three different lipidic structures were used for the anchoring, that is cholesterol, 1,3-bis(undecyloxy)propan-2-ol and 1,3-bis(3,7,11,15-tetramethylhexadecyloxy)propan-2-ol.
Nicolas, Laurent +2 more
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GALACTOSAMINE PREVENTS ETHINYLESTRADIOL-INDUCED CHOLESTASIS
Drug Metabolism and Disposition, 2006Ethinylestradiol (EE) induces intrahepatic cholestasis in experimental animals being its derivative, ethinylestradiol 17beta-glucuronide, a presumed mediator of this effect. To test whether glucuronidation is a relevant step in the pathogenesis of cholestasis induced by EE (5 mg/kg b.wt. s.c.
Fernando A, Crocenzi +6 more
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Determination of glucosamine and galactosamine by gas chromatography
Journal of Chromatography A, 1965Abstract A gas chromatographic method for simultaneous analysis and quantitative determination of glucosamine and galactosamine is described. Hexosamines were isolated from mucopolysaccharide hydrolyzates with Dowex-50 and converted to trimethylsilyl derivatives with trimethylchlorosilane and hexamethyldisilazane in pyridine solution at room ...
J, Kärkkäinen, A, Lehtonen, T, Nikkari
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Experimental hepatitis induced by d-galactosamine
Experimental and Molecular Pathology, 1968Abstract Repeated intraperitoneal injections of d -galactosamine produce within 24–48 hours in rat livers alterations that closely resemble human viral hepatitis. Histologic changes include necroses and inflammatory infiltration of periportal areas, mitoses and cell proliferation, the appearance of Councilman bodies, and an increased number of ...
D, Keppler +3 more
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Cystamine modulation of galactosamine-induced hepatotoxicity
Toxicology and Applied Pharmacology, 1984The ability of cystamine treatment to protect against galactosamine-induced hepatic necrosis was investigated. Reduced hepatotoxicity was observed following galactosamine hydrochloride (400 mg/kg, ip) in male Sprague-Dawley rats that received cystamine dihydrochloride (300 mg/kg, po) 30 min prior to or 2, 4, 6, 8, or 12 hr after galactosamine.
J R, MacDonald +2 more
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